Výsledky vyhledávání - "Shelby R. Konfrst"

Harnessing the Plasma Proteome to Mirror Current and Predict Future Cardiac Remodeling After Myocardial Infarction

Autor: Upendra Chalise, Mediha Becirovic-Agic, Jocelyn R. Rodriguez-Paar, Shelby R. Konfrst, Sharon D. B. de Morais, Catherine S. Johnson, Elizabeth R. Flynn, Michael E. Hall, Daniel R. Anderson, Leah M. Cook, Kristine Y. DeLeon-Pennell, Merry L. Lindsey

Publikováno v: Journal of Cardiovascular Translational Research. 16:3-16

To identify plasma proteins that mirror current and predict future remodeling after myocardial infarction (MI), we retrospectively interrogated plasma proteomes of day (D)0 control (n = 16) and D3 MI (n = 15) from C57BL/6 J mice (20 ± 1 months). A t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::39d1dd99b462d076aae68948edfab42b
https://doi.org/10.1007/s12265-022-10326-w

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Macrophages secrete murinoglobulin-1 and galectin-3 to regulate neutrophil degranulation after myocardial infarction

Autor: Upendra Chalise, Michael J. Daseke, William J. Kalusche, Shelby R. Konfrst, Jocelyn R. Rodriguez-Paar, Elizabeth R. Flynn, Leah M. Cook, Mediha Becirovic-Agic, Merry L. Lindsey

Publikováno v: Molecular Omics. 18:186-195

Inflammation presides early after myocardial infarction (MI) as a key event in cardiac wound healing. Ischemic cardiomyocytes secrete inflammatory cues to stimulate infiltration of leukocytes, predominantly macrophages and neutrophils. Infiltrating n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::950626d686c27a28bb2ef14d260cf2f0
https://doi.org/10.1039/d1mo00519g

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Exogenous IL-4 shuts off pro-inflammation in neutrophils while stimulating anti-inflammation in macrophages to induce neutrophil phagocytosis following myocardial infarction

Autor: Upendra Chalise, Michael R. Garrett, Yonggang Ma, Kristine Y. DeLeon-Pennell, Merry L. Lindsey, Mavis Akosua Asantewaa Tenkorang-Impraim, Michael J. Daseke, Shelby R. Konfrst

Publikováno v: Journal of molecular and cellular cardiology

Introduction: Macrophages and neutrophils are primary leukocytes involved in the inflammatory response to myocardial infarction (MI). While interleukin (IL)-4 is an in vitro anti-inflammatory stimulus, the MI myocardium does not express a considerabl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e4d5baf726817ed3888cd1142986754
http://europepmc.org/articles/PMC7483959

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MMP-12 polarizes neutrophil signalome towards an apoptotic signature

Autor: Upendra Chalise, Mediha Becirovic-Agic, Shelby R. Konfrst, Jocelyn R. Rodriguez-Paar, Leah M. Cook, Merry L. Lindsey

Publikováno v: J Proteomics

While macrophages are well-known to polarize across the inflammatory spectrum, neutrophils have only recently been found to activate in a similar fashion in response to pro- or anti-inflammatory stimuli. Matrix metalloproteinase (MMP)-12 mediates neu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44d84f713ff814f828aee8d4761ea292
https://pubmed.ncbi.nlm.nih.gov/35661763

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Faster skin wound healing predicts survival after myocardial infarction

Autor: Mediha Becirovic-Agic, Upendra Chalise, Mira Jung, Jocelyn R. Rodriguez-Paar, Shelby R. Konfrst, Elizabeth R. Flynn, Jeffrey D. Salomon, Michael E. Hall, Merry L. Lindsey

Publikováno v: American journal of physiology. Heart and circulatory physiology. 322(4)

Both skin wound healing and the cardiac response to myocardial infarction (MI) progress through similar pathways involving inflammation, resolution, tissue repair, and scar formation. Due to the similarities, we hypothesized that the healing response

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2161f1115d55425c3b536c9e393c8ae
https://pubmed.ncbi.nlm.nih.gov/35089808

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S100A9 is a functional effector of infarct wall thinning after myocardial infarction

Autor: Upendra Chalise, Mediha Becirovic-Agic, Michael J. Daseke, Shelby R. Konfrst, Jocelyn R. Rodriguez-Paar, Dan Feng, Jeffrey D. Salomon, Daniel R. Anderson, Leah M. Cook, Merry L. Lindsey

Publikováno v: American journal of physiology. Heart and circulatory physiology. 322(2)

Neutrophils infiltrate into the left ventricle (LV) early after myocardial infarction (MI) and launch a proinflammatory response. Along with neutrophil infiltration, LV wall thinning due to cardiomyocyte necrosis also peaks at

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae5ee9d8d10420d1dc546a92a2e9a2b5
https://pubmed.ncbi.nlm.nih.gov/34890276

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Understanding the mechanisms that determine extracellular matrix remodeling in the infarcted myocardium

Autor: Shelby R. Konfrst, Mavis A.A. Tenkorang, Merry L. Lindsey, Upendra Chalise, Michael J. Daseke

Publikováno v: Biochemical Society Transactions. 47:1679-1687

Myocardial Infarction (MI) initiates a series of wound healing events that begins with up-regulation of an inflammatory response and culminates in scar formation. The extracellular matrix (ECM) is intricately involved in all stages from initial break

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f29a68500f64a5e11db1a9dfcb5cbdd7
https://doi.org/10.1042/bst20190113

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Infarct in the Heart: What’s MMP-9 Got to Do with It?

Autor: Mediha Becirovic-Agic, Michael J. Daseke, Jeffrey Salomon, Upendra Chalise, Paras Kumar Mishra, Shelby R. Konfrst, Merry L. Lindsey

Publikováno v: Biomolecules
Biomolecules, Vol 11, Iss 491, p 491 (2021)

Over the past three decades, numerous studies have shown a strong connection between matrix metalloproteinase 9 (MMP-9) levels and myocardial infarction (MI) mortality and left ventricle remodeling and dysfunction. Despite this fact, clinical trials

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de6260cb2c354aaaf58c652e8262a090
http://europepmc.org/articles/PMC8064345

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Cardiac fibroblast activation during myocardial infarction wound healing: Fibroblast polarization after MI

Autor: Michael J, Daseke, Mavis A A, Tenkorang, Upendra, Chalise, Shelby R, Konfrst, Merry L, Lindsey

Publikováno v: Matrix Biol

Cardiac wound healing after myocardial infarction (MI) evolves from pro-inflammatory to anti-inflammatory to reparative responses, and the cardiac fibroblast is a central player during the entire transition. The fibroblast mirrors changes seen in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9bdbf4081c615d9b40783bd1e1c16030
https://pubmed.ncbi.nlm.nih.gov/32446909

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