Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Shehrazade Dahimene"'
Publikováno v:
Channels, Vol 17, Iss 1 (2023)
ABSTRACTIn this hybrid review, we have first collected and reviewed available information on the structure and function of the enigmatic cache domains in α2δ proteins. These are organized into two double cache (dCache_1) domains, and they are prese
Externí odkaz:
https://doaj.org/article/29b85d8ff155416898076adb66684e7c
Autor:
James O. Meyer, Shehrazade Dahimene, Karen M. Page, Laurent Ferron, Ivan Kadurin, Joseph I.J. Ellaway, Pengxiang Zhao, Tarun Patel, Simon W. Rothwell, Peipeng Lin, Wendy S. Pratt, Annette C. Dolphin
Publikováno v:
Cell Reports, Vol 29, Iss 1, Pp 22-33.e5 (2019)
Summary: Voltage-gated calcium channels are exquisitely Ca2+ selective, conferred primarily by four conserved pore-loop glutamate residues contributing to the selectivity filter. There has been little previous work directly measuring whether the traf
Externí odkaz:
https://doaj.org/article/b96fac46c3774fd5a3d05be757aa82e6
Autor:
Shehrazade Dahimene, Leonie von Elsner, Tess Holling, Lauren S Mattas, Jess Pickard, Davor Lessel, Kjara S Pilch, Ivan Kadurin, Wendy S Pratt, Igor B Zhulin, Hongzheng Dai, Maja Hempel, Maura R Z Ruzhnikov, Kerstin Kutsche, Annette C Dolphin
Publikováno v:
Brain. 145:2721-2729
Voltage-gated calcium (CaV) channels form three subfamilies (CaV1–3). The CaV1 and CaV2 channels are heteromeric, consisting of an α1 pore-forming subunit, associated with auxiliary CaVβ and α2δ subunits. The α2δ subunits are encoded in mamma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd78b4c0491c3ddb74515f9a26788920
https://doi.org/10.1093/brain/awac081
https://doi.org/10.1093/brain/awac081
Autor:
Shehrazade Dahimene, Karen M. Page, Manuela Nieto-Rostro, Wendy S. Pratt, Marianna D'Arco, Annette C. Dolphin
Publikováno v:
Neurobiology of Disease, Vol 93, Iss , Pp 243-256 (2016)
Episodic ataxia 2 (EA2) is an autosomal dominant disorder caused by mutations in the gene CACNA1A that encodes the pore-forming CaV2.1 calcium channel subunit. The majority of EA2 mutations reported so far are nonsense or deletion/insertion mutations
Externí odkaz:
https://doaj.org/article/7f9c96e2028b44edbadf8d67e0de0f2f
Autor:
Shehrazade Dahimene, Karen M. Page, Ivan Kadurin, Laurent Ferron, Dominique Y. Ho, Gareth T. Powell, Wendy S. Pratt, Stephen W. Wilson, Annette C. Dolphin
Publikováno v:
Cell Reports, Vol 25, Iss 6, Pp 1610-1621.e5 (2018)
Summary: Voltage-gated calcium channel auxiliary α2δ subunits are important for channel trafficking and function. Here, we compare the effects of α2δ-1 and an α2δ-like protein called Cachd1 on neuronal N-type (CaV2.2) channels, which are import
Externí odkaz:
https://doaj.org/article/18afc7732ea249b79a59826d0608911d
Autor:
Ivan, Kadurin, Shehrazade, Dahimene, Karen M, Page, Joseph I J, Ellaway, Kanchan, Chaggar, Linda, Troeberg, Hideaki, Nagase, Annette C, Dolphin
Publikováno v:
Function (Oxford, England). 3(3)
The auxiliary α
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7899afe1c9d8ef6e460883255c51df7a
https://pubmed.ncbi.nlm.nih.gov/35462614
https://pubmed.ncbi.nlm.nih.gov/35462614
Autor:
Ivan Kadurin, Linda Troeberg, Hideaki Nagase, Joseph I. J. Ellaway, Kanchan Chaggar, Shehrazade Dahimene, Annette C. Dolphin, Karen M. Page
The auxiliary α2δ subunits of voltage-gated calcium (CaV) channels are key to augmenting expression and function of CaV1 and CaV2 channels, and are also important drug targets in several therapeutic areas, including neuropathic pain. The α2δ prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78e5967f3caca64e750352624fb479fa
https://doi.org/10.1101/2021.04.29.441911
https://doi.org/10.1101/2021.04.29.441911
Autor:
Wendy S. Pratt, Laurent Ferron, Samuel Heyes, Michael John Owen, Annette C. Dolphin, Shehrazade Dahimene, Elliott Rees
Publikováno v:
Progress in Neurobiology
Highlights • Voltage-gated calcium channel classification—genes and proteins. • Genetic analysis of neuropsychiatric syndromes. • Calcium channel genes identified from GWA studies of psychiatric disorders. • Rare mutations in calcium channe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d27068f9075f3963c209b4b8829c0888
https://doi.org/10.1016/j.pneurobio.2015.09.002
https://doi.org/10.1016/j.pneurobio.2015.09.002
Autor:
Dahimene, Shehrazade1 (AUTHOR), Page, Karen M1 (AUTHOR), Nieto-Rostro, Manuela1 (AUTHOR), Pratt, Wendy S1 (AUTHOR), Dolphin, Annette C1 (AUTHOR) a.dolphin@ucl.ac.uk
Publikováno v:
Function. 2024, Vol. 5 Issue 1, p1-12. 12p.
Autor:
Shehrazade Dahimene, Karen M. Page, Manuela Nieto-Rostro, Wendy S. Pratt, Marianna D'Arco, Annette C. Dolphin
Publikováno v:
Neurobiology of Disease
Neurobiology of Disease, Vol 93, Iss, Pp 243-256 (2016)
Neurobiology of Disease, Vol 93, Iss, Pp 243-256 (2016)
Episodic ataxia 2 (EA2) is an autosomal dominant disorder caused by mutations in the gene CACNA1A that encodes the pore-forming CaV2.1 calcium channel subunit. The majority of EA2 mutations reported so far are nonsense or deletion/insertion mutations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::4a73e4e05fcb27125ade291869f76764