Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Sheldon Cao"'
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Akademický článek
Antitumor activity of a 5T4 targeting antibody drug conjugate with a novel payload derived from MMAF via C‐Lock linker
Autor: Baoying Shi, Min Wu, Zhaohui Li, Zhangming Xie, Xiaoyue Wei, Jiansheng Fan, Yingchun Xu, Ding Ding, Sajid Hamid Akash, Shuqing Chen, Sheldon Cao
Publikováno v: Cancer Medicine, Vol 8, Iss 4, Pp 1793-1805 (2019)
Abstract Antibody‐drug conjugates (ADCs) belong to a promising class of biopharmaceuticals in which target‐killing of tumor cells was achieved by marrying the potency of the cytotoxic payload with the tumor specificity of the antibody. Here we de
Externí odkaz: https://doaj.org/article/9c87d86761794397804600c81c17f716
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Development of a bridging ELISA for detection of antibodies against ZV0203 in cynomolgus monkey serum
Autor: Tingting, Liu, Yongliang, Tong, Jinli, Gao, Wenjing, Fang, Junliang, Wu, Xionghua, Peng, Xiaotian, Fan, Xiaoqiang, Chen, Jianhua, Sun, Sheldon, Cao, Zhaohui, Li, Likun, Gong, Qiuping, Qin, Dianwen, Ju
Publikováno v: Journal of Pharmacological and Toxicological Methods. 119:107210
Immunogenicity has been a major concern in the safety evaluation of therapeutic proteins. The assessment of the unwanted immunogenicity of the therapeutic proteins performed in animals prior to clinical trials has been a regulatory requirement. In pr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62a19eb431faeb3e39acee3af8a9934c
https://doi.org/10.1016/j.vascn.2022.107210
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7
Antitumor activity of a 5T4 targeting antibody drug conjugate with a novel payload derived from MMAF via C‐Lock linker
Autor: Xiaoyue Wei, Baoying Shi, Shuqing Chen, Sajid Hamid Akash, Zhaohui Li, Min Wu, Yingchun Xu, Sheldon Cao, Ding Ding, Zhangming Xie, Jiansheng Fan
Publikováno v: Cancer Medicine, Vol 8, Iss 4, Pp 1793-1805 (2019)
Cancer Medicine
Antibody‐drug conjugates (ADCs) belong to a promising class of biopharmaceuticals in which target‐killing of tumor cells was achieved by marrying the potency of the cytotoxic payload with the tumor specificity of the antibody. Here we developed a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb456271d170d09223b92128534796f8
https://doaj.org/article/9c87d86761794397804600c81c17f716
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8
Abstract 1214: Development of anti-5T4 antibody-drug conjugates, ZV05-ADCs for targeted cancer therapy in different type of cancers
Autor: Tong Zhu, Sheldon Cao, Hedi Fang, Jie Fang, Gang Chen, Qian Zhang, Hong Zhang, Liqin Wu, Zhangming Xie, Zhaohui Li, David Miao
Publikováno v: Cancer Research. 76:1214-1214
5T4 is an N-glycosylated transmembrane 72 kDa glycoprotein expressed in a number of carcinomas, and has been explored as a target for cancer therapy in different type of cancers, including NSCLC, RCC, colorectal, ovarian, pancreatic and gastric cance
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f2a7352cf4d23aeab2f37b7f7c59a7a7
https://doi.org/10.1158/1538-7445.am2016-1214
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Abstract 651: Superior anti-tumor activity compared to T-DM1 in preclinical studies of targeted therapies for her2-positive cancers by a novel her2-ADC ZV0201
Autor: Tong Zhu, Zhaohui Li, David Miao, Sheldon Cao, Hong Zhang, Gang Chen
Publikováno v: Cancer Research. 75:651-651
ZV0201 is a her2-targeting ADC based on newly developed K-Lock technology at Concortis. Anti-her2 Antibody ZV02 was conjugated with highly cytotoxic auristatin analogue through a non-cleavable linker to form ZV0201,which mainly consists of DAR2 speci
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a79bf5bf433ad95c081cc03fced63c1c
https://doi.org/10.1158/1538-7445.am2015-651
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