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HIV‐1 infection of CD4 T cells impairs antigen‐specific B cell function

Autor: Katharina Morath, Florian Klein, Sheetal Kaw, Bahar M Coban, Oliver T. Fackler, Ralph Hohenberger, Olcay Cem Bulut, Bettina Stolp, Swetha Ananth, Nikolaos Tsopoulidis

Publikováno v: The EMBO Journal

Failures to produce neutralizing antibodies upon HIV‐1 infection result in part from B‐cell dysfunction due to unspecific B‐cell activation. How HIV‐1 affects antigen‐specific B‐cell functions remains elusive. Using an adoptive transfer m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9494197cdd4802c5540227ce0f5e82c
http://europepmc.org/articles/PMC7737609

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HIV-1 Nef Disrupts CD4+ T Lymphocyte Polarity, Extravasation, and Homing to Lymph Nodes via Its Nef-Associated Kinase Complex Interface

Autor: Sakshi Arora, Birthe Trautz, Nikolaos Tsopoulidis, Jingxia Wu, Bettina Stolp, Guoliang Cui, Motomu Tanaka, Oliver T. Fackler, Nadine Tibroni, Ruth Lyck, Ina Ambiel, Jens V. Stein, Judith Thoma, Tatjana Reif, Miguel Lamas-Murua, Andrea Imle, Sheetal Kaw

Publikováno v: The Journal of Immunology. 201:2731-2743

HIV-1 Nef is a multifunctional protein that optimizes virus spread and promotes immune evasion of infected cells to accelerate disease progression in AIDS patients. As one of its activities, Nef reduces the motility of infected CD4+ T lymphocytes in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8aaadbd3787a95e4430a2aa6f1dda6c6
https://doi.org/10.4049/jimmunol.1701420

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T cell receptor–triggered nuclear actin network formation drives CD4 + T cell effector functions

Autor: Oliver T. Fackler, Bettina Stolp, Robert Grosse, Nikolaos Tsopoulidis, Vibor Laketa, C. Baarlink, Sheetal Kaw, Stefan Kutscheidt

Publikováno v: Science Immunology. 4

T cell antigen receptor (TCR) signaling triggers selective cytokine expression to drive T cell proliferation and differentiation required for immune defense and surveillance. The nuclear signaling events responsible for specificity in cytokine gene e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c988e679f385ee4438a3b2bc25b1fbce
https://doi.org/10.1126/sciimmunol.aav1987

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HIV-1 Nef Disrupts CD4

Autor: Miguel, Lamas-Murua, Bettina, Stolp, Sheetal, Kaw, Judith, Thoma, Nikolaos, Tsopoulidis, Birthe, Trautz, Ina, Ambiel, Tatjana, Reif, Sakshi, Arora, Andrea, Imle, Nadine, Tibroni, Jingxia, Wu, Guoliang, Cui, Jens V, Stein, Motomu, Tanaka, Ruth, Lyck, Oliver T, Fackler

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 201(9)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::40e63d51f9f7afb774eb8f84cc943c10
https://pubmed.ncbi.nlm.nih.gov/30257886

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Constitutive CD40 Signaling Calibrates Differentiation Outcomes in Responding B Cells via Multiple Molecular Pathways

Autor: Satyajit Rath, Anna George, Tushar Vaidya, Lucas D’Souza, Vineeta Bal, Srijani Basu, Sheetal Kaw

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 197(3)

CD40 signaling during B cell activation is known to inhibit terminal differentiation and promote memory generation. Blimp-1 is essential for efficient plasma cell (PC) generation, and although CD40 signaling is known to inhibit Blimp-1 induction duri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bf29158236346b7492e14ddc5f0f5e1
https://pubmed.ncbi.nlm.nih.gov/27342845

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Inhibition of Terminal Differentiation of B Cells Mediated by CD27 and CD40 Involves Signaling through JNK

Autor: Sheetal Kaw, Gautam N Shenoy, Tushar Vaidya, Vineeta Bal, Shuchismita R. Satpathy, Anna George, Satyajit Rath

Publikováno v: The Journal of Immunology. 185:6499-6507

B cells responding to cognate Ag in vivo undergo clonal expansion that is followed by differentiation into Ab-secreting plasma cells or into quiescent restimulable memory. Both these events occur in the germinal center and require that cells exit fro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9784e3afbe8252aec3ccb19891537e54
https://doi.org/10.4049/jimmunol.0903229

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Recruitment of memory B cells to lymph nodes remote from the site of immunization requires an inflammatory stimulus

Autor: Sheetal Kaw, Priyadarshini Chatterjee, Snigdha Mukherjee, Deepak K. Rathore, Gautam N Shenoy, Satyajit Rath, Vineeta Bal, Anna George

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 189(2)

Successful recall Ab responses require recruitment of quiescent memory B cells to secondary lymphoid organs. However, the cellular dynamics of memory cells responding to local antigenic challenge at lymphoid sites distal from the initial Ag encounter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c245063d1138443e69dbb7b6b6b08d5
https://pubmed.ncbi.nlm.nih.gov/22675203

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Abstract 64: Targeting immune checkpoints: using a big data approach for their identification, prioritization and application

Autor: Sanatan Upmanyu, Sheetal Kaw, Krishnan Nandabalan, Himani Sharma

Publikováno v: Cancer Research. 75:64-64

Tumor cells have long been known to successfully evade immune surveillance mechanisms.In order to curtail the tumor progression as well as to develop effective therapeutic anti-tumor strategies, key immune regulators,or so-called immune checkpoints,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c1a8ab199582592a3e94907f4966a9a2
https://doi.org/10.1158/1538-7445.am2015-64

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