Zobrazeno 1 - 10
of 138
pro vyhledávání: '"Sheila A Shurtleff"'
Autor:
Eric X. Wei, Vasiliki Leventaki, John K. Choi, Susana C. Raimondi, Elizabeth M. Azzato, Sheila A. Shurtleff, Menchu G. Ong, Diana M. Veillon, James D. Cotelingam, Rodney E. Shackelford
Publikováno v:
Case Reports in Hematology, Vol 2017 (2017)
Gamma delta (γδ) T-cell antigen receptor (TCR) expression and its related T-cell differentiation are not commonly reported in T-cell acute lymphoblastic leukemia/lymphoma (T-ALL). Here we report two pediatric T-ALL cases and present their clinical
Externí odkaz:
https://doaj.org/article/81f1594caaf947f3b5fda567be040c4d
Autor:
Lei Wang, Raul C. Ribeiro, Stanley Pounds, Sara M. Federico, Lie Li, John C. Panetta, Ching-Hon Pui, Jeffrey E. Rubnitz, Aksana Vasilyeva, Tanja A. Gruber, Sheila A. Shurtleff, Yong-Dong Wang, Sharyn D. Baker, Fariba Navid, Eric D. Eisenmann, Hiroto Inaba
Publikováno v:
Clin Cancer Res
Purpose: To determine the pharmacokinetics and skin toxicity profile of sorafenib in children with refractory/relapsed malignancies. Patients and Methods: Sorafenib was administered concurrently or sequentially with clofarabine and cytarabine to pati
Autor:
David Finkelstein, Reid Palumbo, Jeffrey E. Rubnitz, Dominique Garrison, Geoffrey Neale, Daelynn R. Buelow, Hiroto Inaba, Tanja A. Gruber, Karl Kroll, Lei Shi, Sheila A. Shurtleff, Yongjin Li, Yong-Dong Wang, Raul C. Ribeiro, John C. Byrd, Stanley Pounds, James S. Blachly, Shelley Orwick, Sharyn D. Baker
Publikováno v:
Clinical and Translational Science
Clinical and Translational Science, Vol 12, Iss 6, Pp 641-647 (2019)
Clinical and Translational Science, Vol 12, Iss 6, Pp 641-647 (2019)
Fms-like tyrosine kinase 3 (FLT3) internal tandem duplication (ITD) mutations, common in pediatric acute myeloid leukemia (AML), associate with early relapse and poor prognosis. Past studies have suggested additional cooperative mutations are require
Autor:
David W. Ellison, Seungjae Lee, Stephen V. Rice, Alberto S. Pappo, Heather L. Mulder, Elizabeth M Azzato, Sheila A. Shurtleff, Liying Fan, Raymond L. Barnhill, Scott Newman, Joy Nakitandwe, Bridget Shaner, Antonina Silkov, Xin Zhou, Philip M. Potter, Kim E. Nichols, Jinghui Zhang, Armita Bahrami, Ying Shao, John Easton, James R. Downing, Allison Pribnow, Gang Wu
Publikováno v:
Nat Med
Spitzoid melanoma is a specific morphologic variant of melanoma that most commonly affects children and adolescents, and ranges on the spectrum of malignancy from low grade to overtly malignant. These tumors are generally driven by fusions of ALK, RE
Autor:
Samuel W. Brady, Brent A. Orr, Jamie L. Maciaszek, Michael N. Edmonson, Michael Rusch, Yu Liu, Andrew Thrasher, Aman Patel, Jessica M. Valdez, Xin Zhou, Scott G. Foy, Jeffery M. Klco, Lu Wang, Stacy Hines-Dowell, Eric Davis, James R. Downing, Jiali Gu, Liza-Marie Johnson, Rose B. McGee, Scott Newman, Roya Mostafavi, Zhaohui Gu, Jian Wang, Armita Bahrami, Sheila A. Shurtleff, Delaram Rahbarinia, Dale Hedges, Lynn W. Harrison, Jay Knight, Ching-Hon Pui, Jared Becksfort, Manish Kubal, Giles W. Robinson, Emily Quinn, Leslie Taylor, Annastasia A. Ouma, Elizabeth M Azzato, Ti-Cheng Chang, Charles G. Mullighan, Yanling Liu, Joy Nakitandwe, Victor B Pastor, Michael R. Clay, Antonina Silkov, Jinghui Zhang, Manjusha Pande, Chimene Kesserwan, Kayla V. Hamilton, Alexander M. Gout, David A. Wheeler, David W. Ellison, Elsie L. Gerhardt, Kim E. Nichols, Zhaojie Zhang, Alberto S. Pappo, Regina Nuccio, Mark R. Wilkinson
Publikováno v:
Cancer Discov
Genomic studies of pediatric cancer have primarily focused on specific tumor types or high-risk disease. Here, we used a three-platform sequencing approach, including whole-genome sequencing (WGS), whole-exome sequencing (WES), and RNA sequencing (RN
Autor:
Josephine K Dermawan, Youran Zou, Sheila A Shurtleff, Scott E. Kilpatrick, Steven D. Billings, Yu-Wei Cheng, Zheng Jin Tu, Elizabeth M Azzato, John D. Reith, Omar Habeeb, Brian P. Rubin, John R. Goldblum, Daniel H. Farkas, Anders Meyer
Publikováno v:
Archives of pathologylaboratory medicine. 145(7)
Context.— Bone and soft tissue tumors are heterogeneous, diagnostically challenging, and often defined by gene fusions. Objective.— To present our experience using a custom 34-gene targeted sequencing fusion panel. Design.— Total nucleic acid e
Autor:
Andrew Thrasher, Michael Rusch, Ruth G. Tatevossian, Yanling Liu, Joy Nakitandwe, Xiang Chen, Tanja A. Gruber, Jeffery M. Klco, Dale Hedges, Matthew Parker, Bhavin Vadodaria, Xiaotu Ma, Michael N. Edmonson, Susana C. Raimondi, Rose B. McGee, Scott Newman, Donald Yergeau, Sheila A. Shurtleff, Erin Hedlund, John Easton, Kohei Hagiwara, Aman Patel, James R. Downing, Michael Walsh, James McMurry, Jiali Gu, Giles W. Robinson, David W. Ellison, Jinghui Zhang, Yongjin Li, Zhaojie Zhang, Jared Becksfort, Yuannian Jiao
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Nature Communications
Nature Communications
To evaluate the potential of an integrated clinical test to detect diverse classes of somatic and germline mutations relevant to pediatric oncology, we performed three-platform whole-genome (WGS), whole exome (WES) and transcriptome (RNA-Seq) sequenc
Hypoxia-induced upregulation of BMX kinase mediates therapeutic resistance in acute myeloid leukemia
Autor:
Lie Li, Stanley Pounds, Jeffrey E. Rubnitz, Aksana Vasilyeva, Navjotsingh Pabla, David Finkelstein, Daelynn R. Buelow, Lei Shi, Jolieke G. van Oosterwijk, Hiroto Inaba, Laura J. Janke, Sharyn D. Baker, Christina D. Drenberg, Sheila A. Shurtleff, Yong-Dong Wang
Publikováno v:
Journal of Clinical Investigation. 128:369-380
Oncogenic addiction to the Fms-like tyrosine kinase 3 (FLT3) is a hallmark of acute myeloid leukemia (AML) that harbors the FLT3-internal tandem duplication (FLT3-ITD) mutation. While FLT3 inhibitors like sorafenib show initial therapeutic efficacy,
Autor:
Xiaoyu Li, James Dalton, Azzam Ismail, Suash Sharma, Santhosh A. Upadhyaya, Annette D. Segura, Sheila A. Shurtleff, Jason Chiang, Ibrahim Qaddoumi, Zoltan Patay, Susana C. Raimondi
Publikováno v:
Acta Neuropathologica. 137:179-181
Autor:
Andrew Thrasher, Samuel W. Brady, Yu Liu, Brent A. Orr, Roya Mostafavi, Scott G. Foy, Mark C. Wilkinson, Liza-Marie Johnson, Jinghui Zhang, Antonina Silkov, Lynn W. Harrison, David A. Wheeler, Elizabeth M Azzato, Chimene Kesserwan, Lu Wang, Armita Bahrami, Alberto S. Pappo, Stacy Hines-Dowell, Leslie Taylor, Regina Nuccio, Charles G. Mullighan, Manish Kubal, Yanling Liu, Joy Nakitandwe, Jay Knight, David W. Ellison, Elsie L. Gerhardt, Rose B. McGee, Scott Newman, Kim E. Nichols, Jeffery M. Klco, Jing Wang, Michael R. Clay, Michael N. Edmonson, James R. Downing, Xin Zhou, Sheila A. Shurtleff, Delaram Rahbarinia, Dale J. Hedges, Giles W. Robinson, Emily Quinn, Jamie L. Maciaszek, Jessica M. Valdez, Jiali Gu, Ching-Hon Pui, Kayla V. Hamilton, Michael Rusch, Zhaojie Zhang, Annastasia A. Ouma
Publikováno v:
Cancer Research. 81:642-642
Clinical genomic studies of pediatric cancer have primarily focused on specific tumor types or high-risk disease. In the Genomes for Kids study (NCT02530658) we used a three-platform sequencing approach, including whole genome (WGS), whole exome (WES