Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Sheela Bhattacharjee"'
Autor:
Sheela Bhattacharjee, Allan George, Scott G. Lundeen, Olivia Linton, Pamela Tannenbaum, Xuqing Zhang, Donna Haynes-Johnson, Tifanie Sbriscia, Zhihua Sui, Muh-Tsann Lai
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 134:51-58
Selective androgen receptor modulators (SARMs) are androgens with tissue-selective activity. SARMs that have anabolic activity on muscle while having minimal stimulatory activity on prostate are classified as SARM agonists. They can be used to preven
Autor:
Patricia Kraft, Xuqing Zhang, Scott G. Lundeen, Yuhong Qiu, Morgan Woods, Sheela Bhattacharjee, Xiaojie Li, Zhihua Sui
Publikováno v:
Bioorganic & Medicinal Chemistry. 17:855-866
A novel series of benzopyran derivatives were synthesized and evaluated as KATP channel openers. Structure–activity relationships were investigated around 4-position of the benzopyran nucleus. Optimization of 4-substituent with some heterocyclic ri
Autor:
Zhihua Sui, Raymond A. Ng, Muh-Tsann Lai, Olivia Linton, Scott G. Lundeen, Sheela Bhattacharjee, George F. Allan, Tifanie Sbriscia, Donna Haynes-Johnson
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 110:207-213
Androgens are required for the maintenance of normal sexual activity in adulthood and for enhancing muscle growth and lean body mass in adolescents and adults. Androgen receptor (AR) ligands with tissue selectivity (selective androgen receptor modula
Autor:
Margaret Kiddoe, Olivia Linton, C. Edgar Cook, John A. Kepler, Zhihua Sui, Sheela Bhattacharjee, George F. Allan, Scott G. Lundeen, Chunyang Jin, Govindarajan Manikumar
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:5754-5757
A series of novel 11β-aryl-4′,5′-dihydrospiro[estra-4,9-diene-17β,4′-oxazole] analogs have been evaluated for their antagonist hormonal properties using the T47D cell-based alkaline phosphatase assay and the A549 cell-based functional assay.
Autor:
Olivia Linton, Tifanie Sbriscia, Xuqing Zhang, George F. Allan, Muh-Tsann Lai, Sheela Bhattacharjee, Zhihua Sui, Donna Haynes-Johnson, Scott G. Lundeen, Pamela Tannenbaum
Publikováno v:
Endocrine. 32:41-51
Androgen receptor (AR) ligands with tissue selectivity (selective androgen receptor modulators, or SARMs) have potential for treating muscle wasting, hypogonadism of aging, osteoporosis, female sexual dysfunction, and other indications. JNJ-28330835
JNJ-10280205 and JNJ-10287069: novel PDE5 inhibitors as clinical candidates for erectile dysfunction
Autor:
Zhihua Sui, T. Mathew John, Patricia Kraft, Weiqin Jiang, Sheela Bhattacharjee, Donna Haynes-Johnson, Scott G. Lundeen, Yuhong Qiu
Publikováno v:
International Journal of Impotence Research. 18:477-483
Phosphodiesterase 5 (PDE5) inhibitors are efficacious in treating patients with erectile dysfunction. New PDE5 inhibitors with different selectivity and pharmacokinetic profiles have been vigorously pursued. Here we report two novel, potent, and sele
Autor:
Michael R. D'Andrea, Donna Haynes-Johnson, Scott G. Lundeen, Yuhong Qiu, Patricia Kraft, Sheela Bhattacharjee
Publikováno v:
Journal of Histochemistry & Cytochemistry. 53:895-903
Cyclic nucleotide phosphodiesterase 11A (PDE11A) is the newest member in the PDE family. Although the tissue distribution of PDE11A mRNA has been shown, its protein expression pattern has not been well studied. The goal of this report is to investiga
Autor:
Joanna Clancy, Weiqin Jiang, Elizabeth Craig, Donna Haynes-Johnson, T. Mathew John, Patricia Kraft, Zhihua Sui, Mark J. Macielag, Sheela Bhattacharjee, Jihua Guan, Scott G. Lundeen, Yuhong Qiu
Publikováno v:
European Journal of Pharmacology. 472:73-80
We have characterized a novel, potent, and selective phosphodiesterase type 5 inhibitor, JNJ-10258859 ((R)-(−)-3-(2,3-dihydro-benzofuran-5-yl)-2-[5-(4-methoxy-phenyl)-pyrimidin-2-yl]-1,2,3,4-tetrahydro-pyrrolo[3,4-b]quinolin-9-one). Its inhibitory
Autor:
Weiqin Jiang, Yuhong Qiu, Zhihua Sui, Patricia Kraft, Mark J. Macielag, T. Matthew John, Elizabeth Craig, Joanna Clancy, Sheela Bhattacharjee, Jihua Guan, Donna Haynes-Johnson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:761-765
A series of N(2)-furoyl and N(2)pyrimidinyl beta-carbolines was discovered to possess potent inhibitory activity against PDE5. During the synthesis we developed a tandem resin quenching protocol, which allowed us to synthesize large number of target
Autor:
Yuhong Qiu, Joanna Clancy, Suying Zhang, Patricia Kraft, Sheela Bhattacharjee, Mark J. Macielag, Zhihua Sui, T. Matthew John, Donna Haynes-Johnson, Weiqin Jiang, Jihua Guan
Publikováno v:
Journal of Medicinal Chemistry. 45:4094-4096
A series of N-pyrimidinylpyrroloquinolones were discovered as extremely potent and selective PDE5 inhibitors. Representative compounds demonstrated in vivo efficacy in dog erectile dysfunction models and are orally bioavailable.