Zobrazeno 1 - 10
of 234
pro vyhledávání: '"Sheila M Keating"'
Autor:
Carlos Henrique Valente Moreira, Ana Luiza Bierrenbach, Cesar Augusto Taconeli, Léa Campos de Oliveira-da Silva, Lewis F. Buss, Sheila M. Keating, Erika Regina Manuli, Noemia Barbosa Carvalho, Cristina Guastini, Sonia Bakkour Coco, José Ângelo Lauletta Lindoso, Lucas Augusto Moyses Franco, Fabio Ghilardi, Flavia Cristina da Silva Sales, Paul Contestable, Clara Di Germanio, Michael P. Busch, Ester Cerdeira Sabino
Publikováno v:
Frontiers in Parasitology, Vol 2 (2023)
BackgroundEvaluating the effectiveness of Chagas disease treatment poses challenges due to the lack of biomarkers for disease progression and therapeutic response. In this study, we aimed to assess the clearance of Trypanosoma cruzi (T. cruzi) parasi
Externí odkaz:
https://doaj.org/article/19467739d4de4adabd545ddc795345f3
Autor:
Rena A. Mizrahi, Wendy Y. Lin, Ashley Gras, Ariel R. Niedecken, Ellen K. Wagner, Sheila M. Keating, Nikita Ikon, Vishal A. Manickam, Michael A. Asensio, Jackson Leong, Angelica V. Medina-Cucurella, Emily Benzie, Kyle P. Carter, Yao Chiang, Robert C. Edgar, Renee Leong, Yoong Wearn Lim, Jan Fredrik Simons, Matthew J. Spindler, Kacy Stadtmiller, Nicholas Wayham, Dirk Büscher, Jose Vicente Terencio, Clara Di Germanio, Steven M. Chamow, Charles Olson, Paula A. Pino, Jun-Gyu Park, Amberlee Hicks, Chengjin Ye, Andreu Garcia-Vilanova, Luis Martinez-Sobrido, Jordi B. Torrelles, David S. Johnson, Adam S. Adler
Publikováno v:
Pathogens, Vol 11, Iss 7, p 806 (2022)
Conventionally, hyperimmune globulin drugs manufactured from pooled immunoglobulins from vaccinated or convalescent donors have been used in treating infections where no treatment is available. This is especially important where multi-epitope neutral
Externí odkaz:
https://doaj.org/article/30fbcf61da8b46ddab93ba7e247ee57f
Autor:
Magnus Gisslen, Sheila M Keating, Serena Spudich, Victor Arechiga, Sophie Stephenson, Henrik Zetterberg, Clara Di Germanio, Kaj Blennow, Dietmar Fuchs, Lars Hagberg, Philip J Norris, Julia Peterson, Barbara L Shacklett, Constantin T Yiannoutsos, Richard W Price
Publikováno v:
PLoS ONE, Vol 16, Iss 5, p e0250987 (2021)
ObjectiveTo characterize the evolution of central nervous system (CNS) inflammation in HIV-1 infection applying a panel of cerebrospinal fluid (CSF) inflammatory biomarkers to grouped subjects representing a broad spectrum of systemic HIV-1 immune su
Externí odkaz:
https://doaj.org/article/2ec0545adb214b17b48bc2f6ac37006b
Autor:
Leah H. Rubin, Yanxun Xu, Philip J. Norris, Xuzhi Wang, Raha Dastgheyb, Kathryn C. Fitzgerald, Sheila M. Keating, Robert C. Kaplan, Pauline M. Maki, Kathryn Anastos, Gayle Springer, Lorie Benning, Seble Kassaye, Deborah R. Gustafson, Victor G. Valcour, Dionna W. Williams
Publikováno v:
Frontiers in Integrative Neuroscience, Vol 14 (2020)
Immunologic function is an important determinant of cognition. Here we examined the contribution of early immune signatures to cognitive performance among HIV-infected, virally suppressed women (HIV+VS) and in HIV-uninfected (HIV-) women. Specificall
Externí odkaz:
https://doaj.org/article/c13ac68db9f84613a6b15aaeb40fa818
Autor:
Shannon Kelly, Evan S Jacobs, Mars Stone, Sheila M Keating, Tzong-Hae Lee, Daniel Chafets, John Heitman, Melanie Dimapasoc, Eva Operskalski, Ward Hagar, Elliott Vichinsky, Michael P Busch, Philip J Norris, Brian Custer, Recipient Epidemiology and Donor Evaluation Study (REDS-III)
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0218880 (2020)
People with sickle cell disease (SCD) are reported to have low rates of HIV infection, slower progression to AIDS and lower HIV-associated mortality compared to the general population. Mechanisms of potential resistance to HIV in SCD are incompletely
Externí odkaz:
https://doaj.org/article/cf2e5f2095cc40c79070e2ba6fcd672f
Autor:
Nicholas P Wayham, Ariel R Niedecken, Jan Fredrik Simons, Yao Y Chiang, Angélica V Medina-Cucurella, Rena A Mizrahi, Ellen K Wagner, Ashley Gras, Ilana Segal, Peyton Witte, Alexis Enstrom, Aristea Bountouvas, Sabrina M Nelson, Tess Weinberger, David Tan, Michael A Asensio, Alagu Subramanian, Yoong Wearn Lim, Adam S Adler, Sheila M Keating
Publikováno v:
The Journal of Infectious Diseases.
Emerging variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) possess mutations that prevent antibody therapeutics from maintaining antiviral binding and neutralizing efficacy. Monoclonal antibodies (mAbs) shown to neutralize Wuha
Autor:
Adam R, Ward, Allison S, Thomas, Eva M, Stevenson, Szu-Han, Huang, Sheila M, Keating, Rajesh T, Gandhi, Deborah K, McMahon, Ronald J, Bosch, Bernard J, Macatangay, Joshua C, Cyktor, Joseph J, Eron, John W, Mellors, R Brad, Jones
Publikováno v:
AIDS. 36:1617-1628
People with HIV (PWH) have persistently elevated levels of inflammation and immune activation despite suppressive antiretroviral therapy (ART), with specific biomarkers showing associations with non-AIDS-defining morbidities and mortality. We investi
Autor:
Daniel I S Rosenbloom, Peter Bacchetti, Mars Stone, Xutao Deng, Ronald J Bosch, Douglas D Richman, Janet D Siliciano, John W Mellors, Steven G Deeks, Roger G Ptak, Rebecca Hoh, Sheila M Keating, Melanie Dimapasoc, Marta Massanella, Jun Lai, Michele D Sobolewski, Deanna A Kulpa, Michael P Busch, Reservoir Assay Validation and Evaluation Network (RAVEN) Study Group
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 4, p e1006849 (2019)
Quantitative viral outgrowth assays (QVOA) use limiting dilutions of CD4+ T cells to measure the size of the latent HIV-1 reservoir, a major obstacle to curing HIV-1. Efforts to reduce the reservoir require assays that can reliably quantify its size
Externí odkaz:
https://doaj.org/article/b5955aac1a054bdaae557617f2bee089
Autor:
Sheila M Keating, Wes Rountree, Eduard Grebe, Andrea L Pappas, Mars Stone, Dylan Hampton, Christopher A Todd, Marek S Poniewierski, Ana Sanchez, Cassandra G Porth, Thomas N Denny, Michael P Busch, EQAPOL Limiting Antigen (LAg) Incidence Assay External Quality Assurance (EQA) Program
Publikováno v:
PLoS ONE, Vol 14, Iss 9, p e0222290 (2019)
Laboratory assays for identifying recent HIV-1 infections are widely used for estimating incidence in cross-sectional population-level surveys in global HIV-1surveillance. Adequate assay and laboratory performance are required to ensure accurate inci
Externí odkaz:
https://doaj.org/article/d55a41e9565d4576b93b4d0c95f00e09
Autor:
Joseph B Sempa, Alex Welte, Michael P Busch, Jake Hall, Dylan Hampton, Shelley N Facente, Sheila M Keating, Kara Marson, Neil Parkin, Christopher D Pilcher, Gary Murphy, Eduard Grebe, Consortium for the Evaluation and Performance of HIV Incidence Assays (CEPHIA)
Publikováno v:
PLoS ONE, Vol 14, Iss 7, p e0220345 (2019)
BackgroundTwo manufacturers, Maxim Biomedical and Sedia Biosciences Corporation, supply CDC-approved versions of the HIV-1 Limiting Antigen Avidity EIA (LAg) for detecting 'recent' HIV infection in cross-sectional incidence estimation. This study ass
Externí odkaz:
https://doaj.org/article/d84c3385c34e4c6ca1a449a372057bd7