Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Shelagh D. Campbell"'
Publikováno v:
Cell Reports, Vol 33, Iss 7, Pp 108400- (2020)
Summary: The Drosophila midgut is an excellent system for characterizing cell cycle regulation in the context of tissue homeostasis. Two major progenitor cell types populate the midgut: mitotic intestinal stem cells and their post-mitotic daughters,
Externí odkaz:
https://doaj.org/article/c6d7a07a3e604a0391e196c813902f28
Publikováno v:
Biology Open, Vol 5, Iss 2, Pp 165-173 (2016)
The acquisition of nutrients is essential for maintenance of metabolic processes in all organisms. Nutritional imbalance contributes to myriad metabolic disorders that include malnutrition, diabetes and even cancer. Recently, the importance of macron
Externí odkaz:
https://doaj.org/article/85b57812ee854178a24f011e3665f5e6
Autor:
Gordon K. Chan, Armin M. Gamper, Shelagh D. Campbell, John R. Mackey, Ellen Homola, Joanne D. Smith, Won-Shik Choi, Edric J. Xiao, Amirali B. Bukhari, Cody W. Lewis
suppl figures 1-6. SF1: Myt1 knockdown sensitizes breast cells to Adavosertib; SF2: Wee1 knockdown mimics Adavosertib treatment; SF3: Adavosertib does not inhibit Myt1 activity; SF4: Adavosertib resistant cells do not prematurely enter mitosis; SF5:
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e4f4c17ce52979bc6a099cf2f397488
https://doi.org/10.1158/0008-5472.22421838
https://doi.org/10.1158/0008-5472.22421838
Autor:
Gordon K. Chan, Armin M. Gamper, Shelagh D. Campbell, John R. Mackey, Ellen Homola, Joanne D. Smith, Won-Shik Choi, Edric J. Xiao, Amirali B. Bukhari, Cody W. Lewis
Adavosertib (also known as AZD1775 or MK1775) is a small-molecule inhibitor of the protein kinase Wee1, with single-agent activity in multiple solid tumors, including sarcoma, glioblastoma, and head and neck cancer. Adavosertib also shows promising r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d66b7b25cbd74fb10ecc92c296fc247
https://doi.org/10.1158/0008-5472.c.6511047.v1
https://doi.org/10.1158/0008-5472.c.6511047.v1
Autor:
Joanne D. Smith, John R. Mackey, Won-Shik Choi, Shelagh D. Campbell, Cody W. Lewis, Armin M. Gamper, Ellen Homola, Amirali B. Bukhari, Gordon K. Chan, Edric J. Xiao
Publikováno v:
Cancer Research. 79:5971-5985
Adavosertib (also known as AZD1775 or MK1775) is a small-molecule inhibitor of the protein kinase Wee1, with single-agent activity in multiple solid tumors, including sarcoma, glioblastoma, and head and neck cancer. Adavosertib also shows promising r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf9a5bec3165882c0c5c22eaeb2f3805
https://doi.org/10.1158/0008-5472.can-19-1961
https://doi.org/10.1158/0008-5472.can-19-1961
Publikováno v:
Cell Reports, Vol 33, Iss 7, Pp 108400-(2020)
Summary: The Drosophila midgut is an excellent system for characterizing cell cycle regulation in the context of tissue homeostasis. Two major progenitor cell types populate the midgut: mitotic intestinal stem cells and their post-mitotic daughters,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cadc5ed81e697747a4e53d93ec759ddd
https://pubmed.ncbi.nlm.nih.gov/33207203
https://pubmed.ncbi.nlm.nih.gov/33207203
SUMMARYInhibitory phosphorylation of Cdk1 is a well-established mechanism for gating mitotic entry during development. However, failure to inhibit Cdk1 in adult organs causes ectopic cell division and tissue dysplasia, indicating that Cdk1 inhibition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b033b8ea1916964c05b2dbd8d3108fa0
https://doi.org/10.1101/785949
https://doi.org/10.1101/785949
Autor:
Shelagh D. Campbell, Joseph O. Ayeni
Publikováno v:
Fly. 8:140-147
Cell cycle checkpoints prevent mitosis from occurring before DNA replication and repair are completed during S and G2 phases. The checkpoint mechanism involves inhibitory phosphorylation of Cdk1, a conserved kinase that regulates the onset of mitosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52a6491c9878f87b1c75188530ec5937
https://doi.org/10.4161/19336934.2014.969147
https://doi.org/10.4161/19336934.2014.969147
Autor:
Shelagh D. Campbell, Pierre Fichelson, Joseph O. Ayeni, Michel Gho, Martin Srayko, Agnès Audibert
Publikováno v:
Development (Cambridge, England)
Development (Cambridge, England), 2016, 143 (7), pp.1160-1169. ⟨10.1242/dev.134270⟩
Development (Cambridge, England), Company of Biologists, 2016, 143 (7), pp.1160-1169. ⟨10.1242/dev.134270⟩
Development (Cambridge, England), 2016, 143 (7), pp.1160-1169. ⟨10.1242/dev.134270⟩
Development (Cambridge, England), Company of Biologists, 2016, 143 (7), pp.1160-1169. ⟨10.1242/dev.134270⟩
Developmentally regulated cell cycle arrest is a fundamental feature of neurogenesis, whose significance is poorly understood. During Drosophila sensory organ (SO) development, primary progenitor (pI) cells arrest in G2-phase for precisely defined pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb985da8e7c5d0f333e4f6abadba9950
https://hal.science/hal-01538333
https://hal.science/hal-01538333
Publikováno v:
Molecular Biology of the Cell
Drosophila Myt1 is essential for male fertility. Loss of Myt1 activity causes defective fusomes and premature centriole disengagement during premeiotic G2 phase due to lack of Myt1 inhibition of Cyclin A/Cdk1. These functions are distinct from known
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a14db9a555f2e14d93082d0590c2554
https://pubmed.ncbi.nlm.nih.gov/27170181
https://pubmed.ncbi.nlm.nih.gov/27170181