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pro vyhledávání: '"Shegufta N. Farazi"'
Autor:
Robert Chapman, Shelli R. McAlpine, Shegufta N. Farazi, Raelene Boquiren, Henry Foster, Fan Chen
Publikováno v:
Polymer Chemistry. 11:425-432
Nanogels are attractive delivery vehicles for small hydrophilic cargo, such as peptides, but there is a limited understanding of how the structure of both the nanogel and cargo affect the drug loading and release properties, particularly in biologica
Publikováno v:
Chemical communications (Cambridge, England). 55(31)
LB76 is a cyclic peptide that shows great promise as a selective heat shock protein 90 (Hsp90) inhibitor. However despite strong binding to and inhibition of Hsp90 in cell lysate its polar structure prevents it from crossing the cell membrane. We hav