Výsledky vyhledávání - "Sheila Timmons"

Peptide-directed Suppression of a Pro-inflammatory Cytokine Response

Autor: Jacek Hawiger, Sheila Timmons, Robert D. Collins, Ruth Ann Veach, Daniel N. Robinson, Danya Liu, Xue Yan Liu

Publikováno v: Journal of Biological Chemistry. 275:16774-16778

Signal-dependent nuclear translocation of transcription factor nuclear factor kappaB (NF-kappaB) is required for the activation of downstream target genes encoding the mediators of immune and inflammatory responses. To inhibit this inducible signalin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::360698ad8b3e9949c27759d826eedf91
https://doi.org/10.1074/jbc.c000083200

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IκB Kinase Complex Is an Intracellular Target for Endotoxic Lipopolysaccharide in Human Monocytic Cells

Autor: Sheila Timmons, Ruth Ann Veach, Dean W. Ballard, Xue Yan Liu, Jacek Hawiger

Publikováno v: Scopus-Elsevier

Endotoxic lipopolysaccharide (LPS) is a proinflammatory agonist produced by gram-negative bacteria and a contributor to the majority of the 400,000 septic shock cases recorded annually in US hospitals. The primary target cells for LPS are monocytes a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7934675272d069c06905c387c576ebe0
https://doi.org/10.1182/blood.v94.5.1711

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Mouse Col18a1 is expressed in a tissue-specific manner as three alternative variants and is localized in basement membrane zones

Autor: Sheila Timmons, Y. Muragaki, C. M. Griffith, Suk P. Oh, Bjorn R. Olsen, Thomas Quertermous, Bahaa Fadel

Publikováno v: Proceedings of the National Academy of Sciences. 92:8763-8767

We have isolated overlapping cDNAs encoding the N-terminal non-triple-helical region of mouse alpha 1(XVIII) collagen and shown that three different variants of alpha 1(XVIII) collagen exist. Each of the three variants shows characteristic tissue-spe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::597be4086fc5d1b47f4dee5c01481b99
https://doi.org/10.1073/pnas.92.19.8763

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Isolation and sequencing of cDNAs for proteins with multiple domains of Gly-Xaa-Yaa repeats identify a distinct family of collagenous proteins

Autor: Sheila Timmons, Bjorn R. Olsen, Suk P. Oh, Yusuke Kamagata, Yasuteru Muragaki, Akira Ooshima

Publikováno v: Proceedings of the National Academy of Sciences. 91:4229-4233

We have isolated overlapping mouse cDNAs encoding a collagenous polypeptide that we have designated alpha 1(XVIII) collagen. Nucleotide sequence analysis shows that alpha 1(XVIII) collagen contains 10 triple-helical domains separated and flanked by n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1430e8d80b5177bf087d15694faf713
https://doi.org/10.1073/pnas.91.10.4229

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A .beta.-turn is present in the 392-411 segment of the human fibrinogen .gamma.-chain. Effects of structural changes in this segment on affinity to antibody 4A5

Autor: Sheila Timmons, Jacek Hawiger, Gary R. Matsueda, Michael Blumenstein

Publikováno v: Biochemistry. 31:10692-10698

The interaction between fibrinogen gamma-peptide 392-411, LTIGEGQQHHLGGAKQAGDV, and monoclonal antibody 4A5, an antibody with a high affinity for both for the peptide and native fibrinogen, is being studied as a model for peptide-antibody interaction

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e6389af830ebbdfe96b0633bdd0e300
https://doi.org/10.1021/bi00159a008

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A modified Arg-Asp-Val (RDV) peptide derived during the synthesis of Arg-Glu-Asp-Val (REDV), a tetrapeptide derived from an alternatively spliced site in fibronectin, inhibits the binding of fibrinogen, fibronectin, von Willebrand factor and vitronectin to activated platelets

Autor: Charles S. Chen, Perumal Thiagarajan, Ioannis A. Papayannopoulos, Sheila Timmons, Shan-Ho Chou

Publikováno v: Biochimica et Biophysica Acta (BBA) - General Subjects. 1075:237-247

Characterization of a side-product obtained during the synthesis of Arg-Glu-Asp-Val (REDV) with inhibitory activity in thrombin-activated platelet aggregation was carried out. The semipreparative column fractionation of REDV peptide was rechromatogra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14597d3add9aab3d17eb9977610cf245
https://doi.org/10.1016/0304-4165(91)90272-i

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Preparation of functionally active cell-permeable peptides by single-step ligation of two peptide modules

Autor: Lianshan Zhang, Sheila Timmons, James P. Tam, Troy R. Torgerson, Jacek Hawiger, Xue Yan Liu, Ann D. Colosia

Noninvasive cellular import of synthetic peptides can be accomplished by incorporating a hydrophobic, membrane-permeable sequence (MPS). Herein, we describe a facile method that expedites synthesis of biologically active, cell-permeable peptides by s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0393a3bb2c1716176a772d11836634b
https://europepmc.org/articles/PMC21313/

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Identification of a functionally important sequence in the cytoplasmic tail of integrin beta 3 by using cell-permeable peptide analogs

Autor: Jacek Hawiger, Yao-Zhong Lin, Sheila Timmons, Xue Yan Liu

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 93(21)

Integrins are major two-way signaling receptors responsible for the attachment of cells to the extracellular matrix and for cell-cell interactions that underlie immune responses, tumor metastasis, and progression of atherosclerosis and thrombosis. We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1976dce8d43e5f41e640f927d56a063
https://pubmed.ncbi.nlm.nih.gov/8876221

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