Zobrazeno 1 - 10
of 183
pro vyhledávání: '"Sheetij Dutta"'
Autor:
Christopher J. Genito, Katherine Brooks, Alexis Smith, Emma Ryan, Kim Soto, Yuanzhang Li, Lucile Warter, Sheetij Dutta
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-11 (2023)
Abstract Mouse models are useful for the early down-selection of malaria vaccine candidates. The Walter Reed Army Institute of Research has optimized a transgenic Plasmodium berghei sporozoite challenge model to compare the efficacy of Plasmodium fal
Externí odkaz:
https://doaj.org/article/91e96a6545a0456d803561260907784c
Autor:
Kan Li, Michael Dodds, Rachel L. Spreng, Milite Abraha, Richard H. C. Huntwork, Lindsay C. Dahora, Tinashe Nyanhete, Sheetij Dutta, Ulrike Wille-Reece, Erik Jongert, Katie J. Ewer, Adrian V. S. Hill, Celina Jin, Jennifer Hill, Andrew J. Pollard, S. Munir Alam, Georgia D. Tomaras, S. Moses Dennison
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Diversity in specificity of polyclonal antibody (pAb) responses is extensively investigated in vaccine efficacy or immunological evaluations, but the heterogeneity in antibody avidity is rarely probed as convenient tools are lacking. Here we have dev
Externí odkaz:
https://doaj.org/article/daa2eeeb0ae945ebaa3a3cfd1fe010ec
Autor:
Mark D. Langowski, Farhat A. Khan, Sofya Savransky, Dallas R. Brown, Arasu Balasubramaniyam, William B. Harrison, Xiaoyan Zou, Zoltan Beck, Gary R. Matyas, Jason A. Regules, Robin Miller, Lorraine A. Soisson, Adrian H. Batchelor, Sheetij Dutta
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-11 (2022)
Abstract The Circumsporozoite Protein (CSP) of Plasmodium falciparum contains an N-terminal region, a conserved Region I (RI), a junctional region, 25–42 copies of major (NPNA) and minor repeats followed by a C-terminal domain. The recently approve
Externí odkaz:
https://doaj.org/article/0da9d7df686a4d03baf0a5d54ff2c7f7
Autor:
Kelly E. Seaton, Rachel L. Spreng, Milite Abraha, Matthew Reichartz, Michelle Rojas, Frederick Feely, Richard H. C. Huntwork, Sheetij Dutta, Sarah V. Mudrak, S. Munir Alam, Scott Gregory, Erik Jongert, Margherita Coccia, Fernando Ulloa-Montoya, Ulrike Wille-Reece, Georgia D. Tomaras, S. Moses Dennison
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-13 (2021)
Abstract RTS,S/AS01 is an advanced pre-erythrocytic malaria vaccine candidate with demonstrated vaccine efficacy up to 86.7% in controlled human malaria infection (CHMI) studies; however, reproducible immune correlates of protection (CoP) are elusive
Externí odkaz:
https://doaj.org/article/0219a60f06354a4495a0f6088c161287
Autor:
Katherine L. Mallory, Justin A. Taylor, Xiaoyan Zou, Ishita N. Waghela, Cosette G. Schneider, Michael Q. Sibilo, Neeraja M. Punde, Leah C. Perazzo, Tatyana Savransky, Martha Sedegah, Sheetij Dutta, Chris J. Janse, Norbert Pardi, Paulo J. C. Lin, Ying K. Tam, Drew Weissman, Evelina Angov
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-12 (2021)
Abstract Human malaria affects the vast majority of the world’s population with the Plasmodium falciparum species causing the highest rates of morbidity and mortality. With no licensed vaccine and leading candidates achieving suboptimal protection
Externí odkaz:
https://doaj.org/article/e05bb1dcc8a24bf8950c79ee7ff517fc
Autor:
Rebeca Santano, Rocío Rubio, Berta Grau-Pujol, Valdemiro Escola, Osvaldo Muchisse, Inocência Cuamba, Marta Vidal, Gemma Ruiz-Olalla, Ruth Aguilar, Javier Gandasegui, Maria Demontis, Jose Carlos Jamine, Anélsio Cossa, Charfudin Sacoor, Jorge Cano, Luis Izquierdo, Chetan E Chitnis, Ross L Coppel, Virander Chauhan, David Cavanagh, Sheetij Dutta, Evelina Angov, Lisette van Lieshout, Bin Zhan, José Muñoz, Carlota Dobaño, Gemma Moncunill
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 16, Iss 6, p e0010138 (2022)
BackgroundSoil-transmitted helminths (STH), Schistosoma spp. and Plasmodium falciparum are parasites of major public health importance and co-endemic in many sub-Saharan African countries. Management of these infections requires detection and treatme
Externí odkaz:
https://doaj.org/article/331b78039938433b9edbdb67c9d577ce
Autor:
Merricka C. Livingstone, Alexis A. Bitzer, Alish Giri, Kun Luo, Rajeshwer S. Sankhala, Misook Choe, Xiaoyan Zou, S. Moses Dennison, Yuanzhang Li, William Washington, Viseth Ngauy, Georgia D. Tomaras, M. Gordon Joyce, Adrian H. Batchelor, Sheetij Dutta
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Plasmodium falciparum malaria contributes to a significant global disease burden. Circumsporozoite protein (CSP), the most abundant sporozoite stage antigen, is a prime vaccine candidate. Inhibitory monoclonal antibodies (mAbs) against CSP m
Externí odkaz:
https://doaj.org/article/f735407d93c347bfbd54ca0405a5bab5
Autor:
Nathan Beutler, Tossapol Pholcharee, David Oyen, Yevel Flores-Garcia, Randall S MacGill, Elijah Garcia, Jaeson Calla, Mara Parren, Linlin Yang, Wayne Volkmuth, Emily Locke, Jason A Regules, Sheetij Dutta, Daniel Emerling, Angela M Early, Daniel E Neafsey, Elizabeth A Winzeler, C Richter King, Fidel Zavala, Dennis R Burton, Ian A Wilson, Thomas F Rogers
Publikováno v:
PLoS Pathogens, Vol 18, Iss 3, p e1010409 (2022)
Potent and durable vaccine responses will be required for control of malaria caused by Plasmodium falciparum (Pf). RTS,S/AS01 is the first, and to date, the only vaccine that has demonstrated significant reduction of clinical and severe malaria in en
Externí odkaz:
https://doaj.org/article/466c773f347b462fb6e06036904736dc
Autor:
Arasu Balasubramaniyam, Emma Ryan, Dallas Brown, Therwa Hamza, William Harrison, Michael Gan, Rajeshwer S. Sankhala, Wei-Hung Chen, Elizabeth J. Martinez, Jaime L. Jensen, Vincent Dussupt, Letzibeth Mendez-Rivera, Sandra Mayer, Jocelyn King, Nelson L. Michael, Jason Regules, Shelly Krebs, Mangala Rao, Gary R. Matyas, M. Gordon Joyce, Adrian H. Batchelor, Gregory D. Gromowski, Sheetij Dutta
Publikováno v:
Vaccines, Vol 11, Iss 1, p 42 (2022)
The emergence of novel potentially pandemic pathogens necessitates the rapid manufacture and deployment of effective, stable, and locally manufacturable vaccines on a global scale. In this study, the ability of the Escherichia coli expression system
Externí odkaz:
https://doaj.org/article/ae04c64ff0bf418ea904130036569eac
Autor:
Gemma Moncunill, Jason Carnes, William Chad Young, Lindsay Carpp, Stephen De Rosa, Joseph J Campo, Augusto Nhabomba, Maxmillian Mpina, Chenjerai Jairoce, Greg Finak, Paige Haas, Carl Muriel, Phu Van, Héctor Sanz, Sheetij Dutta, Benjamin Mordmüller, Selidji T Agnandji, Núria Díez-Padrisa, Nana Aba Williams, John J Aponte, Clarissa Valim, Daniel E Neafsey, Claudia Daubenberger, M Juliana McElrath, Carlota Dobaño, Ken Stuart, Raphael Gottardo
Publikováno v:
eLife, Vol 11 (2022)
Background: In a phase 3 trial in African infants and children, the RTS,S/AS01 vaccine (GSK) showed moderate efficacy against clinical malaria. We sought to further understand RTS,S/AS01-induced immune responses associated with vaccine protection. Me
Externí odkaz:
https://doaj.org/article/37c360e9cf6d4232954aa26b5b65805e