Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Shekeba Ahmadyar"'
Autor:
Qi Liu, Chien-Hung Chou, Eda Canales, Roman Sakowicz, Steven Bondy, Tomas Cihlar, Albert Liclican, Diana M. Brainard, Anita Niedziela-Majka, William Rowe, Nikolai Novikov, Shekeba Ahmadyar, John R. Somoza, Randall L. Halcomb, Cheryl K. McDonald, Carina E. Cannizzaro, Nicolas Margot, Debi Jin, George Stepan, Qiaoyin Wu, Eric Hu, Judy Mwangi, Stephanie A. Leavitt, Todd C. Appleby, Robert L. Anderson, Scott E. Lazerwith, Schroeder Scott D, Tse Winston C, Gediminas Brizgys, Rebecca Begley, Yili Xu, Scott Sellers, Scott A. Wolckenhauer, Wesley I. Sundquist, Derek Hansen, Philip Morganelli, Andrew Mulato, Sheila Clancy, Xiaohong Liu, Anna Chiu, Eric S. Daar, Renee R. Ram, S. Swaminathan, Anne E. Chester, Melanie H. Wong, Ya-Pei Liu, John O. Link, Michael Graupe, Luong K. Tsai, Christian Callebaut, Latesh Lad, William E. Lee, Rujuta A. Bam, Terrence Z. Cai, Bing Lu, John K. Ling, Roland D. Saito, Magdeleine Hung, Armando G. Villaseñor, Peter Ruane, Nikos Pagratis, Martin S. Rhee, David Koditek, Gordon Crofoot, Giuseppe A. Papalia, Stephen R. Yant, Rob Hyland, Helen Yu, Jim Zheng, Jennifer R. Zhang, Gary I. Sinclair, Jiayao Li, Eric Singer
Publikováno v:
Nature
Oral antiretroviral agents provide life-saving treatments for millions of people living with HIV, and can prevent new infections via pre-exposure prophylaxis1–5. However, some people living with HIV who are heavily treatment-experienced have limite
Autor:
Melanie H. Wong, Helen Yu, Daniel Gonik, Derek Hansen, Wesley I. Sundquist, Debi Jin, Anita Niedziela-Majka, Nikolai Novikov, William M. McDougall, Shekeba Ahmadyar, Albert Liclican, Jill M. Perreira, Andrew Mulato, George Stepan, Jennifer R. Zhang, Bing Lu, Magdeleine Hung, Giuseppe A. Papalia, Renee R. Ram, John O. Link, Kevin Chou, Abraham L. Brass, Eric E. Paoli, Stephen R. Yant, Jim Zheng, Eric Singer, Eric Hu, Tomas Cihlar, Schroeder Scott D, Tse Winston C
Publikováno v:
Nat Med
People living with HIV (PLWH) have expressed concern about the life-long burden and stigma associated with taking pills daily and can experience medication fatigue that might lead to suboptimal treatment adherence and the emergence of drug-resistant
Autor:
George Stepan, Shekeba Ahmadyar, Michel Perron, Brian E. Schultz, Helen Yu, Ona Barauskas, Roman Sakowicz, Yili Xu, Yeojin Park, Jason K. Perry, Joy Y. Feng, Adrian S. Ray, Krista McCutcheon, Darius Babusis
Publikováno v:
Antimicrobial Agents and Chemotherapy
Toxicity has emerged during the clinical development of many but not all nucleotide inhibitors (NI) of hepatitis C virus (HCV). To better understand the mechanism for adverse events, clinically relevant HCV NI were characterized in biochemical and ce
Autor:
Schroeder Scott D, Tse Winston C, Raju Subramanian, Anna Chiu, Tomas Cihlar, George Stepan, William Rowe, Shekeba Ahmadyar, Kelly Wang, Tiffany Chan, John O. Link, Jim Zheng, Judy Mwangi, Bing Lu, Stephen R. Yant
Publikováno v:
Open Forum Infectious Diseases
Background GS-CA2, an analog of GS-CA1, is a novel and selective inhibitor of HIV-1 capsid function. Safety and pharmacokinetics (PK) of GS-CA2 is currently being evaluated in healthy human subjects. Herein, we present the anti-HIV activity and noncl
Autor:
Angela Tsai, George Stepan, Nikos Pagratis, Gregg S. Jones, Bailey J Dickey, Monica E Morales, Roger G. Linington, Gabriel Navarro, Tomas Cihlar, Manuel Tsiang, Romas Geleziunas, Helen Yu, Brian León, Shekeba Ahmadyar, Tiffany Barnes, Yang Tian
Publikováno v:
Organic Letters. 17:262-265
Screening of a marine natural products library afforded three new analogues of the tetronic acid containing polyketide abyssomicin family and identified abyssomicin 2 as a selective reactivator of latent HIV virus. Examination of the mode of action o
Autor:
N. Pagratis, Simon Lebek, Shekeba Ahmadyar, Lars S. Maier, B. Flörchinger, Charlotte M. Lücht, D Tarnowski, Christof Schmid, Julian Mustroph, Stefan Wagner, B. Marchand, Simon Schopka, Luiz Belardinelli, A. Plößl, W.K. Hung, York Zausig, Maria J. Baier, Dmitry Koltun
Publikováno v:
Journal of molecular and cellular cardiology. 118
Rationale Ca/calmodulin-dependent protein kinase II (CaMKII) was shown to increase diastolic sarcoplasmic reticulum (SR) Ca leak, which can result in delayed afterdepolarizations and triggered arrhythmias. Since increased CaMKII expression and activi