Engineering Toxoplasma gondii secretion systems for intracellular delivery of multiple large therapeutic proteins to neurons.

Autor: Bracha S; Department of Neurobiology, Biochemistry and Biophysics, Wise Faculty of Life Sciences and Sagol School for Neuroscience, Tel Aviv University, Tel Aviv, Israel. shaharbr@mit.edu.; McGovern Institute for Brain Research, MIT, Cambridge, MA, USA. shaharbr@mit.edu., Johnson HJ; Neuroscience Graduate Interdisciplinary Program, University of Arizona, Tucson, AZ, USA.; Departments of Neurology and Immunobiology, College of Medicine, and BIO5 Institute, University of Arizona, Tucson, AZ, USA., Pranckevicius NA; Centre for Parasitology, School of Infection and Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK., Catto F; Institute of Neuropathology, University Hospital Zurich, University of Zurich, Zurich, Switzerland., Economides AE; Institute of Neuropathology, University Hospital Zurich, University of Zurich, Zurich, Switzerland., Litvinov S; Computational Science and Engineering Laboratory, School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA., Hassi K; Centre for Parasitology, School of Infection and Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK., Rigoli MT; Human Technopole, Milan, Italy.; Department of Experimental Oncology, European Institute of Oncology IRCCS, Milan, Italy.; Department of Oncology and Hemato-oncology, University of Milan, Milan, Italy., Cheroni C; Human Technopole, Milan, Italy.; Department of Oncology and Hemato-oncology, University of Milan, Milan, Italy., Bonfanti M; Human Technopole, Milan, Italy., Valenti A; Human Technopole, Milan, Italy.; Department of Experimental Oncology, European Institute of Oncology IRCCS, Milan, Italy.; Department of Oncology and Hemato-oncology, University of Milan, Milan, Italy., Stucchi S; Human Technopole, Milan, Italy.; Department of Experimental Oncology, European Institute of Oncology IRCCS, Milan, Italy.; Department of Oncology and Hemato-oncology, University of Milan, Milan, Italy., Attreya S; Undergraduate Biology Research Program, University of Arizona, Tucson, AZ, USA., Ross PD; Institute of Neuroscience and Psychology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK., Walsh D; Centre for Parasitology, School of Infection and Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK., Malachi N; Epeius Pharma, Ness Ziona, Israel., Livne H; Epeius Pharma, Ness Ziona, Israel., Eshel R; Epeius Pharma, Ness Ziona, Israel., Krupalnik V; Epeius Pharma, Ness Ziona, Israel., Levin D; Epeius Pharma, Ness Ziona, Israel., Cobb S; Institute of Neuroscience and Psychology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK., Koumoutsakos P; Computational Science and Engineering Laboratory, School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA., Caporale N; Human Technopole, Milan, Italy.; Department of Experimental Oncology, European Institute of Oncology IRCCS, Milan, Italy.; Department of Oncology and Hemato-oncology, University of Milan, Milan, Italy., Testa G; Human Technopole, Milan, Italy. giuseppe.testa@fht.org.; Department of Experimental Oncology, European Institute of Oncology IRCCS, Milan, Italy. giuseppe.testa@fht.org.; Department of Oncology and Hemato-oncology, University of Milan, Milan, Italy. giuseppe.testa@fht.org., Aguzzi A; Institute of Neuropathology, University Hospital Zurich, University of Zurich, Zurich, Switzerland. adriano.aguzzi@usz.ch., Koshy AA; Departments of Neurology and Immunobiology, College of Medicine, and BIO5 Institute, University of Arizona, Tucson, AZ, USA. akoshy@arizona.edu., Sheiner L; Centre for Parasitology, School of Infection and Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK. lilach.sheiner@glasgow.ac.uk., Rechavi O; Department of Neurobiology, Biochemistry and Biophysics, Wise Faculty of Life Sciences and Sagol School for Neuroscience, Tel Aviv University, Tel Aviv, Israel. odedrechavi@gmail.com.

Publikováno v: Nature microbiology [Nat Microbiol] 2024 Aug; Vol. 9 (8), pp. 2051-2072. Date of Electronic Publication: 2024 Jul 29.

Plasmodium falciparum Mitochondrial Complex III, the Target of Atovaquone, Is Essential for Progression to the Transmissible Sexual Stages.

Autor: Sheokand PK; Wellcome Centre for Integrative Parasitology, School of Infection and Immunity, University of Glasgow, Glasgow G12 8TA, UK., Pradhan S; Wellcome Centre for Integrative Parasitology, School of Infection and Immunity, University of Glasgow, Glasgow G12 8TA, UK., Maclean AE; Wellcome Centre for Integrative Parasitology, School of Infection and Immunity, University of Glasgow, Glasgow G12 8TA, UK., Mühleip A; Wellcome Centre for Integrative Parasitology, School of Infection and Immunity, University of Glasgow, Glasgow G12 8TA, UK., Sheiner L; Wellcome Centre for Integrative Parasitology, School of Infection and Immunity, University of Glasgow, Glasgow G12 8TA, UK.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2024 Aug 26; Vol. 25 (17). Date of Electronic Publication: 2024 Aug 26.

Pyrimidine salvage in Toxoplasma gondii as a target for new treatment.

Autor: Elati HAA; School of Infection and Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.; Department of Pharmacology and Toxicology, Pharmacy College, University of Elmergib, Al Khums, Libya., Goerner AL; Larner College of Medicine at The University of Vermont, Department of Microbiology and Molecular Genetics, Burlington, VT, United States., Martorelli Di Genova B; Larner College of Medicine at The University of Vermont, Department of Microbiology and Molecular Genetics, Burlington, VT, United States., Sheiner L; School of Infection and Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.; Wellcome Centre for Integrative Parasitology, University of Glasgow, Glasgow, United Kingdom., de Koning HP; School of Infection and Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.

Publikováno v: Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2023 Dec 15; Vol. 13, pp. 1320160. Date of Electronic Publication: 2023 Dec 15 (Print Publication: 2023).

Heteroscedastic Nonlinear Regression

Autor: Beal, S. L., Sheiner, L. B.

Publikováno v: Technometrics, 1988 Aug 01. 30(3), 327-338.

Externí odkaz: https://www.jstor.org/stable/1270087

The mystery of massive mitochondrial complexes: the apicomplexan respiratory chain.

Autor: Maclean AE; Wellcome Centre for Integrative Parasitology, University of Glasgow, Glasgow, UK., Hayward JA; Research School of Biology, Australian National University, Canberra, Australia., Huet D; Center for Tropical & Emerging Diseases, University of Georgia, Athens, GA, USA; Department of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, GA, USA., van Dooren GG; Research School of Biology, Australian National University, Canberra, Australia., Sheiner L; Wellcome Centre for Integrative Parasitology, University of Glasgow, Glasgow, UK. Electronic address: Lilach.Sheiner@glasgow.ac.uk.

Publikováno v: Trends in parasitology [Trends Parasitol] 2022 Dec; Vol. 38 (12), pp. 1041-1052. Date of Electronic Publication: 2022 Oct 24.