Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Sheldon Crane"'
Autor:
Jose Iglesias, Julien Lamontagne, Heidi Erb, Sari Gezzar, Shangang Zhao, Erik Joly, Vouy Linh Truong, Kathryn Skorey, Sheldon Crane, S.R.Murthy Madiraju, Marc Prentki
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 1, Pp 131-141 (2016)
Lipids are used as cellular building blocks and condensed energy stores and also act as signaling molecules. The glycerolipid/ fatty acid cycle, encompassing lipolysis and lipogenesis, generates many lipid signals. Reliable procedures are not availab
Externí odkaz:
https://doaj.org/article/aaa0c395233140d88d37074de991673c
Autor:
Sébastien Gagné, Sheldon Crane, Zheng Huang, Chun Sing Li, Kevin P. Bateman, Jean-François Lévesque
Publikováno v:
Journal of Lipid Research, Vol 48, Iss 1, Pp 252-259 (2007)
Imbalanced fatty acid metabolism contributes significantly to the increased incidence of metabolic disorders. Isotope-labeled fatty acids (2H, 13C) provide efficient means to trace fatty acid metabolism in vivo. This study reports a new and rapid met
Externí odkaz:
https://doaj.org/article/e82e6e471ebd4ca2a1a328ba3773d65d
Autor:
Shangang Zhao, Heidi Erb, Sari Gezzar, Kathryn Skorey, Jose Antonio Iglesias, Erik Joly, Julien Lamontagne, S.R. Murthy Madiraju, Vouy Linh Truong, Marc Prentki, Sheldon Crane
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 1, Pp 131-141 (2016)
Lipids are used as cellular building blocks and condensed energy stores and also act as signaling molecules. The glycerolipid/ fatty acid cycle, encompassing lipolysis and lipogenesis, generates many lipid signals. Reliable procedures are not availab
Autor:
Li Hao, Carolyn Bahnck-Teets, Catherine M. Wiscount, Daniel J. McKay, Carmela Molinaro, Ronald K. Chang, S S Carroll, Sivalenka Vijayasaradhi, Philippe G. Nantermet, Sanjay Kumar Singh, Christopher J. Bungard, Dubost David C, David Jonathan Bennett, Thomas J. Greshock, Hua-Poo Su, Rosa I. Sanchez, Vouy Linh Truong, Xu Min, John F. Fay, Jeanine E. Ballard, John A. McCauley, Christian Beaulieu, M. Katharine Holloway, Joseph P. Vacca, Michael W. Miller, Tummanapalli Satyanarayana, Sheldon Crane, William D. Shipe, Jesse J. Manikowski, Peter D. Williams, Christian Nadeau, Jennifer J. Gesell, Tracy L. Diamond, Peter J. Felock, Oscar Miguel Moradei
A novel HIV protease inhibitor was designed using a morpholine core as the aspartate binding group. Analysis of the crystal structure of the initial lead bound to HIV protease enabled optimization of enzyme potency and antiviral activity. This afford
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82f685aed82b9b428b5b9e7330d8f427
https://europepmc.org/articles/PMC4948015/
https://europepmc.org/articles/PMC4948015/
Autor:
Zheng Huang, Jocelyne Guay, Lei Zhang, David A. Powell, Joel Robichaud, Elise Isabel, Jean-Philippe Leclerc, Cameron Black, Serge Leger, Renata Oballa, Sébastien Guiral, Sheldon Crane, Chun Sing Li, Yeeman K. Ramtohul
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:5692-5696
Optimization of a lead thiazole amide MF-152 led to the identification of potent bicyclic heteroaryl SCD1 inhibitors with good mouse pharmacokinetic profiles. In a view to target the liver for efficacy and to avoid SCD1 inhibition in the skin and eye
Autor:
Robert Gordon, Lijing Xu, Michel Therien, W. Cameron Black, Martin Henault, Yaël Mamane, Chi-Chung Chan, Vouy Linh Truong, Michel Belley, Huda Hyjazie, Daniel Guay, Geoffrey K. Tranmer, Jeancarlo DeLuca, Zhaoyin Wang, Stacia Kargman, Christian Beaulieu, Martine Hamel, Sheldon Crane, Joseph A. Mancini, Lianhai Li, Nicolas Morin, Yves Gareau
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:2832-2835
A weak antagonist of the pyrimidinergic receptor P2Y(14) containing a dihydropyridopyrimidine core was identified through high-throughput screening. Subsequent optimization led to potent, non-UTP competitive antagonists and represent the first report
Autor:
Sheldon Crane, Lei Zhang, Jocelyne Guay, Sébastien Guiral, Chun Sing Li, Cameron Black, Lijing Xu, Yeeman K. Ramtohul, Renata Oballa, Zheng Huang, Chi-Chung Chan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:1593-1597
Elevated stearoyl-CoA desaturase (SCD) activity has been linked to a number of metabolic disorders including obesity and type II diabetes. Compound 3j, a potent SCD inhibitor (human HepG2 IC50 = 1 nM) was identified from the optimization of a lead th
Autor:
Christopher I. Bayly, Jean-François Truchon, Carl Berthelette, Renata Oballa, Stephen Day, Sheldon Crane, Nathalie Chauret
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:998-1002
Nitrile-based inhibitors of cathepsin K have been known for some time and mechanism-of-action studies have demonstrated that cysteinyl proteases interact with nitriles in a reversible fashion. Three main classes of nitrile-containing inhibitors have
Autor:
Jean-François Lévesque, Zheng Huang, Sheldon Crane, Chun Sing Li, Sébastien Gagné, Kevin P. Bateman
Publikováno v:
Journal of Lipid Research, Vol 48, Iss 1, Pp 252-259 (2007)
Imbalanced fatty acid metabolism contributes significantly to the increased incidence of metabolic disorders. Isotope-labeled fatty acids (2H, 13C) provide efficient means to trace fatty acid metabolism in vivo. This study reports a new and rapid met
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 49:1273-1285
Synthetic routes adaptable to the preparation of a variety of d7-labeled monounsaturated and saturated fatty acids are reported. Using these reaction sequences, d7-oleic [18:1 (9c)], d7-elaidic [18:1 (9t)], and d7-stearic acid (18:0) were prepared fo