Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Shekhar Viswanath"'
Autor:
Shekhar Viswanath, Shankarraman Vaidyaraman, Jon Dieringer, Chrysanthos E. Gounaris, Nikolaos H. Lappas, Steve Guntz, Sal Garcia-Munoz, Hua Wang
Publikováno v:
INFORMS Journal on Applied Analytics. 51:262-279
The research and development (R&D) management in any major research pharmaceutical company is constantly faced with the need to make complicated activity scheduling and resource allocation decisions, as they carry out scientific work to develop new t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f06c983ac47acc78eecc60feeb742a0
https://doi.org/10.1287/inte.2021.1074
https://doi.org/10.1287/inte.2021.1074
Autor:
Shekhar Viswanath, Steve Guntz, Chrysanthos E. Gounaris, Shankarraman Vaidyaraman, Jon Dieringer, Hua Wang
Publikováno v:
Journal of Pharmaceutical Innovation. 17:155-169
This contribution is the first example of a small molecule pharmaceutical product development ontology. This ontology allows the portfolio-wide visualization of the small molecule pharmaceutical development business as a network of decisions and acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9aa6196898f922d7aa12ea290fe18f9b
https://doi.org/10.1007/s12247-020-09505-6
https://doi.org/10.1007/s12247-020-09505-6
Publikováno v:
Journal of Pharmaceutical Innovation. 16:302-316
Due to the exceptionally high standards for accuracy and data integrity in scientific regulatory reporting, it is vital that any tool that aims to streamline this process is as efficient or more in gathering data as a team of scientists, without high
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b4a4eb18f01c60384458fab6ebcde13
https://doi.org/10.1007/s12247-020-09449-x
https://doi.org/10.1007/s12247-020-09449-x
Publikováno v:
Organic Process Research & Development. 18:1391-1399
This paper presents a case study where kinetic models were used to drive process development of an amination reaction in a continuous process. The kinetic model was first used to optimize the process by minimizing impurity formation. Then, the kineti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7596df141ddd82ecfda983be9a961582
https://doi.org/10.1021/op500016n
https://doi.org/10.1021/op500016n
Publikováno v:
Organic Process Research & Development. 17:1300-1310
Batch reactive distillations are commonly used unit operations in the pharmaceutical industry to drive chemical equilibrium reactions to completion. Their scale-up and transfer to manufacturing is not straightforward due to the interplay of scale dep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2fec3a368937e90686e7f05b733bbaa
https://doi.org/10.1021/op4001127
https://doi.org/10.1021/op4001127
Autor:
Edward Mark Davis, Shekhar Viswanath
Publikováno v:
Organic Process Research & Development. 16:1360-1370
Mathematical models of dose controlled reactions based on heat flow data(1, 2) are quite common and well developed; however, such predictions for nondose controlled reactions from heat flow data are difficult, requiring extensive study of the kinetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c25860ff4d363e0ce7bd16353f7decfe
https://doi.org/10.1021/op300036p
https://doi.org/10.1021/op300036p
Publikováno v:
Pharmaceutical research. 30(1)
Salts of active pharmaceutical ingredients are often used to enhance solubility, dissolution rate, or take advantage of other improved solid-state properties. The selected form must be maintained during processing and shelf-life to ensure quality. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::849f93212e78f30ab0712bac96516703
https://pubmed.ncbi.nlm.nih.gov/22918819
https://pubmed.ncbi.nlm.nih.gov/22918819
Publikováno v:
Journal of pharmaceutical sciences. 97(3)
A modification of wet agglomeration technique is developed and demonstrated by agglomerative crystallization process for a nonapeptide (ABT-510) to improve processing of needle like crystals. Our procedure involves exploiting partial miscibility of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1ff9328c8351da8fdd980bad412d209
https://pubmed.ncbi.nlm.nih.gov/17683060
https://pubmed.ncbi.nlm.nih.gov/17683060