Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Sheila M. Healy"'
Autor:
Xuefei Cao, Rui Xiong, Qiangen Wu, Hans Rosenfeldt, Levan Muskhelishvili, Ying Chen, Matthew Bryant, Sheila M Healy, Tao Chen, Yue Wu, Leihong Wu
Publikováno v:
Archives of Toxicology. 95:1763-1778
Exposure to cigarette smoke (CS) is strongly associated with impaired mucociliary clearance (MCC), which has been implicated in the pathogenesis of CS-induced respiratory diseases, such as chronic obstructive pulmonary diseases (COPD). In this study,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a93777db26e5ae7e7b6aae639935bc5
https://doi.org/10.1007/s00204-021-03016-0
https://doi.org/10.1007/s00204-021-03016-0
Autor:
Rui Xiong, Levan Muskhelishvili, Tao Chen, Yue Wu, Qiangen Wu, Xuefei Cao, Priya Tripathi, Hans Rosenfeldt, Kelly Davis, Matthew Bryant, Sheila M Healy, Ying Chen
Publikováno v:
Archives of Toxicology
Exposure to cigarette smoke (CS) is a known risk factor in the pathogenesis of smoking-caused diseases, such as chronic obstructive pulmonary diseases (COPD) and lung cancer. To assess the effects of CS on the function and phenotype of airway epithel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bb66957f0da802fc8331573af7bb510
https://doi.org/10.1007/s00204-021-03008-0
https://doi.org/10.1007/s00204-021-03008-0
Publikováno v:
Environmental toxicology and pharmacology. 83
Establishing accurate dosimetry is important for assessing the toxicity of xenobiotics as well as for comparing responses between different test systems. In this study, we used acrolein as a model toxicant and defined the concentration-response relat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdbe74d278b4c302f8377b61bc73acff
https://pubmed.ncbi.nlm.nih.gov/33385576
https://pubmed.ncbi.nlm.nih.gov/33385576
Autor:
Matthew Savidge, Mamata De, Luis G. Valerio, Pei-Hsuan Hung, Jueichuan Connie Kang, Sheila M Healy
Publikováno v:
Journal of applied toxicology : JATREFERENCES. 40(11)
Electronic nicotine delivery systems (ENDS) are regulated tobacco products and often contain flavor compounds. Given the concern of increased use and the appeal of ENDS by young people, evaluating the potential of flavors to induce DNA damage is impo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a86b65b973de9a1d62b8dce724e7244
https://pubmed.ncbi.nlm.nih.gov/32662109
https://pubmed.ncbi.nlm.nih.gov/32662109
Autor:
Rui Xiong, Xuefei Cao, Jennifer M Shemansky, Qiangen Wu, Levan Muskhelishvili, Kelly Davis, Matthew Bryant, Hans Rosenfeldt, Sheila M Healy
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 166(2)
Acrolein is a reactive unsaturated aldehyde and is found at high concentrations in both mainstream and side-stream tobacco smoke. Exposure to acrolein via cigarette smoking has been associated with acute lung injury, chronic obstructive pulmonary dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31d1d4d0691539c7959f671a204c9c3f
https://pubmed.ncbi.nlm.nih.gov/30204913
https://pubmed.ncbi.nlm.nih.gov/30204913
Publikováno v:
Chemical Research in Toxicology. 13:1181-1186
The formation of monomethylarsonous acid (MMA(III)) by tissue homogenates of brain, bladder, spleen, liver, lung, heart, skin, kidney, or testis of male Golden Syrian hamsters was assessed using [(14)C]monomethylarsonic acid (MMA(V)) as the substrate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afaea277560cdec8561ac393beaf05be
https://doi.org/10.1021/tx000154s
https://doi.org/10.1021/tx000154s
Autor:
H. Vasken Aposhian, Gerald F. O'Malley, R M Maiorino, Mingsheng Ma, Richard C. Dart, Wayne A. Van Voorhies, Robert A. Zakharyan, Luke Yip, William R. Cullen, Paul Andrewes, Baoshan Zheng, Allison Titcomb, Mariano E. Cebrián, Sheila M. Healy, Mary M. Aposhian, X. Chris Le, Zhai Cheng
Publikováno v:
Toxicology and Applied Pharmacology. 165:74-83
The administration of sodium 2,3-dimercapto-1-propane sulfonate (DMPS) to humans chronically exposed to inorganic arsenic in their drinking water resulted in the increased urinary excretion of arsenic, the appearance and identification of monomethyla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af4e866979713aac896402c372c81e46
https://doi.org/10.1006/taap.2000.8922
https://doi.org/10.1006/taap.2000.8922
Autor:
Philip G. Board, Mary M. Aposhian, Jay S. Petrick, Robert A. Zakharyan, Eric Wildfang, Dean E. Carter, Adriana Sampayo-Reyes, H. Vasken Aposhian, D.N. Guha Mazumder, Sheila M. Healy
Publisher Summary The biotransformation of inorganic arsenate to dimethylarsinic acid (DMA) involves a series of enzymatic steps. Recent studies based on amino acid homology and other properties demonstrate that the human liver arsenate reductase and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::188ca203d0c1f868d5239626c1137ea6
https://doi.org/10.1016/b978-044451441-7/50018-x
https://doi.org/10.1016/b978-044451441-7/50018-x
Autor:
Adriana Sampayo-Reyes, Philip G. Board, H V Aposhian, Daniel C. Liebler, George Tsaprailis, Robert A. Zakharyan, Sheila M. Healy
Publikováno v:
Chemical research in toxicology. 14(8)
The drinking of water containing large amounts of inorganic arsenic is a worldwide major public health problem because of arsenic carcinogenicity. Yet an understanding of the specific mechanism(s) of inorganic arsenic toxicity has been elusive. We ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77cec3b59728a55e82a4cefc71bb6da8
https://pubmed.ncbi.nlm.nih.gov/11511179
https://pubmed.ncbi.nlm.nih.gov/11511179
Autor:
Mary M. Aposhian, Jürgen Gailer, Timothy R. Radabaugh, LaTanya A. Powell, Sheila M. Healy, Gregory M. Bogdan, Robert A. Zakharyan, H. Vasken Aposhian, Eric Wildfang
Publisher Summary Arsenate is reduced to arsenite enzymatically by arsenate reductase and nonenzymatically by GSH. An early step in the detoxification appears to be the formation of the Gailer compound, seleno-bis(S-glutathionyl) arsinium ion, which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9069112afb38f7ac4a934539ce7e153b
https://doi.org/10.1016/b978-008043648-7/50033-9
https://doi.org/10.1016/b978-008043648-7/50033-9