Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Sheena M. Daignault"'
Autor:
Heike Chauvistré, Batool Shannan, Sheena M. Daignault-Mill, Robert J. Ju, Daniel Picard, Stefanie Egetemaier, Renáta Váraljai, Christine S. Gibhardt, Antonio Sechi, Farnusch Kaschani, Oliver Keminer, Samantha J. Stehbens, Qin Liu, Xiangfan Yin, Kirujan Jeyakumar, Felix C. E. Vogel, Clemens Krepler, Vito W. Rebecca, Linda Kubat, Smiths S. Lueong, Jan Forster, Susanne Horn, Marc Remke, Michael Ehrmann, Annette Paschen, Jürgen C. Becker, Iris Helfrich, Daniel Rauh, Markus Kaiser, Sheraz Gul, Meenhard Herlyn, Ivan Bogeski, José Neptuno Rodríguez-López, Nikolas K. Haass, Dirk Schadendorf, Alexander Roesch
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Slow-cycling melanoma persister cells are characterised by a high, reversible expression of H3K4 demethylase KDM5B. Here, the authors use genetic and chemical methods to enforce a permanent high expression of KDM5B and show that these cells transit t
Externí odkaz:
https://doaj.org/article/37bb3c7c6ed14e8aa7ac035cb7135585
Autor:
Zay Yar Oo, Martina Proctor, Alexander J. Stevenson, Deborah Nazareth, Madushan Fernando, Sheena M. Daignault, Catherine Lanagan, Sebastian Walpole, Vanessa Bonazzi, Dubravka Škalamera, Cameron Snell, Nikolas K. Haass, Jill E. Larsen, Brian Gabrielli
Publikováno v:
Molecular Oncology, Vol 13, Iss 7, Pp 1503-1518 (2019)
Drugs such as gemcitabine that increase replication stress are effective chemotherapeutics in a range of cancer settings. These drugs effectively block replication and promote DNA damage, triggering a cell cycle checkpoint response through the ATR–
Externí odkaz:
https://doaj.org/article/f030e16cdb874773a4afb382b8266e37
Autor:
Brian Gabrielli, Nikolas K. Haass, Richard A. Sturm, Stephen A. Ainger, Loredana Spoerri, Dubravka Škalamera, James Chen, Catherine Lanagan, Sebastian Walpole, Sheena M. Daignault, Martina Proctor, Alexander J. Stevenson, Zay Yar Oo
Purpose: Checkpoint kinase 1 inhibitors (CHEK1i) have single-agent activity in vitro and in vivo. Here, we have investigated the molecular basis of this activity.Experimental Design: We have assessed a panel of melanoma cell lines for their sensitivi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b2d500d668d42bc11bf309dc19b22bf
https://doi.org/10.1158/1078-0432.c.6525843
https://doi.org/10.1158/1078-0432.c.6525843
Autor:
Brian Gabrielli, Nikolas K. Haass, Richard A. Sturm, Stephen A. Ainger, Loredana Spoerri, Dubravka Škalamera, James Chen, Catherine Lanagan, Sebastian Walpole, Sheena M. Daignault, Martina Proctor, Alexander J. Stevenson, Zay Yar Oo
Supplementary Figures and Table
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14997ccfd8ebcf17aa986b152fa534c5
https://doi.org/10.1158/1078-0432.22464873
https://doi.org/10.1158/1078-0432.22464873
Autor:
Ethan K. Scott, Samantha J. Stehbens, Jagat Chauhan, Aaron G. Smith, Glen M. Boyle, David S. Hill, Colin R. Goding, Russell J Jurek, Sheena M. Daignault-Mill, Mitchell Fane, Gency Gunasingh, Brian Gabrielli, Nicholas Matigian, Wolfgang Weninger, Kimberley A. Beaumont, Gilles Vanwalleghem, Crystal A Tonnessen-Murray, Loredana Spoerri, Helmut Schaider, Nikolas K. Haass
Phenotypic heterogeneity of cancer cells plays a critical role in shaping treatment response. This type of heterogeneity is organized spatially with specific phenotypes, such as sharply demarcated clusters of proliferating and cell cycle-arrested cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::830ac02b4104d8d31185d81d0ffb827f
https://doi.org/10.1101/2020.06.09.141747
https://doi.org/10.1101/2020.06.09.141747