Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Sheila W. Weir"'
Autor:
Arthur H. Weston, Sheila W. Weir
Publikováno v:
Journal of Pharmacological Methods. 19:243-252
A comparison has been made of methods utilizing LaCl3 or EGTA for the determination of changes in Ca2+ influx into vascular smooth muscle. Stimulation of 45Ca2+ influx through voltage-operated channels using KCl and blockade of this effect with verap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10d2b04e57752b2206a61770f6804976
https://doi.org/10.1016/0160-5402(88)90026-5
https://doi.org/10.1016/0160-5402(88)90026-5
Autor:
Arthur H. Weston, Sheila W. Weir
Publikováno v:
British Journal of Pharmacology. 88:121-128
The effects of the antihypertensive agent BRL 34915 on a variety of responses of the aorta and portal vein of the rat have been compared with those of nicorandil. On portal vein, BRL 34915 (0.01-50 X 10(-6) M) and nicorandil (0.1-500 X 10(-6) M) abol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bcc80f09e89893c1fc44a8fe772da52
https://doi.org/10.1111/j.1476-5381.1986.tb09478.x
https://doi.org/10.1111/j.1476-5381.1986.tb09478.x
Publikováno v:
Scopus-Elsevier
The extracellular Ca2+ dependence of agonist stimulation of vascular smooth muscle (VSM) has been investigated in rat cultured aortic smooth muscle cells (SMCs) and isolated mesenteric resistance vessels (MRVs). Agonists such as [Arg8]vasopressin (AV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e933bb8e4407ac5d3dc15c61ae34ba0a
https://doi.org/10.1097/00005344-198900146-00012
https://doi.org/10.1097/00005344-198900146-00012
Autor:
Roger C. Small, Sheila W. Weir, Arthur H. Weston, K.M. Bray, S.G. Taylor, D. T. Newgreen, J. S. Southerton
Publikováno v:
British Journal of Pharmacology. 91:421-429
The effects of pinacidil have been compared with those of glyceryl trinitrate (GTN) using the aorta and portal vein of the rat and the trachealis and taenia caeci of the guinea-pig. In aorta, both pinacidil and GTN inhibited responses to noradrenalin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56225edc1f4acdf2557b4ae8db781a1f
https://doi.org/10.1111/j.1476-5381.1987.tb10297.x
https://doi.org/10.1111/j.1476-5381.1987.tb10297.x
Publikováno v:
Journal of Cardiovascular Pharmacology. 12:S10-S15
The effects of noradrenaline (NA) on rat, rabbit, and human mesenteric resistance vessels (MRVs) in Ca2+-free medium have been compared. The maximum tension obtained in the absence of extracellular Ca2+ is least and is lost most rapidly with time in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5af33ce42cae9b6f9c2707d40aa005f
https://doi.org/10.1097/00005344-198812006-00005
https://doi.org/10.1097/00005344-198812006-00005
Publikováno v:
British Journal of Pharmacology. 98:817-826
1. The effects of fractionated Leiurus quinquestriatus hebraeus venom on cromakalim-induced 86Rb+ efflux in rabbit aortic smooth muscle were examined. 2. Crude venom (0.1-30 micrograms ml-1) produced a concentration-dependent decrease of 1 microM cro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56172365ed8881990a9af89301758782
https://doi.org/10.1111/j.1476-5381.1989.tb14610.x
https://doi.org/10.1111/j.1476-5381.1989.tb14610.x
Publikováno v:
British Journal of Pharmacology. 95:741-752
1. Contractile responses of rabbit aortic rings elicited by KCl-depolarization, angiotensin II (AII), 5-hydroxytryptamine (5-HT) and noradrenaline (NA) have been investigated in the presence of cromakalim (BRL 34915) and isradipine (PN 200-110). 2. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c35d5921ad74290c4af804b197f4818e
https://doi.org/10.1111/j.1476-5381.1988.tb11700.x
https://doi.org/10.1111/j.1476-5381.1988.tb11700.x
Autor:
Sheila W. Weir, Arthur H. Weston
BRL 34915 (4-64 X 10(-7) M), isoprenaline (0.5-32 X 10(-8) M) and nicorandil (4-64 X 10(-6) M) produced a slowly-developing relaxation of spontaneous tone of the guinea-pig taenia caeci; with no after-contraction on washout. These inhibitory response
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b14c6f67072707067fb6d0bec2d8fd2e
https://europepmc.org/articles/PMC1917124/
https://europepmc.org/articles/PMC1917124/
Publikováno v:
British journal of pharmacology. 88(1)
The effects of the novel anti-hypertensive agent BRL 34915, (+/-) 6-cyano-3,4-dihydro-2,2-dimethyl-trans-4-(2-oxo-1-pyrrolidyl)-2H-b enzo[b]pyran-3-ol, have been compared with those of verapamil on rat isolated portal vein. BRL 34915 produced a conce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::653cae774e839a78e189c30fb6f4a74e
https://pubmed.ncbi.nlm.nih.gov/3708211
https://pubmed.ncbi.nlm.nih.gov/3708211
Publikováno v:
Scopus-Elsevier
The effects of endothelin-1 (ET-1) on tension and membrane potential in rat isolated mesenteric resistance vessels (MRVs) and on 45Ca influx, 45Ca efflux, inositol-1,4,5-triphosphate (IP3) production, and cytoplasmic Ca2+ concentration ([Ca2+]1) in c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8a8ea04f9d1be131b19820e52f06242
https://pubmed.ncbi.nlm.nih.gov/2473323
https://pubmed.ncbi.nlm.nih.gov/2473323