Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Sheera Rosenbaum"'
Autor:
Claudia Capparelli, Timothy J. Purwin, McKenna Glasheen, Signe Caksa, Manoela Tiago, Nicole Wilski, Danielle Pomante, Sheera Rosenbaum, Mai Q. Nguyen, Weijia Cai, Janusz Franco-Barraza, Richard Zheng, Gaurav Kumar, Inna Chervoneva, Ayako Shimada, Vito W. Rebecca, Adam E. Snook, Kim Hookim, Xiaowei Xu, Edna Cukierman, Meenhard Herlyn, Andrew E. Aplin
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Mechanisms underlying tumor cell plasticity remain poorly understood. Here, the authors show the presence of a dormant-invasive SOX10- subpopulation in cutaneous melanoma that can be targeted by cIAP1/2 inhibitors.
Externí odkaz:
https://doaj.org/article/59cac3fded2d4f39825e28a5697d2477
Autor:
Andrew E. Aplin, Yosef Yarden, Iman Osman, Yulius Y. Setiady, Michael A. Davies, Scott E. Woodman, Jason Roszik, Inna Chervoneva, Tingting Zhan, Nadège Gaborit, Amel Salhi, Lisa D. Berman-Booty, Sheera Rosenbaum, Claudia Capparelli
Supplementary Figures S1-6 Supplemental Fig. S1. ErbB3 and ErbB4 expression in melanoma cell lines. Supplemental Fig. S2. Depletion of NRG1 inhibits ErbB3 downstream signaling and cell growth in WT/WT melanoma cell lines. Supplemental Fig. S3. Deplet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32c90428815a8a988c703abe3efe07f3
https://doi.org/10.1158/0008-5472.22405496
https://doi.org/10.1158/0008-5472.22405496
Autor:
Andrew E. Aplin, Yosef Yarden, Iman Osman, Yulius Y. Setiady, Michael A. Davies, Scott E. Woodman, Jason Roszik, Inna Chervoneva, Tingting Zhan, Nadège Gaborit, Amel Salhi, Lisa D. Berman-Booty, Sheera Rosenbaum, Claudia Capparelli
Supplemental Methods and Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cd1844c5b413bde8cc00e70e6342a5b
https://doi.org/10.1158/0008-5472.22405499
https://doi.org/10.1158/0008-5472.22405499
Autor:
Manoela Tiago, Timothy J. Purwin, Mitchell E. Fane, Yash Chhabra, Jessica L. F. Teh, Rama Kadamb, Weijia Cai, Inna Chervoneva, Sheera Rosenbaum, Vivian Chua, Nir Hacohen, Michael A. Davies, Jessie Villanieva, Ashani T. Weeraratna, Claudia Capparelli, Julio A. Aguirre-Ghiso, Andrew E. Aplin
Publikováno v:
Cancer Research. 83:A005-A005
Despite the clinical success of targeted inhibitors, tumor responses to these agents are transient, and drug-tolerant residual cells seed resistance. Understanding the role of tumor-intrinsic mechanisms and effects of the tumor microenvironment in me
Autor:
Dan A. Erkes, Andrew E. Aplin, Sheera Rosenbaum, Conroy O. Field, Inna Chervoneva, Jessie Villanueva
Publikováno v:
Pigment Cell Melanoma Res
Bromodomain and extra terminal inhibitors (BETi) delay tumor growth, in part, through tumor cell intrinsic alterations and initiation of anti-tumor CD8+ T cell responses. By contrast, BETi effects on pro-tumoral immune responses remain unclear. Here,
Autor:
Claudia, Capparelli, Timothy J, Purwin, McKenna, Glasheen, Signe, Caksa, Manoela, Tiago, Nicole, Wilski, Danielle, Pomante, Sheera, Rosenbaum, Mai Q, Nguyen, Weijia, Cai, Janusz, Franco-Barraza, Richard, Zheng, Gaurav, Kumar, Inna, Chervoneva, Ayako, Shimada, Vito W, Rebecca, Adam E, Snook, Kim, Hookim, Xiaowei, Xu, Edna, Cukierman, Meenhard, Herlyn, Andrew E, Aplin
Publikováno v:
Nature communications. 13(1)
Cellular plasticity contributes to intra-tumoral heterogeneity and phenotype switching, which enable adaptation to metastatic microenvironments and resistance to therapies. Mechanisms underlying tumor cell plasticity remain poorly understood. SOX10,
Publikováno v:
Cancer Discov
Unleashing the immune system with immune checkpoint inhibitors (ICI) has significantly improved overall survival for subsets of patients with stage III/IV cancer. However, many tumors are nonresponsive to ICIs, in part due to a lack of tumor-infiltra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47975f38ee4c0cd29ac670d16fe8eb18
https://europepmc.org/articles/PMC7858229/
https://europepmc.org/articles/PMC7858229/
Autor:
Weijia Cai, Adam E. Snook, McKenna Glasheen, Inna Chervoneva, Sheera Rosenbaum, Ayako Shimada, Mai Q. Nguyen, Andrew E. Aplin, Danielle Pomante, Claudia Capparelli, Xiaowei Xu, Manoela Tiago, Kim HooKim, Timothy J. Purwin, Michael A. Davies, Meenhard Herlyn, Edna Cukierman, Gaurav Kumar, Nicole A. Wilski, Richard Zheng, Paolo Fortina
Publikováno v:
Cancer Research. 81:40-40
Intratumoral heterogeneity and cellular plasticity enable tumors to alter phenotypes and adapt to foreign microenvironments and resist targeted inhibitors. While the ability to switch between phenotypic states has been broadly characterized, the key
Autor:
David E. Fisher, Dan A. Erkes, Michael A. Davies, Mehri Mollaee, Jeffrey E. Gershenwald, Inna Chervoneva, Peter A. McCue, Meghan Knecht, Sheera Rosenbaum, Timothy J. Purwin, Jennifer A. Lo, Zhijiu Zhong, Adam C. Berger, Andrew E. Aplin
Publikováno v:
Cell reports
Cell Reports, Vol 30, Iss 2, Pp 510-524.e6 (2020)
Cell Reports, Vol 30, Iss 2, Pp 510-524.e6 (2020)
SUMMARY Immune checkpoint inhibitors have improved patient survival in melanoma, but the innate resistance of many patients necessitates the investigation of alternative immune targets. Many immune checkpoint proteins lack proper characterization, in
Autor:
Curtis H. Kugel, Timothy J. Purwin, Manoela Tiago, Sheera Rosenbaum, Shea A. Heilman, Andrew E. Aplin, Edward J. Hartsough, Inna Chervoneva, Michele B. Weiss, Dan A. Erkes, Kim HooKim
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 10, Iss 4, Pp 1-15 (2019)
Cell Death and Disease, Vol 10, Iss 4, Pp 1-15 (2019)
Metastatic cancer remains a clinical challenge; however, patients diagnosed prior to metastatic dissemination have a good prognosis. The transcription factor, TWIST1 has been implicated in enhancing the migration and invasion steps within the metasta