Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Sheila A. Haley"'
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 8 (2024)
ABSTRACT The human polyomavirus, JCPyV, establishes a lifelong persistent infection in the peripheral organs of a majority of the human population worldwide. Patients who are immunocompromised due to underlying infections, cancer, or to immunomodulat
Externí odkaz:
https://doaj.org/article/7122b428b9004b4e8e801e62f3354361
Autor:
Jacob Kaiserman, Bethany A. O’Hara, Kaitlin Garabian, Avraham Lukacher, Sheila A. Haley, Walter J. Atwood
Publikováno v:
mBio, Vol 14, Iss 2 (2023)
ABSTRACT JC polyomavirus (JCPyV) is a ubiquitous, double-stranded DNA virus that causes the fatal demyelinating disease progressive multifocal leukoencephalopathy (PML) in immunocompromised patients. Current treatments for PML are limited to immune r
Externí odkaz:
https://doaj.org/article/3ed1f99adf52468f92ea6c8753b3d23f
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 10, p 8580 (2023)
Progressive multifocal leukoencephalopathy (PML) is a rare demyelinating disease caused by infection with JC Polyomavirus (JCPyV). Despite the identification of the disease and isolation of the causative pathogen over fifty years ago, no antiviral tr
Externí odkaz:
https://doaj.org/article/c09e13480712415d807ce734cbe54f50
Autor:
Jenna Morris‐Love, Bethany A. O'Hara, Gretchen V. Gee, Aisling S. Dugan, Ryan S. O'Rourke, Brandon E. Armstead, Benedetta Assetta, Sheila A. Haley, Walter J. Atwood
Publikováno v:
Journal of Extracellular Biology, Vol 1, Iss 5, Pp n/a-n/a (2022)
Abstract JC polyomavirus (JCPyV) is a small, non‐enveloped virus that persists in the kidney in about half the adult population. In severely immune‐compromised individuals JCPyV causes the neurodegenerative disease progressive multifocal leukoenc
Externí odkaz:
https://doaj.org/article/b6190895e19f49269ef28307c5ae5325
Teriflunomide Inhibits JCPyV Infection and Spread in Glial Cells and Choroid Plexus Epithelial Cells
Autor:
Bethany A. O’Hara, Gretchen V. Gee, Sheila A. Haley, Jenna Morris-Love, Charlotte Nyblade, Chris Nieves, Barbara A. Hanson, Xin Dang, Timothy J. Turner, Jeffrey M. Chavin, Alex Lublin, Igor J. Koralnik, Walter J. Atwood
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 18, p 9809 (2021)
Several classes of immunomodulators are used for treating relapsing-remitting multiple sclerosis (RRMS). Most of these disease-modifying therapies, except teriflunomide, carry the risk of progressive multifocal leukoencephalopathy (PML), a severely d
Externí odkaz:
https://doaj.org/article/8ba41656fae54f38a66af2a1e001d8cc
Autor:
Benedetta Assetta, Jenna Morris-Love, Gretchen V. Gee, Abigail L. Atkinson, Bethany A. O’Hara, Melissa S. Maginnis, Sheila A. Haley, Walter J. Atwood
Publikováno v:
Cell Reports, Vol 27, Iss 7, Pp 1960-1966.e6 (2019)
Summary: JC polyomavirus (JCPyV) is a ubiquitous human pathogen that causes progressive multifocal leukoencephalopathy (PML). The entry receptors for JCPyV belong to the 5-hydroxytryptamine 2 receptor (5-HT2R) family, but how individual members of th
Externí odkaz:
https://doaj.org/article/da94c8024abc44049449cc2a14f0b16a
Autor:
Jenna Morris-Love, Gretchen V. Gee, Bethany A. O’Hara, Benedetta Assetta, Abigail L. Atkinson, Aisling S. Dugan, Sheila A. Haley, Walter J. Atwood
Publikováno v:
mBio, Vol 10, Iss 2 (2019)
ABSTRACT The endemic human JC polyomavirus (JCPyV) causes progressive multifocal leukoencephalopathy in immune-suppressed patients. The mechanisms of virus infection in vivo are not understood because the major target cells for virus in the brain do
Externí odkaz:
https://doaj.org/article/ed0c2686dfa74786a627a85fd4ae68f3
Publikováno v:
Virology
The demyelinating disease progressive multifocal leukoencephalopathy (PML) is caused by the human polyomavirus, JCPyV, under conditions of prolonged immunosuppression. Initial infection is asymptomatic, and the virus establishes lifelong persistence
Publikováno v:
PLoS Pathogens, Vol 16, Iss 3, p e1008371 (2020)
PLoS Pathogens
PLoS Pathogens
The human polyomavirus, JCPyV, is the causative agent of progressive multifocal leukoencephalopathy (PML) in immunosuppressed and immunomodulated patients. Initial infection with JCPyV is common and the virus establishes a long-term persistent infect
Teriflunomide Inhibits JCPyV Infection and Spread in Glial Cells and Choroid Plexus Epithelial Cells
Autor:
Igor J. Koralnik, Charlotte Nyblade, Jenna Morris-Love, Xin Dang, Jeffrey Chavin, Alex L. Lublin, Gretchen V. Gee, Bethany A. O'Hara, Barbara A. Hanson, Sheila A. Haley, Walter J. Atwood, Timothy J. Turner, Chris Nieves
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 18
Pages: 9809
International Journal of Molecular Sciences, Vol 22, Iss 9809, p 9809 (2021)
Volume 22
Issue 18
Pages: 9809
International Journal of Molecular Sciences, Vol 22, Iss 9809, p 9809 (2021)
Several classes of immunomodulators are used for treating relapsing-remitting multiple sclerosis (RRMS). Most of these disease-modifying therapies, except teriflunomide, carry the risk of progressive multifocal leukoencephalopathy (PML), a severely d