Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Sheila M. Cohen"'
Autor:
Victor D.-H. Ding, Gregory J. Kaczorowski, Michael Wright, Sheila M. Cohen, Emma R. Parmee, Jeffrey G. Werrmann, Corin O. Miller, Brian A. Kirk, Laurie Tota, Mari R. Candelore, Bei B. Zhang, Joseph L. Duffy, James R. Tata
Publikováno v:
Bioorganic & Medicinal Chemistry. 14:1506-1517
The demonstration of pharmacodynamic efficacy of novel chemical entities represents a formidable challenge in the early exploration of synthetic lead classes. Here, we demonstrate a technique to validate the biological efficacy of novel antagonists o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ad8dd0dd3883a9ac8c23c3df50963e1
https://doi.org/10.1016/j.bmc.2005.10.008
https://doi.org/10.1016/j.bmc.2005.10.008
Autor:
Kevin T. Chapman, Corin O. Miller, Guoqiang Jiang, Victor D.-H. Ding, Joseph L. Duffy, Ed Brady, Sheila M. Cohen, Xiaodong Yang, Richard Saperstein, Mari R. Candelore, Sajjad A. Qureshi, Zhihua Li, James R. Tata, Dan Xie, Laurie Tota, Alka Bansal, David E. Moller, Bei B. Zhang
Publikováno v:
Diabetes. 53:3267-3273
Glucagon maintains glucose homeostasis during the fasting state by promoting hepatic gluconeogenesis and glycogenolysis. Hyperglucagonemia and/or an elevated glucagon-to-insulin ratio have been reported in diabetic patients and animals. Antagonizing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f2904b3cc0b8f7628ee293dc5b39057
https://doi.org/10.2337/diabetes.53.12.3267
https://doi.org/10.2337/diabetes.53.12.3267
Publikováno v:
Proceedings of the National Academy of Sciences. 95:7385-7390
The recent discovery of leptin receptors in peripheral tissue raises questions about which of leptin’s biological actions arise from direct effects of the hormone on extraneural tissues and what intracellular mechanisms are responsible for leptin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22b6d162b2daaf8a0003245cddc2e5d6
https://doi.org/10.1073/pnas.95.13.7385
https://doi.org/10.1073/pnas.95.13.7385
Autor:
Jeffrey G. Werrmann, Sheila M. Cohen
Publikováno v:
Journal of Cardiovascular Pharmacology. 27:177-182
To assess the role of angiotensin II (AII) in the development of myocardial dysfunction during ischemia and reperfusion, the effects of either oral pretreatment with 1 mg/kg losartan or treatment with 4.5 mu M losartan in vitro were compared with eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a603dd818ba0f64f1f4c0cde3bd03890
https://doi.org/10.1097/00005344-199602000-00001
https://doi.org/10.1097/00005344-199602000-00001
Autor:
Sheila M. Cohen, G Harris, J G Jacobs, W K Tanaka, Gary H. Rasmusson, T M Nett, Jeffrey G. Werrmann, P. F. Malatesta, Srinivasa Prahalada
Publikováno v:
The Prostate. 26:55-71
Four new azasteroid inhibitors of steroid 5 alpha-reductase were compared to the benchmark compound finasteride, each at a dose level of 1 mg/kg/day, as well to placebo and to castration, in seven groups of mature male beagle dogs with enlarged prost
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe170e9ccd86ec874e441fdeaa76c7ec
https://doi.org/10.1002/pros.2990260202
https://doi.org/10.1002/pros.2990260202
Publikováno v:
Magnetic Resonance in Medicine. 32:556-564
The triple quantum filtered 23Na NMR method is applied here to measure the effects of EIPA, a specific inhibitor of the Na+/H+ antiporter, on relative intracellular sodium concentrations in isolated working hearts at baseline, during ischemia, and at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::106ebac1e8a1a5a0754cbf992204d2cf
https://doi.org/10.1002/mrm.1910320503
https://doi.org/10.1002/mrm.1910320503
Autor:
Sheila M. Cohen, Jeffrey G. Werrmann
Publikováno v:
Journal of Cardiovascular Pharmacology. 24:573-586
To assess the role of angiotensin II (AII) in development of myocardial injury during ischemia and reperfusion, the effects of short-term treatment with the angiotensin-converting enzyme (ACE) inhibitor lisinopril were compared with the effects of sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8b58544f427dd2236c5e490e52b1355
https://doi.org/10.1097/00005344-199410000-00008
https://doi.org/10.1097/00005344-199410000-00008
Autor:
J. Shpungin, P. F. Malatesta, S. Prahalada, Robert 'Nick' Bryan, Jeffrey G. Werrmann, Katherine H. Taber, E. H. Cordes, Sheila M. Cohen, C. Berman, J. R. Carlin
Publikováno v:
Magnetic Resonance in Medicine. 21:55-70
A leading role for prostatic levels of dihydrotestosterone (DHT) in the pathogenesis of benign prostatic hyperplasia is well established, if incompletely understood. The present study provides initial confirmation that 5α-reductase inhibition alone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64fcb407e64d0c553a499b7f14eeb541
https://doi.org/10.1002/mrm.1910210109
https://doi.org/10.1002/mrm.1910210109
Publikováno v:
Journal of Magnetic Resonance (1969). 19:385-392
In order to interpret adequately any temperature dependence measurements of NMR shifts it is necessary to have an independent measurement of the temperature dependence of the chemical shielding of the reference substance itself. Such data have previo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e07cdb69caeac5ccf99a5aeca02c3025
https://doi.org/10.1016/0022-2364(75)90054-2
https://doi.org/10.1016/0022-2364(75)90054-2
Publikováno v:
The Journal of Chemical Physics. 65:3401-3406
129Xe chemical shifts in mixtures of Xe with CH4, CF4, and SiF4 as a function of temperature and density have been obtained by pulsed Fourier transform NMR spectroscopy. The low densities of gases used and the previously determined 129Xe shifts in pu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4d2da7528797160351bf4882cf31e7b
https://doi.org/10.1063/1.433592
https://doi.org/10.1063/1.433592