Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Sheila A. Barber"'
Autor:
Gregory L. Szeto, Sheila A. Barber, Angela K. Brice, Hung-Chih Yang, Janice E. Clements, Robert F. Siliciano
Publikováno v:
The Journal of Infectious Diseases. 201:1132-1140
Human immunodeficiency virus (HIV)-infected patients must remain on a lifelong regimen of highly active antiretroviral therapy (HAART). The presence of a latent viral reservoir in resting CD4+ T cells necessitates long-term treatment to prevent HIV r
Publikováno v:
Journal of Biological Chemistry. 285:2258-2273
CCAAT/enhancer-binding protein (C/EBP) β and C/EBP sites in the HIV-1 long terminal repeat (LTR) are crucial for HIV-1 replication in monocyte/macrophages and for the ability of interferon β (IFNβ) to inhibit ongoing active HIV replication in thes
Autor:
M. Christine Zink, Ming Li, Janice E. Clements, Patrick M. Tarwater, John E. Anderson, Lucy M. Carruth, Sheila A. Barber, Tauni Voelker, Lucio Gama
Publikováno v:
The Journal of Infectious Diseases. 194:931-938
Background Before the onset of AIDS, replication of human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) in the lungs is considered to be latent. When and how virus replication is controlled in the lungs is unclear. In the prese
Protein kinase CK2 phosphorylates the Nef protein from a neurovirulent simian immunodeficiency virus
Publikováno v:
Virology. 348(1):156-164
The Nef protein of Human Immunodeficiency Virus (HIV) and Simian Immunodeficiency Virus (SIV) is a pluripotent accessory protein that plays a critical role in disease progression. One analogous characteristic of Nef proteins from SIV and HIV is the a
Publikováno v:
Journal of Virology. 77:8009-8018
The N terminus of the capsid protein (CA) undergoes a considerable conformational change when the human immunodeficiency virus (HIV) protease cleaves it free from the Pr55 Gag polyprotein. This rearrangement is thought to facilitate the establishment
Autor:
Rebecca J. Casaday, Janice E. Clements, Gary D. Coleman, M. Christine Zink, Jennifer L. Bennett, Sheila A. Barber, Emily D. Overholser
Publikováno v:
Journal of Virology. 77:6855-6866
As the most numerous cells in the brain, astrocytes play a critical role in maintaining central nervous system homeostasis, and therefore, infection of astrocytes by human immunodeficiency virus (HIV) or simian immunodeficiency virus (SIV) in vivo co
Autor:
Sheila A. Barber, Janice E. Clements, Brian R. Douglass, M. Christine Zink, Linda Bruett, David S. Herbst
Publikováno v:
Journal of Virology. 76:817-828
It is well accepted that viruses require access to specific intracellular environments in order to proliferate or, minimally, to secure future proliferative potential as latent reservoirs. Hence, identification of essential virus-cell interactions sh
Publikováno v:
Virology. 276(2):329-338
A functional Nef protein is crucial in vivo for viral replication leading to pathogenesis in SIV-infected macaques. Moreover, a full-length Nef protein is required for optimal virus replication in primary cells, and both HIV and SIV Nef proteins enha
Publikováno v:
Virology. 271:132-141
The identity of the cellular receptor(s) for visna virus, an ovine lentivirus, is currently unknown; however, previous studies from our laboratory have identified membrane-associated proteins expressed selectively in susceptible cells which bind visn
Publikováno v:
Infection and Immunity. 64:3397-3400
Recent studies have suggested that lipolysaccharide (LPS) stimulates cells by mimicking the second-messenger function of ceramide, a lipid generated in the cell by the action of sphingomyelinase (SMase). To examine this possibility further, we compar