Zobrazeno 1 - 10
of 244
pro vyhledávání: '"Sheila E Francis"'
Autor:
Lynne R. Prince, Sheila E. Francis
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 7 (2023)
Externí odkaz:
https://doaj.org/article/42d9aac8b92749eda9d91087db1c86ca
Autor:
Rohit Bazaz, Helen M. Marriott, Carl Wright, Janet Chamberlain, Laura E. West, Catherine Gelsthorpe, Paul R. Heath, Afsaneh Maleki-Dizaji, Sheila E. Francis, David H. Dockrell
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
IntroductionDespite epidemiological associations between community acquired pneumonia (CAP) and myocardial infarction, mechanisms that modify cardiovascular disease during CAP are not well defined. In particular, largely due to a lack of relevant exp
Externí odkaz:
https://doaj.org/article/6665aae7966b4665af002be385a30c39
Autor:
Laura Martinez-Campesino, Klaudia Kocsy, Jaime Cañedo, Jessica M. Johnston, Charlotte E. Moss, Simon A. Johnston, Stephen Hamby, Alison H. Goodall, Jessica Redgrave, Sheila E. Francis, Endre Kiss-Toth, Heather L. Wilson
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Tribbles 3 (TRIB3) modulates lipid and glucose metabolism, macrophage lipid uptake, with a gain-of-function variant associated with increased cardiovascular risk. Here we set out to examine the role of this pseudokinase in atherosclerotic plaque deve
Externí odkaz:
https://doaj.org/article/1df53f81336a40e38b43f7c0fbff1e15
Autor:
Osman Shabir, Ben Pendry, Llywelyn Lee, Beth Eyre, Paul S Sharp, Monica A Rebollar, David Drew, Clare Howarth, Paul R Heath, Stephen B Wharton, Sheila E Francis, Jason Berwick
Publikováno v:
eLife, Vol 11 (2022)
Neurovascular coupling is a critical brain mechanism whereby changes to blood flow accompany localised neural activity. The breakdown of neurovascular coupling is linked to the development and progression of several neurological conditions including
Externí odkaz:
https://doaj.org/article/92e57f89b041496cb62439a786902073
Autor:
Nadine D. Arnold, Josephine A. Pickworth, Laura E. West, Sarah Dawson, Joana A. Carvalho, Helen Casbolt, Adam T. Braithwaite, James Iremonger, Lewis Renshall, Volker Germaschewski, Matthew McCourt, Philip Bland-Ward, Hager Kowash, Abdul G. Hameed, Alexander M. K. Rothman, Maria G. Frid, A. A. Roger Thompson, Holly R. Evans, Mark Southwood, Nicholas W. Morrell, David C. Crossman, Moira K. B. Whyte, Kurt R. Stenmark, Christopher M. Newman, David G. Kiely, Sheila E. Francis, Allan Lawrie
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
Pulmonary arterial hypertension (PAH) is characterised by progressive pulmonary vascular remodelling. Here, Arnold et al. develop a therapeutic antibody targeting osteoprotegerin and find it attenuates pulmonary vascular remodelling in multiple roden
Externí odkaz:
https://doaj.org/article/fbbe9cf6fb44471db21ebf04ce2094b6
Publikováno v:
BMC Neuroscience, Vol 19, Iss 1, Pp 1-16 (2018)
Abstract Efficient blood supply to the brain is of paramount importance to its normal functioning and improper blood flow can result in potentially devastating neurological consequences. Cerebral blood flow in response to neural activity is intrinsic
Externí odkaz:
https://doaj.org/article/f96857803dbe4e9fa2e62ce38d65eefe
Autor:
Sarah A. Smith, PhD, Andriy O. Samokhin, PhD, Mabruka Alfadi, PhD, Emer C. Murphy, PhD, David Rhodes, MSc, W. Mike L. Holcombe, PhD, Endre Kiss-Toth, PhD, Robert F. Storey, BSc, BM, DM, Siu-Pok Yee, PhD, Sheila E. Francis, PhD, Eva E. Qwarnstrom, PhD
Publikováno v:
JACC: Basic to Translational Science, Vol 2, Iss 4, Pp 398-414 (2017)
Expression of the interleukin-1 receptor type I (IL-1RI) co-receptor Toll-like and interleukin-1 receptor regulator (TILRR) is significantly increased in blood monocytes following myocardial infarction and in the atherosclerotic plaque, whereas level
Externí odkaz:
https://doaj.org/article/b66cef1d0265487f8eef2f4e9f8cc4bc
Autor:
Marwa M. Mahmoud, Jovana Serbanovic-Canic, Shuang Feng, Celine Souilhol, Rouyu Xing, Sarah Hsiao, Akiko Mammoto, Jing Chen, Markus Ariaans, Sheila E. Francis, Kim Van der Heiden, Victoria Ridger, Paul C. Evans
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Blood flow influences atherosclerosis by generating wall shear stress, which alters endothelial cell (EC) physiology. Low shear stress induces dedifferentiation of EC through a process termed endothelial-to-mesenchymal transition (EndMT). Th
Externí odkaz:
https://doaj.org/article/d73073520d3c4c1ea3aaec80eeedf382
Autor:
Marwa M. Mahmoud, Jovana Serbanovic-Canic, Shuang Feng, Celine Souilhol, Rouyu Xing, Sarah Hsiao, Akiko Mammoto, Jing Chen, Markus Ariaans, Sheila E. Francis, Kim Van der Heiden, Victoria Ridger, Paul C. Evans
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/f7db960ad367409a945ce2cf81ffa49f
Autor:
Mabruka A. Alfaidi, Janet Chamberlain, Alexander Rothman, David Crossman, Maria‐Cruz Villa‐Uriol, Patrick Hadoke, Junxi Wu, Torsten Schenkel, Paul C. Evans, Sheila E. Francis
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 7, Iss 13 (2018)
Background Hypertension is a complex condition and a common cardiovascular risk factor. Dietary docosahexaenoic acid (DHA) modulates atherosclerosis and hypertension, possibly via an inflammatory mechanism. IL‐1 (interleukin 1) has an established r
Externí odkaz:
https://doaj.org/article/26e4924d1e0a447e9174c5b62e220ede