Zobrazeno 1 - 10
of 316
pro vyhledávání: '"Sheila K, Singh"'
Autor:
Kevin Wyszatko, Nancy Janzen, Luis Rafael Silva, Luke Kwon, Teesha Komal, Manuela Ventura, Chitra Venugopal, Sheila K. Singh, John F. Valliant, Saman Sadeghi
Publikováno v:
EJNMMI Research, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Background Cancer stem cells play an important role in driving tumor growth and treatment resistance, which makes them a promising therapeutic target to prevent cancer recurrence. Emerging cancer stem cell-targeted therapies would benefit fr
Externí odkaz:
https://doaj.org/article/492baa18e4e34a2ca48ac359ab64cdc4
Autor:
David Bakhshinyan, Yujin Suk, Laura Kuhlmann, Ashley A. Adile, Vladimir Ignatchenko, Stefan Custers, William D. Gwynne, Andrew Macklin, Chitra Venugopal, Thomas Kislinger, Sheila K. Singh
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-14 (2023)
Abstract Medulloblastoma (MB) is the most common type of malignant pediatric brain cancer. The current standard of care (SOC) involves maximal safe resection and chemoradiotherapy in individuals older than 3 years, often leading to devastating neuroc
Externí odkaz:
https://doaj.org/article/4d03f9f8846c4b28a993fd246a4af2b1
Autor:
Emma Martell, Helgi Kuzmychova, Harshal Senthil, Esha Kaul, Chirayu R. Chokshi, Chitra Venugopal, Christopher M. Anderson, Sheila K. Singh, Tanveer Sharif
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-20 (2023)
Abstract Despite tremendous research efforts, successful targeting of aberrant tumor metabolism in clinical practice has remained elusive. Tumor heterogeneity and plasticity may play a role in the clinical failure of metabolism-targeting intervention
Externí odkaz:
https://doaj.org/article/6a8d4e7ad8b24e438bb93abf59e42c2c
Autor:
Emma Martell, Helgi Kuzmychova, Esha Kaul, Harshal Senthil, Subir Roy Chowdhury, Ludivine Coudière Morrison, Agnes Fresnoza, Jamie Zagozewski, Chitra Venugopal, Chris M. Anderson, Sheila K. Singh, Versha Banerji, Tamra E. Werbowetski-Ogilvie, Tanveer Sharif
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-26 (2023)
Abstract Group 3 medulloblastoma (G3 MB) carries the worst prognosis of all MB subgroups. MYC oncoprotein is elevated in G3 MB tumors; however, the mechanisms that support MYC abundance remain unclear. Using metabolic and mechanistic profiling, we pi
Externí odkaz:
https://doaj.org/article/5c5a7943a1a04bfc88a6392559029355
Autor:
Jeremy K. Chan, William D. Gwynne, Brandon Y. Lieng, Andrew T. Quaile, Chitra Venugopal, Sheila K. Singh, J. Rafael Montenegro-Burke
Publikováno v:
STAR Protocols, Vol 4, Iss 4, Pp 102736- (2023)
Summary: Liquid chromatography-mass spectrometry (LC-MS)-based metabolomics and lipidomics have recently been used to show that MYC-amplified group 3 medulloblastoma tumors are driven by metabolic reprogramming. Here, we present a protocol to extract
Externí odkaz:
https://doaj.org/article/55d757e604f842cdb3471f89c9648dbf
Autor:
Jonathan L Bramson, Arya Afsahi, Allyson E Moore, Nickolas Serniuck, Hayley Nault, Sheila K Singh
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/3ab92fea536844a5a30f896fdeb34c0d
Autor:
Michelle M. Kameda-Smith, Helen Zhu, En-Ching Luo, Yujin Suk, Agata Xella, Brian Yee, Chirayu Chokshi, Sansi Xing, Frederick Tan, Raymond G. Fox, Ashley A. Adile, David Bakhshinyan, Kevin Brown, William D. Gwynne, Minomi Subapanditha, Petar Miletic, Daniel Picard, Ian Burns, Jason Moffat, Kamil Paruch, Adam Fleming, Kristin Hope, John P. Provias, Marc Remke, Yu Lu, Tannishtha Reya, Chitra Venugopal, Jüri Reimand, Robert J. Wechsler-Reya, Gene W. Yeo, Sheila K. Singh
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
MYC amplification is an independent prognostic factor for the most aggressive subgroup (Group 3) of pediatric medulloblastoma (G3 MB). Here, the authors highlight the role of the RNA-binding protein, Musashi-1 (MSI1) in G3 MB and identify MSI1-bound
Externí odkaz:
https://doaj.org/article/3eace71e4f774decb598d79c690ed3aa
Autor:
David Bakhshinyan, Yujin Suk, Laura Kuhlmann, Ashley A. Adile, Vladimir Ignatchenko, Stefan Custers, William D. Gwynne, Andrew Macklin, Chitra Venugopal, Thomas Kislinger, Sheila K. Singh
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/a8f03f8fe12c41f0a4d7d6925b44dd42
Publikováno v:
STAR Protocols, Vol 3, Iss 3, Pp 101628- (2022)
Summary: Human neural stem cells (hNSCs) are a valuable tool in brain cancer research since they are used as a normal control for multiple assays, mainly pertaining to toxicity. Here, we present a protocol to safely and successfully derive and cultur
Externí odkaz:
https://doaj.org/article/2777d6ce58714b06b642178c4b97da57
Autor:
Nazanin Tatari, Xiaoyu Zhang, Shawn C. Chafe, Dillon McKenna, Keith A. Lawson, Minomi Subapanditha, Muhammad Vaseem Shaikh, Mathieu Seyfrid, Neil Savage, Chitra Venugopal, Jason Moffat, Sheila K. Singh
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Glioblastomas (GBM), the most common malignant primary adult brain tumors, are uniformly lethal and are in need of improved therapeutic modalities. GBM contain extensive regions of hypoxia and are enriched in therapy resistant brain tumor-initiating
Externí odkaz:
https://doaj.org/article/0954f30be233489fa8bd62d8a5099f88