Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Shelby Winans"'
Autor:
Shelby Winans, Hyun Jae Yu, Kenia de los Santos, Gary Z. Wang, Vineet N. KewalRamani, Stephen P. Goff
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
HIV-1 integration sites are biased towards actively transcribed genes, likely mediated by binding of the viral integrase (IN) protein to host factors. Here, Winans et al. show that the K258R point mutation in IN eredirects viral DNA integration to th
Externí odkaz:
https://doaj.org/article/98197885cbc4460eb0cf719caab1e000
Autor:
Shelby Winans, Stephen P Goff
Publikováno v:
PLoS Pathogens, Vol 16, Iss 12, p e1009147 (2020)
The central function of the retroviral integrase protein (IN) is to catalyze the integration of viral DNA into the host genome to form the provirus. The IN protein has also been reported to play a role in a number of other processes throughout the re
Externí odkaz:
https://doaj.org/article/683eff356c794c6d9be273fd5452deb0
Publikováno v:
PLoS Pathogens, Vol 13, Iss 11, p e1006708 (2017)
Avian leukosis virus (ALV) is a simple retrovirus that causes a wide range of tumors in chickens, the most common of which are B-cell lymphomas. The viral genome integrates into the host genome and uses its strong promoter and enhancer sequences to a
Externí odkaz:
https://doaj.org/article/6f00ed9fe6b04c10a1b19c02a6aa4b4d
Autor:
Shelby, Winans, Hyun Jae, Yu, Kenia, de Los Santos, Gary Z, Wang, Vineet N, KewalRamani, Stephen P, Goff
Publikováno v:
Nature communications. 13(1)
Retroviruses utilize the viral integrase (IN) protein to integrate a DNA copy of their genome into host chromosomal DNA. HIV-1 integration sites are highly biased towards actively transcribed genes, likely mediated by binding of the IN protein to spe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a7d8fc283d8b517acb5ebfb93694eb5f
https://pubmed.ncbi.nlm.nih.gov/35304442
https://pubmed.ncbi.nlm.nih.gov/35304442
Autor:
Shelby Winans, Stephen P. Goff
Retroviruses utilize the viral integrase (IN) protein to integrate a DNA copy of their genome into the host chromosomal DNA. HIV-1 integration sites are highly biased towards actively transcribed genes, likely mediated by binding of the IN protein to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::703be86eaa3070dbabab568f096e8b62
https://doi.org/10.1101/2021.01.12.426369
https://doi.org/10.1101/2021.01.12.426369
Autor:
Jun Yao, Shelby Winans, Hengyi Xu, Douglas C. Wu, Elizabeth A. Ferrick-Kiddie, Manuel Ares, Alan M. Lambowitz
We used thermostable group II intron reverse transcriptase sequencing (TGIRT-seq), which gives full-length end-to-end sequence reads of structured RNAs, to identify > 8,500 short full-length excised linear intron (FLEXI) RNAs originating from > 3,500
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26d0d2e5c1c6033195a5dcaac4c337a5
https://doi.org/10.1101/2020.09.07.285114
https://doi.org/10.1101/2020.09.07.285114
Autor:
Stephen P. Goff, Shelby Winans
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 16, Iss 12, p e1009147 (2020)
PLoS Pathogens, Vol 16, Iss 12, p e1009147 (2020)
The central function of the retroviral integrase protein (IN) is to catalyze the integration of viral DNA into the host genome to form the provirus. The IN protein has also been reported to play a role in a number of other processes throughout the re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::635a0ddba829ccce9568d75d0acaf88b
https://pubmed.ncbi.nlm.nih.gov/33351861
https://pubmed.ncbi.nlm.nih.gov/33351861
Publikováno v:
Oncotarget
// Shelby Winans 1 , Alyssa Flynn 1 , Sanandan Malhotra 1 , Vidya Balagopal 1 and Karen L. Beemon 1 1 Department of Biology, Johns Hopkins University, Baltimore, MD 21218, USA Correspondence to: Karen L. Beemon, email: KLB@jhu.edu Keywords: CTD small
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81555746adbab5f86ebd9273c582f289
https://doi.org/10.18632/oncotarget.19328
https://doi.org/10.18632/oncotarget.19328
Autor:
Shelby Winans, Karen L. Beemon, Jiri Nehyba, Thomas H. O'Hare, James Justice, Sanandan Malhotra
Publikováno v:
Journal of Virology. 90:9509-9517
Avian leukosis virus (ALV) induces tumors by integrating its proviral DNA into the chicken genome and altering the expression of nearby genes via strong promoter and enhancer elements. Viral integration sites that contribute to oncogenesis are select
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::427dd796c70ad1393f7e00d2ca8b36fb
https://doi.org/10.1128/jvi.01127-16
https://doi.org/10.1128/jvi.01127-16
Autor:
Karen L. Beemon, Shelby Winans
Publikováno v:
Cell Host & Microbe. 26:154-155
In this issue of Cell Host & Microbe, Courtney et al. (2019a) find that HIV-1 genomic RNA has much more m5C than cellular mRNA. Deleting the m5C “writer” NSUN2 decreases HIV-1 m5C levels, promotes translation of the HIV-1 5′ gag gene, and alter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3e7c74d6add1719f795f0509d85f594
https://doi.org/10.1016/j.chom.2019.07.019
https://doi.org/10.1016/j.chom.2019.07.019