Zobrazeno 1 - 10
of 209
pro vyhledávání: '"Sheila E Francis"'
Autor:
Osman Shabir, Ben Pendry, Llywelyn Lee, Beth Eyre, Paul S Sharp, Monica A Rebollar, David Drew, Clare Howarth, Paul R Heath, Stephen B Wharton, Sheila E Francis, Jason Berwick
Publikováno v:
eLife, Vol 11 (2022)
Neurovascular coupling is a critical brain mechanism whereby changes to blood flow accompany localised neural activity. The breakdown of neurovascular coupling is linked to the development and progression of several neurological conditions including
Externí odkaz:
https://doaj.org/article/92e57f89b041496cb62439a786902073
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88388 (2014)
Even within accepted normal ranges, higher serum phosphorus, dietary phosphorus density, parathyroid hormone (PTH) and alkaline phosphatase (ALP) are independent predictors of cardiovascular mortality. Lower serum 25-hydroxy vitamin D (25(OH)D) also
Externí odkaz:
https://doaj.org/article/b37fbc833f86475a97fe3651187dc372
Autor:
Timothy Ellam, Abdul Hameed, Risat ul Haque, Munitta Muthana, Martin Wilkie, Sheila E Francis, Timothy J A Chico
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88767 (2014)
Observational data associate lower levels of serum vitamin D with coronary artery calcification, cardiovascular events and mortality. However, there is little interventional evidence demonstrating that moderate vitamin D deficiency plays a causative
Externí odkaz:
https://doaj.org/article/489f00540e5c451b8993696294a224db
Autor:
Abdul Hameed, Ellen Bennett, Barbara Ciani, Loes P C Hoebers, Roy Milner, Allan Lawrie, Sheila E Francis, Andrew J Grierson
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54636 (2013)
A KIF6 variant in man has been reported to be associated with adverse cardiovascular outcomes after myocardial infarction. No clear biological or physiological data exist for Kif6. We sought to investigate the impact of a deleterious KIF6 mutation on
Externí odkaz:
https://doaj.org/article/6c4a52149e6a465cb745ebea6b1b474c
Autor:
Martin A Bewley, Helen M Marriott, Calogero Tulone, Sheila E Francis, Timothy J Mitchell, Robert C Read, Benny Chain, Guido Kroemer, Moira K B Whyte, David H Dockrell
Publikováno v:
PLoS Pathogens, Vol 7, Iss 1, p e1001262 (2011)
The bactericidal function of macrophages against pneumococci is enhanced by their apoptotic demise, which is controlled by the anti-apoptotic protein Mcl-1. Here, we show that lysosomal membrane permeabilization (LMP) and cytosolic translocation of a
Externí odkaz:
https://doaj.org/article/098ec9f941f241339c263c49479fd2ad
Autor:
Lynne R. Prince, Sheila E. Francis
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 7 (2023)
Externí odkaz:
https://doaj.org/article/42d9aac8b92749eda9d91087db1c86ca
Autor:
Rohit Bazaz, Helen M. Marriott, Carl Wright, Janet Chamberlain, Laura E. West, Catherine Gelsthorpe, Paul R. Heath, Afsaneh Maleki-Dizaji, Sheila E. Francis, David H. Dockrell
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
IntroductionDespite epidemiological associations between community acquired pneumonia (CAP) and myocardial infarction, mechanisms that modify cardiovascular disease during CAP are not well defined. In particular, largely due to a lack of relevant exp
Externí odkaz:
https://doaj.org/article/6665aae7966b4665af002be385a30c39
Autor:
Sheila E. Francis, Charlotte K. Moore, Victoria J. Cookson, Diane V. Lefley, Russell Hughes, Paul R. Heath, Catherine A. Evans, Amy R. Spicer-Hadlington, Khawla Ahmed, A. Graham Pockley, Jayakumar Vadakekolathu, Ana E. Amariutei, Penelope D. Ottewell, Emmanuel Pinteaux, Lewis A. Quayle, Claudia Tulotta
Publikováno v:
npj Breast Cancer, Vol 7, Iss 1, Pp 1-15 (2021)
NPJ Breast Cancer
npj Breast Cancer
NPJ Breast Cancer
npj Breast Cancer
Breast cancer bone metastasis is currently incurable, ~75% of patients with late-stage breast cancer develop disease recurrence in bone and available treatments are only palliative. We have previously shown that production of the pro-inflammatory cyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aee4edcf7cfd90ae70dfe6caa0dfa98a
https://doaj.org/article/db7c85c82ea947e69d237a3402f52c96
https://doaj.org/article/db7c85c82ea947e69d237a3402f52c96
Autor:
Laura Martinez-Campesino, Klaudia Kocsy, Jaime Cañedo, Jessica M. Johnston, Charlotte E. Moss, Simon A. Johnston, Stephen Hamby, Alison H. Goodall, Jessica Redgrave, Sheila E. Francis, Endre Kiss-Toth, Heather L. Wilson
Publikováno v:
Frontiers in Cardiovascular Medicine. 9
Tribbles 3 (TRIB3) modulates lipid and glucose metabolism, macrophage lipid uptake, with a gain-of-function variant associated with increased cardiovascular risk. Here we set out to examine the role of this pseudokinase in atherosclerotic plaque deve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83c09bb09e6fac3b127e1f0179c02d1b
https://doi.org/10.3389/fcvm.2022.948461
https://doi.org/10.3389/fcvm.2022.948461
Autor:
Neil E. Humphreys, Werner Müller, Emmanuel Pinteaux, Ari Waisman, Ilgiz A. Mufazalov, Wesam H. Abdulaal, Sheila E. Francis, Maj Simonsen-Jackson
Publikováno v:
Pinteaux, E, Abdulaal, W H, Mufazalov, I A, Humphreys, N E, Simonsen-Jackson, M, Francis, S, Müller, W & Waisman, A 2020, ' Cell-specific conditional deletion of interleukin-1 (IL-1) ligands and its receptors: a new toolbox to study the role of IL-1 in health and disease ', Journal of Molecular Medicine, vol. 98, no. 7, pp. 923-930 . https://doi.org/10.1007/s00109-020-01928-5
Journal of Molecular Medicine (Berlin, Germany)
Journal of Molecular Medicine (Berlin, Germany)
The pro-inflammatory cytokine interleukin-1 (IL-1) plays a key role in many physiological processes and during the inflammatory and immune response to most common diseases. IL-1 exists as two agonists, IL-1α and IL-1β that bind to the only signalin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6042ca4d4530543f05776ee329707ecd
https://doi.org/10.1007/s00109-020-01928-5
https://doi.org/10.1007/s00109-020-01928-5