Zobrazeno 1 - 10
of 149
pro vyhledávání: '"Shelagh Ferguson-Miller"'
Publikováno v:
Journal of Bioenergetics and Biomembranes
The ancient membrane protein TSPO is phylogenetically widespread from archaea and bacteria to insects, vertebrates, plants, and fungi. TSPO’s primary amino acid sequence is only modestly conserved between diverse species, although its five transmem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bec1e64e695d572267a179c32ddf84a
http://europepmc.org/articles/PMC8243069
http://europepmc.org/articles/PMC8243069
Autor:
Shinya Yoshikawa, Keshav K. Singh, Rabia Ramzan, Shelagh Ferguson-Miller, Icksoo Lee, Lawrence I. Grossman, Maik Hüttemann, Sebastian Vogt
Publikováno v:
Mitochondrion. 60
In memoriam of Bernhard Kadenbach: Although the main focus of his research was the structure, function, and regulation of mitochondrial cytochrome c oxidase (CytOx), he earlier studied the mitochondrial phosphate carrier and found an essential role o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcc3a1a5c276e7618566fda2170039d1
https://pubmed.ncbi.nlm.nih.gov/34481964
https://pubmed.ncbi.nlm.nih.gov/34481964
Autor:
Jian Liu, Brandon T. Ruotolo, Sarah M Fantin, Shuai Niu, Sugyan M. Dixit, Shelagh Ferguson-Miller, Kristine F Parson, Daniel A. Polasky
Publikováno v:
Analytical Chemistry. 91:15469-15476
Membrane proteins represent most current therapeutic targets, yet remain understudied due to their insolubility in aqueous solvents and generally low yields during purification and expression. Ion mobility-mass spectrometry and collision induced unfo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76b92d62bbc0f808ca3823fb163b4c7f
https://doi.org/10.1021/acs.analchem.9b03208
https://doi.org/10.1021/acs.analchem.9b03208
Publikováno v:
Biophys J
The translocator protein (TSPO), previously known as the peripheral benzodiazepine receptor, is of longstanding medical interest as both a biomarker for neuroinjury and a potential drug target for neuroinflammation and other disorders. Recently it wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56d279e1b13b467d7b280b26911a4a86
https://pubmed.ncbi.nlm.nih.gov/33221248
https://pubmed.ncbi.nlm.nih.gov/33221248
Publikováno v:
Biochim Biophys Acta Bioenerg
Data from earlier studies showed that minor structural changes at the surface of cytochrome c oxidase, near one of the proton-input pathways (the D pathway), result in dramatically decreased activity and a lower proton-pumping stoichiometry. To furth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d08a5fd50c3e29fd97bc603bc09c880d
https://europepmc.org/articles/PMC6943178/
https://europepmc.org/articles/PMC6943178/
Autor:
Eugene Y. Zhen, Ray Rajagukguk, Martha Scharlau, Bill Durham, Lois Geren, Ling Ma, Shelagh Ferguson-Miller, Francis Millett
Publikováno v:
Biochemistry. 58(40)
The reaction between cytochrome c (Cc) and cytochrome c oxidase (CcO) was studied using horse cytochrome c derivatives labeled with ruthenium trisbipyridine at Cys 39 (Ru-39-Cc). Flash photolysis of a 1:1 complex between Ru-39-Cc and bovine CcO at a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2f7f353954e2872a568371b9d25db5a
https://pubmed.ncbi.nlm.nih.gov/31532642
https://pubmed.ncbi.nlm.nih.gov/31532642
Autor:
Ruchika Bajaj, Pascal F. Egea, Fei Li, Robert M. Stroud, Meghna Gupta, Alex J. Vecchio, Ignacio Asial, Brian C. Monk, Joana Paulino, Miles Sasha Dickinson, Shelagh Ferguson-Miller
Publikováno v:
Journal of Biological Chemistry. 296:100557
Biological membranes define the boundaries of cells and compartmentalize the chemical and physical processes required for life. Many biological processes are carried out by proteins embedded in or associated with such membranes. Determination of memb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f06d85ca396a63571173d514ff0dc79
https://doi.org/10.1016/j.jbc.2021.100557
https://doi.org/10.1016/j.jbc.2021.100557
Publikováno v:
Biochimica et biophysica acta. Bioenergetics. 1859(9)
Three mutant forms of Rhodobacter sphaeroides cytochrome c oxidase (RsCcO) were created to test for multiple K-path entry sites (E101W), the existence of an “upper ligand site” (M350 W), and the nature and binding specificity of the “lower liga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::562cc27e9e8e74f35fdf02ae8f613579
https://pubmed.ncbi.nlm.nih.gov/29626419
https://pubmed.ncbi.nlm.nih.gov/29626419
Publikováno v:
Pharmacological Research. 99:404-409
The translocator protein 18 kDa (TSPO) has been the focus of intense research by the biomedical community and the pharmaceutical industry because of its apparent involvement in many disease-related processes. These include steroidogenesis, apoptosis,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dd66c91ed887534d892fbccde565504
https://doi.org/10.1016/j.phrs.2015.03.022
https://doi.org/10.1016/j.phrs.2015.03.022
Autor:
Hye Jin Hwang, Shelagh Ferguson-Miller, Yogesh Saini, Ajith Vengellur, Scott G. Lynn, John J. LaPres, Elizabeth Grier
Publikováno v:
Biochemistry. 54:3739-3748
Hypoxia inducible factor-1 (HIF1) is a stress-responsive nuclear transcription factor that is activated with a decrease in oxygen availability. HIF1 regulates the expression of genes involved in a cell's adaptation to hypoxic stress, including those
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be98ca53fd5d40ce417ff0395f502b38
https://doi.org/10.1021/bi5012892
https://doi.org/10.1021/bi5012892