Retinol and retinyl esters: biochemistry and physiology

Autor: Sheila M. O'Byrne, William S. Blaner

Publikováno v: Journal of Lipid Research, Vol 54, Iss 7, Pp 1731-1743 (2013)

By definition, a vitamin is a substance that must be obtained regularly from the diet. Vitamin A must be acquired from the diet, but unlike most vitamins, it can also be stored within the body in relatively high levels. For humans living in developed

Externí odkaz: https://doaj.org/article/37ef09b7bb714194b83062fca3e12e3a

Lipocalin 2, a Regulator of Retinoid Homeostasis and Retinoid-mediated Thermogenic Activation in Adipose Tissue

Autor: Hong Guo, William S. Blaner, Hongfeng Jiang, Jessica A. Deis, Xiaoli Chen, Rocio Foncea, Sheila M. O'Byrne, David A. Bernlohr, Yuanyuan Zhang

Publikováno v: Journal of Biological Chemistry. 291:11216-11229

We have recently characterized the role of lipocalin 2 (Lcn2) as a new adipose-derived cytokine in the regulation of adaptive thermogenesis via a non-adrenergic pathway. Herein, we explored a potential non-adrenergic mechanism by which Lcn2 regulates

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e12a05cf2ae60501beaf800e083ab72
https://doi.org/10.1074/jbc.m115.711556

Adipose-specific Lipoprotein Lipase Deficiency More Profoundly Affects Brown than White Fat Biology

Autor: Sheila M. O'Byrne, William S. Blaner, Manabu Takahashi, Konstantinos Drosatos, Yunying Hu, Ni Huiping Son, Ira J. Goldberg, Itsaso Garcia-Arcos, Yaeko Hiyama, Chuchun L. Chang, Richard J. Deckelbaum, Joseph C. Obunike, Kalyani G. Bharadwaj, Marit Westerterp, Hongfeng Jiang, Hiroaki Yagyu

Publikováno v: The Journal of Biological Chemistry, 288(20), 14046-14058. AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
Journal of biological chemistry, 288(20), 14046-14058. American Society for Biochemistry and Molecular Biology Inc.

Adipose fat storage is thought to require uptake of circulating triglyceride (TG)-derived fatty acids via lipoprotein lipase (LpL). To determine how LpL affects the biology of adipose tissue, we created adipose-specific LpL knock-out (ATLO) mice, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e28a31188ddf42ff821892409a23ea00
https://doi.org/10.1074/jbc.m113.469270

Multiple pathways ensure retinoid delivery to milk: studies in genetically modified mice

Autor: Ira J. Goldberg, William S. Blaner, Krzysztof Palczewski, Richard J. Deckelbaum, Sheila M. O'Byrne, Yuko Kako, Inge H Hansen

Publikováno v: American Journal of Physiology-Endocrinology and Metabolism. 298:E862-E870

Retinoids are absolutely required for normal growth and development during the postnatal period. We studied the delivery of retinoids to milk, availing of mouse models modified for proteins thought to be essential for this process. Milk retinyl ester

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a253349d70671679af69ad43bdd83bd9
https://doi.org/10.1152/ajpendo.00491.2009

Retinol-Binding Protein-Deficient Mice: Biochemical Basis for Impaired Vision

Autor: Sheila M. O'Byrne, William S. Blaner, Ira J. Goldberg, Yuko Kako, Roseann Piantedosi, Loredana Quadro, Silke Vogel, Max E. Gottesman

Publikováno v: Biochemistry. 41:15360-15368

We reported previously that mice lacking plasma retinol-binding protein (RBP) are phenotypically normal except that they display impaired vision at the time of weaning. This visual defect is associated with greatly diminished eyecup levels of retinal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad0190db0eca2b0e6b846b5875e668b2
https://doi.org/10.1021/bi0268551