Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Sheila B McLoughlin"'
Autor:
Ian M. Hardern, Jarrod Walsh, Ed Wheatley, Jon Winter-Holt, Sarita Maman, Judit E. Debreczeni, Graeme Walker, Susan E. Critchlow, Gareth M. Davies, Nicola J. Evans, Richard A. Ward, Neil P. Jones, Sheila B. McLoughlin, Andrew Peter Thomas, Neil Bennett, Geoff Holdgate, Nicola Curtis, Stephen A. St-Gallay, Lindsey Leach, Laurent Rigoreau, Andrew P. Turnbull, Marian Preston
Publikováno v:
SLAS discovery : advancing life sciences RD. 23(1)
A high-throughput screen (HTS) of human 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) resulted in several series of compounds with the potential for further optimization. Informatics was used to identify active chemotypes with lead-l
Autor:
Scott G. Lamont, James M. Smith, Joanna Brookfield, Edward R. Wheatley, Steve St-Gallay, Laurent Rigoreau, Sébastien L. Degorce, Jon Winter, Craig S. Donald, Scott Boyd, Julie K. Stock, Sam D. Groombridge, Philip Hopcroft, Nicola J. Evans, Iain A. Cumming, Nicola Curtis, Andrew P. Turnbull, Susan E. Critchlow, Judit E. Debreczeni, Sheila B. McLoughlin, Hilary J. Lewis, Philip MacFaull, Jonathan Wingfield, Neil P. Jones, Jason Grant Kettle
Publikováno v:
Journal of medicinal chemistry. 58(8)
A weak screening hit with suboptimal physicochemical properties was optimized against PFKFB3 kinase using critical structure-guided insights. The resulting compounds demonstrated high selectivity over related PFKFB isoforms and modulation of the targ
Publikováno v:
Pesticide Science. 55:364-367
This summary reports work with auxotrophs of the pathogenic fungus Stagonospora nodorum, the causal agent of leaf spot and glume blotch in wheat and barley, with a view to investigating the biochemical basis of pathogenicity. Biosynthetic enzymes may
Publikováno v:
Enzyme and Microbial Technology. 20:2-11
An analogue of the reactive textile dye, Cibacron Blue F3G-A, has been modified with nicotinamide to produce an artificial redox coenzyme, Blue N-3, whose properties reflect the dual presence of a blue anthraquinone chromophore and an n -substituted
Publikováno v:
Thrombosis research. 98(6)
Nafamostat mesilate (FUT-175), a synthetic serine protease inhibitor, is active against a number of the serine proteases involved in coagulation. This has been proposed as the basis of its anticoagulant activity. We investigated the reaction of Nafam
Publikováno v:
Journal of Chromatography A. 435:127-137
Terminal ring isomers of the reactive anthraquinone dye C.I. Reactive Blue 2 were synthesised and the reaction product and potential hydrolytic by-products analysed by thin-layer chromatography and reversed-phase high-performance liquid chromatograph
Publikováno v:
Investigational new drugs. 3(1)
The stability of the potential antitumour agent 2,5-diaziridinyl-3,6-bis(2 -hydroxyethylamino)-1,4-benzoquinone (BZQ; NSC 224070) has been investigated by high-performance liquid chromatography. At 22 degrees C in 0.05M buffer, BZQ was most stable at