Helicobacter pylori-induced histone modification, associated gene expression in gastric epithelial cells, and its implication in pathogenesis.

Autor: Song-Ze Ding, Wolfgang Fischer, Maria Kaparakis-Liaskos, George Liechti, D Scott Merrell, Patrick A Grant, Richard L Ferrero, Sheila E Crowe, Rainer Haas, Masanori Hatakeyama, Joanna B Goldberg

Publikováno v: PLoS ONE, Vol 5, Iss 4, p e9875 (2010)

Histone modifications are critical in regulating gene expression, cell cycle, cell proliferation, and development. Relatively few studies have investigated whether Helicobacter pylori, the major cause of human gastric diseases, affects histone modifi

Externí odkaz: https://doaj.org/article/5e6dee9faca74dd89a92655f15def404

A novel hypomorphic Apex1 mouse model implicates apurinic-apyrimidinic endonuclease 1 in oxidative DNA damage repair in gastric epithelial cells

Autor: David Rios-Covian, Lindsay D. Butcher, Amber L. Ablack, Gerco den Hartog, Mason T. Matsubara, Hong Ly, Andrew W. Oates, Guorong Xu, Kathleen M. Fisch, Eric T. Ahrens, Shusuke Toden, Corrie C. Brown, Kenneth Kim, Dzung Le, Lars Eckmann, Bithika Dhar, Tadahide Izumi, Peter B. Ernst, Sheila E. Crowe

While best known for its role in oxidative DNA damage repair, apurinic-apyrimidinic endonuclease-1 (APE1) is a multifunctional protein that regulates multiple host responses during oxidative stress including the reductive activation of transcription

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe004c4f6c31b2bf57a0dc06964a1723
http://hdl.handle.net/10029/625917

Safety and efficacy of AMG 714 in patients with type 2 refractory coeliac disease: a phase 2a, randomised, double-blind, placebo-controlled, parallel-group study

Autor: Ciaran P. Kelly, Garbiñe Roy Ariño, Anthony J. DiMarino, George Vlad, Laura Crespo, Raquel Perez Maseda, Amélie Trinquand, Ralph Raymond, Michael Schumann, Anne Blanchard, Olivier Hermine, Georgia Malamut, Jane R. Parnes, Samuli Rounioja, Eric Butz, Valerie Byrnes, Hetty J. Bontkes, Wayne Tsuji, Christophe Cellier, Gerd Bouma, Beth Llewellyn, Nadine Cerf-Bensussan, Tom van Gils, Peter H.R. Green, Joseph A. Murray, Govind Bhagat, Jack D. Bui, Ashleigh Palmer, Bana Jabri, Knut E.A. Lundin, Elizabeth Macintyre, Pekka Collin, Carlota García-Hoz, Sherine Khater, Bertrand Meresse, Francisco Leon, Chris J. J. Mulder, Sheila E. Crowe, David S Sanders, Michel Azizi, Marios Hadjivassiliou, Keijo Viiri

Publikováno v: Cellier, C, Bouma, G, van Gils, T, Khater, S, Malamut, G, Crespo, L, Collin, P, Green, P H R, Crowe, S E, Tsuji, W, Butz, E, Cerf-Bensussan, N, Macintyre, E, Parnes, J R, Leon, F, Hermine, O, Mulder, C J, Jabri, B, Murray, J, DiMarino, A, Kelly, C P, Byrnes, V, Sanders, D, Lundin, K E A, Schumann, M, Bontkes, H, Meresse, B, Roy Ariño, G, Bhagat, G, Viiri, K, Rounioja, S, Bui, J, Perez Maseda, R, García-Hoz, C, Trinquand, A, Vlad, G, Hadjivassiliou, M, Azizi, M, Blanchard, A, Llewellyn, B, Palmer, A & Raymond, R 2019, ' Safety and efficacy of AMG 714 in patients with type 2 refractory coeliac disease: a phase 2a, randomised, double-blind, placebo-controlled, parallel-group study ', The Lancet Gastroenterology and Hepatology, vol. 4, no. 12, pp. 960-970 . https://doi.org/10.1016/S2468-1253(19)30265-1
The Lancet Gastroenterology and Hepatology
The Lancet Gastroenterology and Hepatology, Elsevier, 2019, 4, pp.960-970. ⟨10.1016/S2468-1253(19)30265-1⟩
The Lancet Gastroenterology & Hepatology
The Lancet Gastroenterology & Hepatology, 2019, 4, pp.960-970. ⟨10.1016/S2468-1253(19)30265-1⟩
The Lancet Gastroenterology and Hepatology, 4(12), 960-970. Elsevier Ltd

Summary Background Refractory coeliac disease type 2 is a rare subtype of coeliac disease with high mortality rates; interleukin 15 (IL-15) is strongly implicated in its pathophysiology. This trial aimed to investigate the effects of AMG 714, an anti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f631e02be7147c01be92c9a499e939b5
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85074226957&origin=inward

Survey Finds Gender Disparities Impact Both Women Mentors and Mentees in Gastroenterology

Autor: Lucinda A Harris, Lauren Tal Grinspan, Christina Ha, Joann Kwah, Jennifer Christie, Olga C. Aroniadis, Rebekah E. Dixon, Jennifer M. Kolb, Shailja C. Shah, David A. Lieberman, David A. Greenwald, Haley M Zylberberg, Sheila E. Crowe, Laura E. Raffals, Michelle K. Kim, Loren Galler Rabinowitz, Karen L. Woods, Linda Lee, Austin Chiang, Nabil Fayad, Yakira N. David, Michael S Smith, Uzma D. Siddiqui, Douglas K. Rex, Cynthia W. Ko, Michael B. Wallace, Renee Williams, Nikhil A. Kumta

Publikováno v: The American journal of gastroenterology. 116(9)

INTRODUCTION: Gastroenterologists at all levels of practice benefit from formal mentoring. Much of the current literature on mentoring in gastroenterology is based on expert opinion rather than data. In this study, we aimed to identify gender-related

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::244c6cef6cefd7d51953768aa8ca88de
https://pubmed.ncbi.nlm.nih.gov/34140455

Metagenome Data on Intestinal Phage-Bacteria Associations Aids the Development of Phage Therapy against Pathobionts

Autor: Satoru Miyano, Peter B. Ernst, Takeshi Satoh, Masanori Kakuta, Kosuke Fujimoto, Yuki Usui, Yoichi Furukawa, Yoshikazu Yuki, Rui Yamaguchi, Hiroshi Kiyono, Yasumasa Kimura, Kiyoshi Yamaguchi, Koji Kashima, Yoshiko Nakano, Seiya Imoto, Miho Uematsu, Satoshi Uematsu, Shintaro Sato, Georg Tremmel, Tetsuya Hayashi, Sheila E. Crowe, Yutaka Akiyama, Masaki Shimohigoshi, Yunosuke Kawaguchi

Publikováno v: Cell hostmicrobe. 28(3)

Summary The application of bacteriophages (phages) is proposed as a highly specific therapy for intestinal pathobiont elimination. However, the infectious associations between phages and bacteria in the human intestine, which is essential information

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::930cc729551794f94a78cb37df79fa6e
https://pubmed.ncbi.nlm.nih.gov/32910916