Transcriptomic diversity in human medullary thymic epithelial cells

Autor: Jason A. Carter, Léonie Strömich, Matthew Peacey, Sarah R. Chapin, Lars Velten, Lars M. Steinmetz, Benedikt Brors, Sheena Pinto, Hannah V. Meyer

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)

The thymus generates all T cells, including those that underly autoimmune diseases. Here, using deep sequencing, the authors profile human medullary thymic epithelial cells and establish a web portal to query their transcriptome, which may serve as a

Externí odkaz: https://doaj.org/article/cd8d5709b0484a3e9ece600be3ca2e46

894 The bispecific innate cell engagers AFM13 (CD30/CD16A) and AFM24 (EGFR/CD16A) increase the fraction of tumor target-responsive NK cells and boost serial killing

Autor: Joachim Koch, Sheena Pinto, Susanne Wingert, Jens Pahl, Chiara Zambarda, Karolin Guldevall, Christian Breunig, Damien Toullec, Jacopo Fontana, Björn Önfelt

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)

Externí odkaz: https://doaj.org/article/dde28aa9a42d4f86ae8c60c460702adf

Abstract 2950: CD16A shedding facilitates repetitive targeting of tumor cells by AFM13-armed NK cells

Autor: Chiara Zambarda, Karolin Guldevall, Damien Toullec, Susanne Wingert, Christian Breunig, Sheena Pinto, Jacopo Fontana, Joachim Koch, Björn Önfelt

Publikováno v: Cancer Research. 83:2950-2950

Antibody-Dependent Cellular Cytotoxicity (ADCC) is a powerful mechanism of Natural Killer (NK) cells to kill antibody-opsonized target cells. However, ADCC mediated by conventional antibodies has its limitations in killing of tumor cells commonly bei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a5c967aa78638a79869ea249df06bc03
https://doi.org/10.1158/1538-7445.am2023-2950

CD8+ T Cells Variably Recognize Native versus Citrullinated GRP78 Epitopes in Type 1 Diabetes

Autor: Maki Nakayama, Maikel Luis Colli, Yann Verdier, Noemi Brusco, Lut Overbergh, Mark J. Mamula, Aïsha Callebaut, Joëlle Vinh, Guido Sebastiani, Georgia Afonso, Laura Nigi, Matthieu Giraud, Barbara Brandao, Zhicheng Zhou, Sylvaine You, Alexia Carré, Mijke Buitinga, Sheena Pinto, Marie Eliane Azoury, Decio L. Eizirik, Francesco Dotta, Chantal Mathieu, Søren Buus, Roberto Mallone, Fatoumata Samassa, Ana Ines Lalanne, Magali Irla

Publikováno v: Diabetes
Diabetes, American Diabetes Association, 2021, pp.db210259. ⟨10.2337/db21-0259⟩

In type 1 diabetes, autoimmune β-cell destruction may be favored by neo-antigens harboring post-translational modifications such as citrullination. We studied the recognition of native and citrullinated glucose-regulated protein (GRP)78 peptides by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a38375b241b82cebe35b607398e6eea
https://doi.org/10.2337/figshare.16654669

Peptides Derived From Insulin Granule Proteins Are Targeted by CD8 + T Cells Across MHC Class I Restrictions in Humans and NOD Mice

Autor: Joëlle Vinh, Aurore Pais, Sylvaine You, Etienne Larger, Decio L. Eizirik, Maikel Luis Colli, Laure Alexandre-Heymann, Danièle Dubois-Laforgue, Roberto Mallone, Søren Buus, Georgia Afonso, Graziella Bruno, Mahmoud Tarayrah, Cassandra Lavaud, Gonzalez-Duque Sergio, Jean-Paul Beressi, Sheena Pinto, Marie Eliane Azoury, Claire Maillard, Verdier Yann

Publikováno v: Diabetes
Diabetes, 2020, 69 (12), pp.2678-2690. ⟨10.2337/db20-0013⟩
Diabetes, American Diabetes Association, 2020, 69 (12), pp.2678-2690. ⟨10.2337/db20-0013⟩

The antigenic peptides processed by β cells and presented through surface HLA Class I molecules are poorly characterized. Each HLA variant, e.g. the most common HLA-A2 and HLA-A3, carries some peptide-binding specificity. Hence, features that, despi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c1a19452588c10d10f72a2c18829d5e
https://www.hal.inserm.fr/inserm-03312401