Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Sheila Nirenberg"'
Autor:
Boyuan Yan, Suresh Viswanathan, Scott E. Brodie, Wen-Tao Deng, Kirsten E. Coleman, William W. Hauswirth, Sheila Nirenberg
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 29, Iss , Pp 406-417 (2023)
Optogenetic gene therapies offer a promising strategy for restoring vision to patients with retinal degenerative diseases, such as retinitis pigmentosa (RP). Several clinical trials have begun in this area using different vectors and optogenetic prot
Externí odkaz:
https://doaj.org/article/7c6b4f3a22b54425a4e36725bb472ee2
Autor:
Boyuan Yan, Sheila Nirenberg
Publikováno v:
IEEE Journal of Translational Engineering in Health and Medicine, Vol 11, Pp 296-305 (2023)
Optogenetics is a new approach for controlling neural circuits with numerous applications in both basic and clinical science. In retinal degenerative diseases, the photoreceptors die, but inner retinal cells remain largely intact. By expressing light
Externí odkaz:
https://doaj.org/article/2a65c1ef992646e98c8a61f03ee36416
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e53363 (2013)
At every level of the visual system - from retina to cortex - information is encoded in the activity of large populations of cells. The populations are not uniform, but contain many different types of cells, each with its own sensitivities to visual
Externí odkaz:
https://doaj.org/article/d2c9b478fc324035aeb700ec4dc9da77
Autor:
Chethan Pandarinath, Illya Bomash, Jonathan D Victor, Glen T Prusky, Wayne Tschetter, Sheila Nirenberg
Publikováno v:
Frontiers in Computational Neuroscience, Vol 4 (2010)
An animal’s ability to rapidly adjust to new conditions is essential to its survival. The nervous system, then, must be built with the flexibility to adjust, or shift, its processing capabilities on the fly. To understand how this flexibility comes
Externí odkaz:
https://doaj.org/article/0daccf766dc44af086310c78b1a97f79
Publikováno v:
PLoS Computational Biology, Vol 5, Iss 5, p e1000380 (2009)
One of the most critical problems we face in the study of biological systems is building accurate statistical descriptions of them. This problem has been particularly challenging because biological systems typically contain large numbers of interacti
Externí odkaz:
https://doaj.org/article/e948b557e5944f76a9b2766c67842cba
Autor:
Karin Dedek, Chethan Pandarinath, Nazia M Alam, Kerstin Wellershaus, Timm Schubert, Klaus Willecke, Glen T Prusky, Reto Weiler, Sheila Nirenberg
Publikováno v:
PLoS ONE, Vol 3, Iss 3, p e1714 (2008)
BACKGROUND: The visual system can adjust itself to different visual environments. One of the most well known examples of this is the shift in spatial tuning that occurs in retinal ganglion cells with the change from night to day vision. This shift is
Externí odkaz:
https://doaj.org/article/bf1c389da91e4fc19cec3c588409547e
Autor:
Sheila Nirenberg
Publikováno v:
Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics.
Neuroscience research has focused largely on listening to the brain - on taking recordings, analyzing responses, and trying to extract meaning from them. But now we’re entering a new phase where we can go beyond listening and can start talking back
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9b22b9a8e12cabbe31c9e9b2b8978fd
https://doi.org/10.1117/12.2595079
https://doi.org/10.1117/12.2595079
Autor:
Sheila Nirenberg, Boyuan Yan
Publikováno v:
IEEE Transactions on Neural Systems and Rehabilitation Engineering. 26:233-243
Optogenetics offers a powerful new approach for controlling neural circuits. It has numerous applications in both basic and clinical science. These applications require stimulating devices with small processors that can perform real-time neural signa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11c10091cd45fe68a80bdf86a1cf231d
https://doi.org/10.1109/tnsre.2017.2763130
https://doi.org/10.1109/tnsre.2017.2763130
Publikováno v:
Vision Research. 121:57-71
Optogenetics methods are rapidly being developed as therapeutic tools for treating neurological diseases, in particular, retinal degenerative diseases. A critical component of the development is testing the safety of the light stimulation used to act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84e5f2a67acd4db2bacf6f36cf26c6c9
https://doi.org/10.1016/j.visres.2016.01.006
https://doi.org/10.1016/j.visres.2016.01.006
Autor:
Samuel G. Jacobson, Artur V. Cideciyan, Simone Pajaro, Alejandro J. Roman, Boyuan Yan, Sheila Nirenberg, Michele Pascolini, Jason Charng
Publikováno v:
Investigative Ophthalmology & Visual Science
PURPOSE To present stimuli with varied sizes, colors, and patterns over a large range of luminance. METHODS The filter bar used in scotopic MP1 was replaced with a custom slide-in tray that introduces light from an external projector driven by an add
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f1271deb03d2357a72f20d2aebc8aa2
https://pubmed.ncbi.nlm.nih.gov/27309625
https://pubmed.ncbi.nlm.nih.gov/27309625