Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Sheila Dakhel Plaza"'
A novel strategy to generate immunocytokines with activity-on-demand using small molecule inhibitors
Autor:
Giulia Rotta, Ettore Gilardoni, Domenico Ravazza, Jacqueline Mock, Frauke Seehusen, Abdullah Elsayed, Emanuele Puca, Roberto De Luca, Christian Pellegrino, Thomas Look, Tobias Weiss, Markus G Manz, Cornelia Halin, Dario Neri, Sheila Dakhel Plaza
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 4, Pp 904-926 (2024)
Abstract Cytokine-based therapeutics have been shown to mediate objective responses in certain tumor entities but suffer from insufficient selectivity, causing limiting toxicity which prevents dose escalation to therapeutically active regimens. The a
Externí odkaz:
https://doaj.org/article/3f9295ee87c944c5ae3975d61e53a157
Autor:
Lydia Bisbal Lopez, Domenico Ravazza, Matilde Bocci, Aureliano Zana, Lucrezia Principi, Sheila Dakhel Plaza, Andrea Galbiati, Ettore Gilardoni, Jörg Scheuermann, Dario Neri, Luca Pignataro, Cesare Gennari, Samuele Cazzamalli, Alberto Dal Corso
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Immune-stimulating antibody conjugates (ISACs) equipped with imidazoquinoline (IMD) payloads can stimulate endogenous immune cells to kill cancer cells, ultimately inducing long-lasting anticancer effects. A novel ISAC was designed, featuring the IMD
Externí odkaz:
https://doaj.org/article/b9edd8a96d8444cc849c81174ca18bed
Autor:
Abdullah Elsayed, Christian Pellegrino, Louis Plüss, Frederik Peissert, Ramon Benz, Franziska Ulrich, Gudrun Thorhallsdottir, Sheila Dakhel Plaza, Alessandra Villa, Jacqueline Mock, Emanuele Puca, Roberto De Luca, Markus G. Manz, Cornelia Halin, Dario Neri
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTAntibody-based therapeutics represent an important class of biopharmaceuticals in cancer immunotherapy. CD3 bispecific T-cell engagers activate cytotoxic T-cells and have shown remarkable clinical outcomes against several hematological malign
Externí odkaz:
https://doaj.org/article/0deae8b2479a4c3eace1b463b64d5b8f
Autor:
Louis Plüss, Frederik Peissert, Abdullah Elsayed, Giulia Rotta, Jonas Römer, Sheila Dakhel Plaza, Alessandra Villa, Emanuele Puca, Roberto De Luca, Annette Oxenius, Dario Neri
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTThere are no effective treatment options for most patients with metastatic colorectal cancer (mCRC). mCRC remains a leading cause of tumor-related death, with a five-year survival rate of only 15%, highlighting the urgent need for novel pharm
Externí odkaz:
https://doaj.org/article/b2b1ebf228944e2ba4c6dcab246edd47
Autor:
Samuele Cazzamalli, Dario Neri, Alessandra Villa, Emanuele Puca, Sheila Dakhel Plaza, Aureliano Zana, Christiane Krudewig, Jacopo Millul
Supplementary material: chemical synthesis and biological characterisation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b9a36294bfc4dcfa1d87db22b1b2b04
https://doi.org/10.1158/1535-7163.22521177
https://doi.org/10.1158/1535-7163.22521177
Autor:
Giulia Rotta, Ettore Gilardoni, Domenico Ravazza, Jacqueline Mock, Samuele Cazzamalli, Roberto De Luca, Emanuele Puca, Dario Neri, Sheila Dakhel Plaza
Publikováno v:
Cancer Research. 83:5744-5744
The use of cytokine-based therapeutics has traditionally been limited by systemic toxicity, but it is now becoming evident that it may be possible to circumvent this problem in a number of ways. Tumor-targeting antibody-cytokine fusion proteins (also
Autor:
Sheila Dakhel Plaza, Alessandra Villa, Emanuele Puca, Aureliano Zana, Christiane Krudewig, Samuele Cazzamalli, Dario Neri, Jacopo Millul
Small molecule-drug conjugates (SMDCs) represent an alternative to conventional antitumor chemotherapeutic agents, with the potential to improve the therapeutic window of cytotoxic payloads through active delivery at the site of the disease. In this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24d056a0eab26d5cf6bba637f56fa82b
https://www.zora.uzh.ch/id/eprint/196857/
https://www.zora.uzh.ch/id/eprint/196857/
Autor:
Etienne J. Donckele, Gabriele Bassi, Lisa Nadal, Jacopo Millul, Sheila Dakhel Plaza, Eleonore Schmidt, Christian Pellegrino, Abdullah Elsayed, Jacqueline Mock, Dario Neri, Aureliano Zana, Andreas Gloger, Samuele Cazzamalli, Florent Samain, Ilaria Biancofiore
Publikováno v:
Proc Natl Acad Sci U S A
We describe the development of OncoFAP, an ultra-high-affinity ligand of fibroblast activation protein (FAP) for targeting applications with pan-tumoral potential. OncoFAP binds to human FAP with affinity in the subnanomolar concentration range and c