Zobrazeno 1 - 10
of 316
pro vyhledávání: '"Shehzad Z"'
Autor:
Kevin A. Chen, Nina C. Nishiyama, Meaghan M. Kennedy Ng, Alexandria Shumway, Chinmaya U. Joisa, Matthew R. Schaner, Grace Lian, Caroline Beasley, Lee-Ching Zhu, Surekha Bantumilli, Muneera R. Kapadia, Shawn M. Gomez, Terrence S. Furey, Shehzad Z. Sheikh
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Pediatric Crohn’s disease (CD) is characterized by a severe disease course with frequent complications. We sought to apply machine learning-based models to predict risk of developing future complications in pediatric CD using ileal and col
Externí odkaz:
https://doaj.org/article/979e1b72de6f43b790ae2ed45066b834
Autor:
Daniel S. Levic, Donna Niedzwiecki, Apoorva Kandakatla, Norah S. Karlovich, Arjun Juneja, Jieun Park, Christina Stolarchuk, Shanté Adams, Jason R. Willer, Matthew R. Schaner, Grace Lian, Caroline Beasley, Lindsay Marjoram, Ann D. Flynn, John F. Valentine, Jane E. Onken, Shehzad Z. Sheikh, Erica E. Davis, Kimberley J. Evason, Katherine S. Garman, Michel Bagnat
Publikováno v:
Gastro Hep Advances, Vol 3, Iss 7, Pp 888-898 (2024)
Background and Aims: Inflammatory bowel diseases (IBDs) are chronic inflammatory conditions influenced heavily by environmental factors. DNA methylation is a form of epigenetic regulation linking environmental stimuli to gene expression changes and i
Externí odkaz:
https://doaj.org/article/5c811e8cbcfe49d3801475d29dc0ac64
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 4, p e1012016 (2024)
Network inference is used to model transcriptional, signaling, and metabolic interactions among genes, proteins, and metabolites that identify biological pathways influencing disease pathogenesis. Advances in machine learning (ML)-based inference mod
Externí odkaz:
https://doaj.org/article/b1ab8fd8c9594b759b646aa4f6e8e1ba
Autor:
Matt Kanke, Meaghan M. Kennedy Ng, Sean Connelly, Manvendra Singh, Matthew Schaner, Michael T. Shanahan, Elizabeth A. Wolber, Caroline Beasley, Grace Lian, Animesh Jain, Millie D. Long, Edward L. Barnes, Hans H. Herfarth, Kim L. Isaacs, Jonathon J. Hansen, Muneera Kapadia, Jose Gaston Guillem, Cedric Feschotte, Terrence S. Furey, Shehzad Z. Sheikh, Praveen Sethupathy
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 6, Pp 1717-1740 (2022)
Background & Aims: The intestinal barrier comprises a monolayer of specialized intestinal epithelial cells (IECs) that are critical in maintaining mucosal homeostasis. Dysfunction within various IEC fractions can alter intestinal permeability in a ge
Externí odkaz:
https://doaj.org/article/f26eceddd75d46159db62af17e2aa45c
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Inflammatory bowel diseases (IBD), namely Crohn’s disease (CD) and ulcerative colitis (UC) are chronic inflammation within the gastrointestinal tract. IBD patient conditions and treatments, such as with immunosuppressants, may result in a
Externí odkaz:
https://doaj.org/article/af484fe13ad24c15be1b2662e6515b23
Autor:
Takahiko Toyonaga, Kenza C. Araba, Meaghan M. Kennedy, Benjamin P. Keith, Elisabeth A. Wolber, Caroline Beasley, Erin C. Steinbach, Matthew R. Schaner, Animesh Jain, Millie D. Long, Edward L. Barnes, Hans H. Herfarth, Kim L. Isaacs, Jonathan J. Hansen, Muneera R. Kapadia, José Gaston Guillem, Ajay S. Gulati, Praveen Sethupathy, Terrence S. Furey, Camille Ehre, Shehzad Z. Sheikh
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract The host receptor for SARS-CoV-2, angiotensin-converting enzyme 2 (ACE2), is highly expressed in small intestine. Our aim was to study colonic ACE2 expression in Crohn's disease (CD) and non-inflammatory bowel disease (non-IBD) controls. We
Externí odkaz:
https://doaj.org/article/46dc769554ff4a93a33f60385762e0c7
Autor:
Takahiko Toyonaga, Erin C. Steinbach, Benjamin P. Keith, Jasmine B. Barrow, Matthew R. Schaner, Elisabeth A. Wolber, Caroline Beasley, Jennifer Huling, Yuli Wang, Nancy L. Allbritton, Nicole Chaumont, Timothy S. Sadiq, Mark J. Koruda, Animesh Jain, Millie D. Long, Edward L. Barnes, Hans H. Herfarth, Kim L. Isaacs, Jonathan J. Hansen, Michael T. Shanahan, Reza Rahbar, Terrence S. Furey, Praveen Sethupathy, Shehzad Z. Sheikh
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 4, Pp 779-796 (2020)
Background & Aims: Intestinal epithelial cell (IEC) barrier dysfunction is critical to the development of Crohn’s disease (CD). However, the mechanism is understudied. We recently reported increased microRNA-31-5p (miR-31-5p) expression in colonic
Externí odkaz:
https://doaj.org/article/36b046e473024c52aed5f45964b4cb72
BET Protein Inhibition Regulates Macrophage Chromatin Accessibility and Microbiota-Dependent Colitis
Autor:
Michelle Hoffner O’Connor, Ana Berglind, Meaghan M. Kennedy Ng, Benjamin P. Keith, Zachary J. Lynch, Matthew R. Schaner, Erin C. Steinbach, Jeremy Herzog, Omar K. Trad, William R. Jeck, Janelle C. Arthur, Jeremy M. Simon, R. Balfour Sartor, Terrence S. Furey, Shehzad Z. Sheikh
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
IntroductionIn colitis, macrophage functionality is altered compared to normal homeostatic conditions. Loss of IL-10 signaling results in an inappropriate chronic inflammatory response to bacterial stimulation. It remains unknown if inhibition of bro
Externí odkaz:
https://doaj.org/article/16bc63fbe0be4e3aa778fb80c11bd93c
Autor:
Vincent J. Lynch, Mauris C. Nnamani, Aurélie Kapusta, Kathryn Brayer, Silvia L. Plaza, Erik C. Mazur, Deena Emera, Shehzad Z. Sheikh, Frank Grützner, Stefan Bauersachs, Alexander Graf, Steven L. Young, Jason D. Lieb, Francesco J. DeMayo, Cédric Feschotte, Günter P. Wagner
Publikováno v:
Cell Reports, Vol 10, Iss 4, Pp 551-561 (2015)
A major challenge in biology is determining how evolutionarily novel characters originate; however, mechanistic explanations for the origin of new characters are almost completely unknown. The evolution of pregnancy is an excellent system in which to
Externí odkaz:
https://doaj.org/article/160dd80e03d34e2d89920f43dc99d149
Autor:
Colin R Lickwar, J Gray Camp, Matthew Weiser, Jordan L Cocchiaro, David M Kingsley, Terrence S Furey, Shehzad Z Sheikh, John F Rawls
Publikováno v:
PLoS Biology, Vol 15, Iss 8, p e2002054 (2017)
The intestinal epithelium serves critical physiologic functions that are shared among all vertebrates. However, it is unknown how the transcriptional regulatory mechanisms underlying these functions have changed over the course of vertebrate evolutio
Externí odkaz:
https://doaj.org/article/580fa25accc343b88905af774dc81b4e