Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Shekar Chelur"'
Autor:
Sarah Juel Paulsen, Leif Kongskov Larsen, Gitte Hansen, Shekar Chelur, Philip Just Larsen, Niels Vrang
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88227 (2014)
Stimulation of the G protein coupled receptor GPR120 has been shown to have anti-inflammatory and insulin-sensitizing effects, to promote glucagon like peptide-1 (GLP-1) secretion, and to play a key role in sensing dietary fat and control energy bala
Externí odkaz:
https://doaj.org/article/27b213cc4d2845e2b6f2ee9334ff1d51
Autor:
Pekka J. Kallio, Murali Ramachandra, Nanduri Srinivas, Ravi K. Ujjinamatada, Subhendu Mukherjee, Samiulla Dhodheri, Thomas Anthony, Nagaraj Gowda, Rashmi Nair, Jiju Mani, Raghuveer K. Ramachandra, Kishore Narayanan, Shekar Chelur, Srinivasan Rajagopalan, Susanta Samajdar, Timo Korjamo, Riikka Oksala, Stefan Karlsson, Gerd Wohlfahrt, Tero Linnanen, Mari L. Björkman, Tarja Ikonen, Anu-Maarit Moilanen, Tim H. Holmström
Supplementary table S1 shows the effect of ODM-203 in a large kinase panel. Supplementary figure S1 shows how ODM-203 is synthesized. Supplementary figure S2 shows the effect of ODM-203 on FRS2 phosphorylation. Supplement figure S3 shows the effect o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01a4b40ece62b019671a48c99c70cd8b
https://doi.org/10.1158/1535-7163.22505722
https://doi.org/10.1158/1535-7163.22505722
Autor:
Pekka J. Kallio, Murali Ramachandra, Nanduri Srinivas, Ravi K. Ujjinamatada, Subhendu Mukherjee, Samiulla Dhodheri, Thomas Anthony, Nagaraj Gowda, Rashmi Nair, Jiju Mani, Raghuveer K. Ramachandra, Kishore Narayanan, Shekar Chelur, Srinivasan Rajagopalan, Susanta Samajdar, Timo Korjamo, Riikka Oksala, Stefan Karlsson, Gerd Wohlfahrt, Tero Linnanen, Mari L. Björkman, Tarja Ikonen, Anu-Maarit Moilanen, Tim H. Holmström
Alterations in the gene encoding for the FGFR and upregulation of the VEGFR are found often in cancer, which correlate with disease progression and unfavorable survival. In addition, FGFR and VEGFR signaling synergistically promote tumor angiogenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0ba784729eaeca665669c7e27a87040
https://doi.org/10.1158/1535-7163.c.6538162.v1
https://doi.org/10.1158/1535-7163.c.6538162.v1
Autor:
Ramulu Poddutoori, Kimberly Aardalen, Kiran Aithal, Sanjeev Surendranath Barahagar, Charamanna Belliappa, Mark Bock, Shekar Chelur, Andrea Gerken, Sreevalsam Gopinath, Bjoern Gruenenfelder, Michael Kiffe, Maithreyi Krishnaswami, John Langowski, Sudharshan Madapa, Kishore Narayanan, Chetan Pandit, Sunil Kumar Panigrahi, Mark Perrone, Ravi Kumar Potakamuri, Murali Ramachandra, Anuradha Ramanathan, Rita Ramos, Emine Sager, Susanta Samajdar, Hosahalli S. Subramanya, Devaraja Seethappa Thimmasandra, Eleni Venetsanakos, Henrik Möbitz
Publikováno v:
Journal of Medicinal Chemistry. 65:4350-4366
Mutations in MEK1/2 have been described as a resistance mechanism to BRAF/MEK inhibitor treatment. We report the discovery of a novel ATP-competitive MEK1/2 inhibitor with efficacy in wildtype (WT) and mutant MEK12 models. Starting from a HTS hit, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7df3980bf0fc9797eb2d0401e08b1d0f
https://doi.org/10.1021/acs.jmedchem.1c02192
https://doi.org/10.1021/acs.jmedchem.1c02192
Autor:
Girish Daginakatte, Chandrasekhar Abbineni, Saravanan Thiyagarajan, Mamon Dey, Aravind Basavaraj, Amit Dhudashiya, Sivapriya Marappan, Sandeep Sadashiv Patil, Naveen Kumar R, Raghavendra NR, Avinash Kumar, Uma Bharathi B, Girish Renukappa, Venkata Siva Reddy, Amith A, Lavanya CS, Subhendu Mukherjee, Samiulla DS, Thomas Antony, Rajesh Eswarappa, Kavitha Nellore, Shekar Chelur, Murali Ramachandra, Susanta Samajdar
Publikováno v:
Regular and Young Investigator Award Abstracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::575db11a90ff413fb3e2f86f22132e0e
https://doi.org/10.1136/jitc-2022-sitc2022.1313
https://doi.org/10.1136/jitc-2022-sitc2022.1313
Autor:
Chandrasekhar Abbineni, Saravanan Thiyagarajan, Aravind A B, Amit A Dhudashiya, Sivapriya Marappan, Naveen Kumar R, Raghavendra N R, Mamon Dey, Avinash Kumar, Uma Bharathi B V, Girish Aggunda Renukappa, N Venkata Siva Reddy, Asha Babu, Aakanksha J Shetty, Amith A, Narasimha Rao K, Suraj T Gore, Mahaboobi Jaleel, Ramesh S Senaiar, Vijaya Shankar Nataraj, Subhendu Mukherjee, Samiulla D S, Thomas Antony, Girish Daginakatte, Rajesh Eswarappa, Kavitha Nellore, Shekar Chelur, Murali Ramachandra, Susanta Samajdar
Publikováno v:
Cancer Research. 82:4114-4114
Background: E1A binding protein (p300) and its paralog CREB binding protein (CBP or CREBBP) are ubiquitously expressed acetyl transferases (HAT) that also act as co-activators for number of transcription factors including HIF1a, BRCA-1, p53, c-Myc an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff3782f5cb8cc2460d6faa5ae6a85023
https://doi.org/10.1158/1538-7445.am2022-4114
https://doi.org/10.1158/1538-7445.am2022-4114
Autor:
Chandrasekhar Abbineni, Leena Khare, Bilash Kuila, Abdul Rawoof Khaji, Dhaytadak Bhagwan Mahadeo, Sandeep Vitthal Dukare, Bhagya M S Kumar, Suraj T Gore, Vijay Kamal Ahuja, Amit A Dhudashiya, Raghavendra N R, Nagesh Gowda, Charamanna K B, Kiran Aithal B, Samiulla D S, Subhendu Mukherjee, Thomas Antony, Sanjeev Giri, Shekar Chelur, Kavitha Nellore, Girish Daginakatte, Murali Ramachandra, Susanta Samajdar
Publikováno v:
Cancer Research. 82:3729-3729
Background: The BAF (SWI/SNF) chromatin remodeling complex comprises of two mutually exclusive ATPases, SMARCA2 (BRM) and SMARCA4 (BRG1), that affect the mobilization and positioning of nucleosomes on DNA and thereby regulates important cellular func
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43eab02d1cdc629559ec0922191e44b3
https://doi.org/10.1158/1538-7445.am2022-3729
https://doi.org/10.1158/1538-7445.am2022-3729
Autor:
Lakshmi Narayan Kaza, Thomas Anthony, Sunil Kumar Pnaigrahi, Aditya Kiran Gatta, Kiran Aithal, Pravin Pise, Vijay Kamal Ahuja, Narasimha Rao Krishnamurthy, Sanjeev Giri, Vinayak Khairnar, Narasimha Raju Kalidindi, Murali Ramachandra, KB Charamannna, Nirbhay Kumar Tiwari, Susanta Samajdar, Vijaya Shankar Nataraj, Dinesh Chikkanna, Shekar Chelur, Kavitha Nellore, Manoj Pothuganti, Sandeep Patil, DS Samiulla, Leena Khare Satyam
Publikováno v:
Cancer Research. 81:1266-1266
Dysregulated fatty acid metabolism is thought to be a hallmark of cancer, wherein fatty acids function both as an energy source and as signals for enzymatic and transcriptional networks contributing to malignancy. Fatty acid-binding protein 5 (FABP5)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0cc315b02b322125cd0c1358d889a71
https://doi.org/10.1158/1538-7445.am2021-1266
https://doi.org/10.1158/1538-7445.am2021-1266
Autor:
Samiulla D S, Shekar Chelur, Pathange Hemasankar, Mikko Myllymäki, Kavitha Nellore, Mahaboobi Jaleel, Naveen Kumar R, Prasad Yadlapalli, Aravind A B, Chandrasekhar Abbineni, Murali Ramachandra, Venkata Siva N. Reddy, Ramesh S. Senaiar, Susanta Samajdar, Subhendu Mukherjee, Saravanan Thiyagarajan, Raghavendra N R, Sivapriya Marappan, Gerd Wohlfahrt, Thomas Antony, Girish Aggunda Renukappa, Chandranath D. Naik, Asha Babu, Girish Daginakatte, Mamon Dey, Akhila Srinivas, Suraj T Gore
Publikováno v:
Cancer Research. 81:1143-1143
Background: E1A binding protein (p300) and its paralog CREB binding protein (CBP or CREBBP) are ubiquitously expressed acetyl transferases (HAT) that also act as co-activators for number of transcription factors including HIF1a, BRCA-1, p53, c-Myc an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::576694e462ade64801981b26dc54a029
https://doi.org/10.1158/1538-7445.am2021-1143
https://doi.org/10.1158/1538-7445.am2021-1143
Autor:
Subhendu Mukherjee, Susanta Samajdar, Sandeep Vitthal Dukare, Murali Ramachandra, Girish Daginakatte, Sanjeev Giri, Chandrasekhar Abbineni, M. R Sreevidya, Vijay Kamal Ahuja, Kiran Aithal, Charamanna Kb, Thomas Antony, DS Samiulla, Rakesh P. Nankar, Khaji Abdul Rawoof, Megha Goyal, Leena Khare Satyam, Suraj T. Gore, Bilash Kuila, Shekar Chelur, Ashok Ettam, Kavitha Nellore
Publikováno v:
Cancer Research. 81:1144-1144
Background: SMARCA2 (BRM) and SMARCA4 (BRG1) are two mutually exclusive DNA-dependent ATPases of the SWI/SNF complex, which function in mobilizing nucleosomes to regulate transcription, DNA replication/repair and chromosome dynamics. SMARCA4 is known
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14183647be6ef9b5b03e0005b4c444e4
https://doi.org/10.1158/1538-7445.am2021-1144
https://doi.org/10.1158/1538-7445.am2021-1144