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Hyperbaric oxygenation enhances transplanted cell graft and functional recovery in the infarct heart

Autor: Brian K. Rivera, Periannan Kuppusamy, Robert L. Hamlin, M. Lakshmi Kuppusamy, Sheik Wisel, Sarath Meduru, Iyyapu Krishna Mohan, Aditi C. Kulkarni, Mahmood Khan

Publikováno v: Journal of Molecular and Cellular Cardiology. 47:275-287

A major limitation to the application of stem-cell therapy to repair ischemic heart damage is the low survival of transplanted cells in the heart, possibly due to poor oxygenation. We hypothesized that hyperbaric oxygenation (HBO) can be used as an a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2536a24e9cde6cfe2ba9d61d468aa86
https://doi.org/10.1016/j.yjmcc.2009.04.005

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Pharmacological Preconditioning of Mesenchymal Stem Cells with Trimetazidine (1-[2,3,4-Trimethoxybenzyl]piperazine) Protects Hypoxic Cells against Oxidative Stress and Enhances Recovery of Myocardial Function in Infarcted Heart through Bcl-2 Expression

Autor: Simi M. Chacko, Sheik Wisel, M. Lakshmi Kuppusamy, I. Krishna Mohan, Periannan Kuppusamy, Benjamin Sun, Kálmán Hideg, Mahmood Khan, Brian K. Rivera

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 329:543-550

Stem cell transplantation is a possible therapeutic option to repair ischemic damage to the heart. However, it is faced with a number of challenges including the survival of the transplanted cells in the ischemic region. The present study was designe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34a61567191d961d03b0667355728c08
https://doi.org/10.1124/jpet.109.150839

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Cardioprotection by HO-4038, a novel verapamil derivative, targeted against ischemia and reperfusion-mediated acute myocardial infarction

Autor: Arun Sridhar, Iyyapu Krishna Mohan, Sheik Wisel, Tamás Kálai, Karuppaiyah Selvendiran, Periannan Kuppusamy, Cynthia A. Carnes, Kálmán Hideg, Mahmood Khan, Balázs Bognár

Publikováno v: American Journal of Physiology-Heart and Circulatory Physiology. 296:H140-H151

Many cardiac interventional procedures, such as coronary angioplasty, stenting, and thrombolysis, attempt to reintroduce blood flow (reperfusion) to an ischemic region of myocardium. However, the reperfusion is accompanied by a complex cascade of cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10fc14b04f62e0343453ef09d0fd7e0f
https://doi.org/10.1152/ajpheart.00687.2008

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Skeletal myoblasts transplanted in the ischemic myocardium enhance in situ oxygenation and recovery of contractile function

Autor: Sheik Wisel, Vijay Kumar Kutala, Simi M. Chacko, Pawel Kwiatkowski, Mahmood Khan, Iyyapu Krishna Mohan, Deepti S. Vikram, Jay L. Zweier, M. Lakshmi Kuppusamy, Periannan Kuppusamy

Publikováno v: American Journal of Physiology-Heart and Circulatory Physiology. 293:H2129-H2139

It is unclear whether oxygen plays a role in stem cell therapy. Hence, the determination of local oxygenation (Po2) in the infarct heart and at the site of transplantation may be critical to study the efficacy of cell therapy. To demonstrate this, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::877723f751531bfc157376e53dd55efd
https://doi.org/10.1152/ajpheart.00677.2007

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Labeling of skeletal myoblasts with a novel oxygen-sensing spin probe for noninvasive monitoring of in situ oxygenation and cell therapy in heart

Autor: Periannan Kuppusamy, Pawel Kwiatkowski, Vijay Kumar Kutala, M. Lakshmi Kuppusamy, Mahmood Khan, Benjamin Sun, Ramasamy P. Pandian, Richard W. Burry, Simi M. Chacko, Sheik Wisel

Publikováno v: American Journal of Physiology-Heart and Circulatory Physiology. 292:H1254-H1261

We report the labeling (internalization) of skeletal myoblasts (SMs) with a novel class of oxygen-sensing paramagnetic spin probe for noninvasive tracking and in situ monitoring of oxygenation in stem cell therapy using electron paramagnetic resonanc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::390214c039021e2cbb0d3ef11f84c6c5
https://doi.org/10.1152/ajpheart.01058.2006

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Mechanism of inhibition of proton: Dipeptide co-transport during chronic enteritis in the mammalian small intestine

Autor: Steven Coon, Sheik Wisel, Uma Sundaram

Publikováno v: Biochimica et Biophysica Acta (BBA) - Biomembranes. 1714:134-140

Amino acids, a critical energy source for the intestinal epithelial cells, are more efficiently assimilated in the normal intestine via peptide co-transporters such as proton:dipeptide co-transport (such as PepT1). Active uptake of a non-hydrolyzable

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03ffa8b74cf2312aa329d3214d0c0824
https://doi.org/10.1016/j.bbamem.2005.06.007

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Smooth muscle cell expression of a constitutive active form of human Rac 1 accelerates cutaneous wound repair

Autor: Hamdy H. Hassanain, Robert E. Michler, Sheik Wisel, Fawzi I. Irshaid, Pascal J. Goldschmidt-Clermont, John F. Sheridan

Publikováno v: Surgery. 137:92-101

Hyperoxia has been shown to improve wound healing; however, the mechanism for such therapeutic effects of oxygen remains hypothetical. Rac 1 regulates a wide variety of cellular activities, including cell proliferation and migration, and also is a ke

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6d872bd52524d31969275502a993e71
https://doi.org/10.1016/j.surg.2004.06.012

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Mechanism of inhibition of Na+-bile acid cotransport during chronic ileal inflammation in rabbits

Autor: W. Kramer, Vazhaikkurichi M. Rajendran, Sheik Wisel, Uma Sundaram, S. Stengelin

Publikováno v: American Journal of Physiology-Gastrointestinal and Liver Physiology. 275:G1259-G1265

In the chronically inflamed ileum, unique mechanisms of alteration of similar transport processes suggest regulation by different immune-inflammatory mediator pathways. In a rabbit model of chronic ileitis, we previously demonstrated that Na+-glucose

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5878cb49c76ecafbbd15b9d71042bbe4
https://doi.org/10.1152/ajpgi.1998.275.6.g1259

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Unique mechanism of inhibition of Na+-amino acid cotransport during chronic ileal inflammation

Autor: Uma Sundaram, Sheik Wisel, John J. Fromkes

Publikováno v: American Journal of Physiology-Gastrointestinal and Liver Physiology. 275:G483-G489

In the chronically inflamed ileum, unique mechanisms of alteration of transport processes suggest regulation by different immune-inflammatory mediator pathways. We previously demonstrated that Na+-glucose cotransport in the chronically inflamed ileum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00a545f754b989699226d4f976cf0441
https://doi.org/10.1152/ajpgi.1998.275.3.g483

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Measurement of oxygenation at the site of stem cell therapy in a murine model of myocardial infarction

Autor: Mahmood, Khan, Vijay Kumar, Kutala, Sheik, Wisel, Simi M, Chacko, M Lakshmi, Kuppusamy, Pawel, Kwiatkowski, Periannan, Kuppusamy

Publikováno v: Advances in experimental medicine and biology. 614

We have developed a noninvasive EPR (electron paramagnetic resonance) oximetry, based on a new class of oxygen-sensing nano-particulate probe (LiNc-BuO), for simultaneous monitoring of stem-cell therapy and in situ oxygenation (partial pressure of ox

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c8e34a4473ccf4e7dffed98e5063557e
https://pubmed.ncbi.nlm.nih.gov/18290313

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