Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Sheldon E. Ratnofsky"'
Autor:
David J. Calderwood, Wendy Waegell, Michelle Hart, Gavin C. Hirst, Annette Schwartz, Sheldon E. Ratnofsky, Brian Bettencourt, Robert F. Stachlewitz, Tegest Kebede
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 315:36-41
Lck, one of eight members of the Src family of tyrosine kinases, is activated after T cell stimulation and is required for T-cell proliferation and interleukin (IL)-2 production. Inhibition of Lck has been a target to prevent lymphocyte activation an
Autor:
Brad McRae, David W. Borhani, Biqin Li, Kurt Ritter, Gavin C. Hirst, David J. Calderwood, Wendy Waegell, Sheldon E. Ratnofsky, Michael Friedman, A.K.W. Leung
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:2613-2616
We have identified the pyrazolo[3,4-d]pyrimidine A-420983 (compound 7) as a potent inhibitor of lck. A-420983 exhibits oral efficacy in animal models of delayed-type hypersensitivity and organ transplant rejection.
Autor:
David J. Calderwood, Sheldon E. Ratnofsky, David N. Johnston, Rainer Munschauer, Joanne Kamens, Paul Rafferty, Richard W. Dixon, Arnold Lee D
Publikováno v:
ChemInform. 31
Pyrrolo[2,3-d]pyrimidines containing a 5-(4-phenoxyphenyl) substituent are potent and selective inhibitors of Ick in vitro; some compounds are selective for lck over src. Data are shown for two compounds demonstrating that they are potent and selecti
Autor:
Richard W. Dixon, Arnold Lee D, David N. Johnston, Rainer Munschauer, Sheldon E. Ratnofsky, David J. Calderwood, Paul Rafferty, Joanne Kamens
Publikováno v:
Bioorganicmedicinal chemistry letters. 10(19)
Pyrrolo[2,3-d]pyrimidines containing a 5-(4-phenoxyphenyl) substituent are potent and selective inhibitors of Ick in vitro; some compounds are selective for lck over src. Data are shown for two compounds demonstrating that they are potent and selecti