Predictive scaling of fiber-based protein A capture chromatography using mechanistic modeling.

Autor: Hahn T; Cytiva, Karlsruhe, Germany., Trunzer T; Cytiva, Karlsruhe, Germany., Rusly F; Bayer, Berkeley, California, USA., Zolyomi R; Bayer, Berkeley, California, USA., Shekhawat LK; Cytiva, Uppsala, Sweden., Malmquist G; Cytiva, Uppsala, Sweden., Hesslein A; Bayer, Berkeley, California, USA., Tjandra H; Bayer, Berkeley, California, USA.

Publikováno v: Biotechnology and bioengineering [Biotechnol Bioeng] 2024 Aug; Vol. 121 (8), pp. 2388-2399. Date of Electronic Publication: 2023 May 20.

An accelerated approach for mechanistic model based prediction of linear gradient elution ion-exchange chromatography of proteins.

Autor: Shekhawat LK; Department of Chemical Engineering, Indian Institute of Technology, Hauz Khas, New Delhi, India; Cytiva Sweden AB Björkgatan 30, 753 23 Uppsala., Tiwari A; Biomedical Engineering Center, Yamaguchi University, Tokiwadai, Ube, 755-8611, Japan; Manufacturing Technology Association of Biologics, 2-6-16, Shinkawa, Tokyo, 104-0033, Japan., Yamamoto S; Biomedical Engineering Center, Yamaguchi University, Tokiwadai, Ube, 755-8611, Japan; Manufacturing Technology Association of Biologics, 2-6-16, Shinkawa, Tokyo, 104-0033, Japan. Electronic address: shuichi@yamaguchi-u.ac.jp., Rathore AS; Department of Chemical Engineering, Indian Institute of Technology, Hauz Khas, New Delhi, India. Electronic address: asrathore@biotechcmz.com.

Publikováno v: Journal of chromatography. A [J Chromatogr A] 2022 Sep 13; Vol. 1680, pp. 463423. Date of Electronic Publication: 2022 Aug 15.

Design of experiments applications in bioprocessing: Chromatography process development using split design of experiments.

Autor: Shekhawat LK; Dept. of Chemical Engineering, Indian Inst. of Technology, Hauz Khas, New Delhi, India., Godara A; Dept. of Chemical Engineering, Indian Inst. of Technology, Hauz Khas, New Delhi, India., Kumar V; Dept. of Chemical Engineering, Indian Inst. of Technology, Hauz Khas, New Delhi, India., Rathore AS; Dept. of Chemical Engineering, Indian Inst. of Technology, Hauz Khas, New Delhi, India.

Publikováno v: Biotechnology progress [Biotechnol Prog] 2019 Jan; Vol. 35 (1), pp. e2730. Date of Electronic Publication: 2018 Nov 04.

Process development in the Quality by Design paradigm: Modeling of Protein A chromatography resin fouling.

Autor: Shekhawat LK; Department of Chemical Engineering, Indian Institute of Technology, Hauz Khas, New Delhi, India., Pathak M; Department of Chemical Engineering, Indian Institute of Technology, Hauz Khas, New Delhi, India., Sakar J; Department of Chemical Engineering, Indian Institute of Technology, Hauz Khas, New Delhi, India., Rathore AS; Department of Chemical Engineering, Indian Institute of Technology, Hauz Khas, New Delhi, India. Electronic address: asrathore@biotechcmz.com.

Publikováno v: Journal of chromatography. A [J Chromatogr A] 2018 Oct 05; Vol. 1570, pp. 56-66. Date of Electronic Publication: 2018 Jul 25.

CFD of mixing of multi-phase flow in a bioreactor using population balance model.

Autor: Sarkar J; Department of Chemical Engineering, Indian Institute of Technology Delhi, Hauz Khas, New Delhi, India., Shekhawat LK; Department of Chemical Engineering, Indian Institute of Technology Delhi, Hauz Khas, New Delhi, India., Loomba V; Department of Chemical Engineering, Indian Institute of Technology Delhi, Hauz Khas, New Delhi, India., Rathore AS; Department of Chemical Engineering, Indian Institute of Technology Delhi, Hauz Khas, New Delhi, India.

Publikováno v: Biotechnology progress [Biotechnol Prog] 2016 May; Vol. 32 (3), pp. 613-28. Date of Electronic Publication: 2016 Feb 29.