Výsledky vyhledávání - "Sheela Karunanithi"

Chemical screening identifies novel small molecule activators of Natural Killer cell cytotoxicity against cancer cells

Autor: Sheela Karunanithi, Huaiyu Wang, Zachary Jackson, Grace Lee, Hong Cheng, Bruce A. Posner, Yuriy Federov, Karam Musaitif, Hanspeter Niederstrasser, David N. Wald, Shivaprasad Manjappa

Publikováno v: Cancer Immunol Immunother

Natural killer (NK) cells are cytotoxic lymphocytes that play a major role in the innate immune system. NK cells exhibit potent cytotoxic activity against cancer cells and virally infected cells without antigen priming. These unique cytotoxic propert

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2a3d90aed21988f019d3e0f335cc701
https://europepmc.org/articles/PMC9124724/

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Abstract 4080: New platform for novel biomarker discovery using single-cell RNA sequencing on pediatric acute myeloid leukemia samples

Autor: Robert Schauner, Zachary Jackson, Nethrie Idippily, Grace Lee, Sheela Karunanithi, Shivaprasaad Manjappa, Tae Hyun Hwang, David Wald

Publikováno v: Cancer Research. 82:4080-4080

Pediatric Acute Myeloid Leukemia (AML) with a FLT3 internal tandem duplication (FLT3-ITD) is a challenging disease due to poor outcomes in many patients. The 4-year progression-free survival is still only 31%. Current biomarkers are insufficient to p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e3420b7daa68727a5eda79343d842ac4
https://doi.org/10.1158/1538-7445.am2022-4080

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A Securinine Derivative as a Novel Treatment for Acute Myeloid Leukemia

Autor: Grace S. Lee, Stephen Moreton, Natasha Oldford, Lindsay Stetson, Youngchun Hou, Juan Valentin Goyco, Ruifu Liu, David N. Wald, Sheela Karunanithi, Anne Roe

Publikováno v: The FASEB Journal. 33

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7a3c0d8f599cc80404b89d84f06c6259
https://doi.org/10.1096/fasebj.2019.33.1_supplement.lb224

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Small Molecule Screening Identifies Rho-Associate Protein Kinase (ROCK) As a Regulator of NK Cell Cytotoxicity Against Cancer

Autor: Sheela Karunanithi, Zachary Jackson, Grace Lee, David N. Wald

Publikováno v: Blood. 134:3607-3607

NK cells are a subset of lymphocytes that directly recognize and lyse tumor cells without the limitation of antigen specific receptor recognition. In addition to behaving as cytotoxic effector cells, NK cells unlike T cells are not thought to elicit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::71922988cf65b28265a17f53c1cf7385
https://doi.org/10.1182/blood-2019-131947

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Abstract 382: Inhibition of mitochondrial spare respiratory capacity by new securinine derivatives as a novel differentiation therapy for acute myeloid leukemia

Autor: Yongchun Hou, David N. Wald, Anne Roe, Juan Valentin Goyco, Ruifu Liu, Sheela Karunanithi, Natasha Oldford, Stephen Moreton

Publikováno v: Cancer Research. 78:382-382

Acute myeloid leukemia (AML) is characterized by a differentiation block in myeloid progenitors resulting in aberrant proliferation of immature myeloid cells. Therapeutics that induce differentiation of leukemic cells would overcome the high toxicity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4801ed1a1b619a45346edb3794e0bb0a
https://doi.org/10.1158/1538-7445.am2018-382

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