The acyl-CoA synthetase TgACS1 allows neutral lipid metabolism and extracellular motility in Toxoplasma gondii through relocation via its peroxisomal targeting sequence (PTS) under low nutrient conditions

Autor: Sarah Charital, Serena Shunmugam, Sheena Dass, Anna Maria Alazzi, Christophe-Sébastien Arnold, Nicholas J. Katris, Samuel Duley, Nyamekye A. Quansah, Fabien Pierrel, Jérôme Govin, Yoshiki Yamaryo-Botté, Cyrille Y. Botté

Publikováno v: mBio, Vol 15, Iss 4 (2024)

ABSTRACTApicomplexa parasites cause major diseases such as toxoplasmosis and malaria that have major health and economic burdens. These unicellular pathogens are obligate intracellular parasites that heavily depend on lipid metabolism for the surviva

Externí odkaz: https://doaj.org/article/9417f62639aa4f78aae0a9672dc9d200

Development of a Plasmodium vivax biobank for functional ex vivo assays

Autor: Rashmi Dash, Kristen M. Skillman, Ligia Pereira, Anjali Mascarenhas, Sheena Dass, Jayashri Walke, Anvily Almeida, Mezia Fernandes, Edwin Gomes, John White, Laura Chery-Karschney, Anar Khandeparkar, Pradipsinh K. Rathod, Manoj T. Duraisingh, Usheer Kanjee

Publikováno v: Malaria Journal, Vol 22, Iss 1, Pp 1-10 (2023)

Abstract Background Plasmodium vivax is the second most prevalent cause of malaria yet remains challenging to study due to the lack of a continuous in vitro culture system, highlighting the need to establish a biobank of clinical isolates with multip

Externí odkaz: https://doaj.org/article/bb5a53c8e3014dd7b277b32f277d6af7

The flexibility of Apicomplexa parasites in lipid metabolism

Autor: Serena Shunmugam, Christophe-Sébastien Arnold, Sheena Dass, Nicholas J. Katris, Cyrille Y. Botté

Publikováno v: PLoS Pathogens, Vol 18, Iss 3 (2022)

Apicomplexa are obligate intracellular parasites responsible for major human infectious diseases such as toxoplasmosis and malaria, which pose social and economic burdens around the world. To survive and propagate, these parasites need to acquire a s

Externí odkaz: https://doaj.org/article/787a86baeae14caabd0069143a211caf

Toxoplasma gondii acetyl-CoA synthetase is involved in fatty acid elongation (of long fatty acid chains) during tachyzoite life stages

Autor: David Dubois, Stella Fernandes, Souad Amiar, Sheena Dass, Nicholas J. Katris, Cyrille Y. Botté, Yoshiki Yamaryo-Botté

Publikováno v: Journal of Lipid Research, Vol 59, Iss 6, Pp 994-1004 (2018)

Apicomplexan parasites are pathogens responsible for major human diseases such as toxoplasmosis caused by Toxoplasma gondii and malaria caused by Plasmodium spp. Throughout their intracellular division cycle, the parasites require vast and specific a

Externí odkaz: https://doaj.org/article/07994758a30f479cb4d0c1f27c451a47

Division and Adaptation to Host Environment of Apicomplexan Parasites Depend on Apicoplast Lipid Metabolic Plasticity and Host Organelle Remodeling

Autor: Melanie J. Shears, Souad Amiar, Samuel Duley, Laurence Berry, Sheena Dass, Yoshiki Yamaryo-Botté, Bastien Touquet, Nicholas J. Katris, Cyrille Y. Botté, Geoffrey I. McFadden, Camille Dorothée Brunet, Christophe-Sébastien Arnold

Publikováno v: Cell Reports
Cell Reports, Elsevier Inc, 2020, 30 (11), pp.3778-3792.e9. ⟨10.1016/j.celrep.2020.02.072⟩
Cell Reports, Vol 30, Iss 11, Pp 3778-3792.e9 (2020)

Summary: Apicomplexan parasites are unicellular eukaryotic pathogens that must obtain and combine lipids from both host cell scavenging and de novo synthesis to maintain parasite propagation and survival within their human host. Major questions on th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66c6e53172a6a08f7d30f830afe4d566
https://hal.archives-ouvertes.fr/hal-03103818