Architectural asymmetry enables DNA transport through the Helicobacter pylori cag type IV secretion system.

Autor: Ryan ME; Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky College of Medicine, Lexington, KY, 40506, USA., Damke PP; Department of Veterinary Sciences, University of Kentucky College of Agriculture, Lexington, KY, 40546, USA., Bryant C; Department of Veterinary Sciences, University of Kentucky College of Agriculture, Lexington, KY, 40546, USA., Sheedlo MJ; Department of Pharmacology, University of Minnesota, Minneapolis, MN, 55455, USA., Shaffer CL; Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky College of Medicine, Lexington, KY, 40506, USA.; Department of Veterinary Sciences, University of Kentucky College of Agriculture, Lexington, KY, 40546, USA.; Department of Pharmaceutical Sciences, University of Kentucky College of Pharmacy, Lexington, KY, 40536, USA.; Markey Cancer Center, University of Kentucky College of Medicine, Lexington, KY, 40506, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Jul 26. Date of Electronic Publication: 2023 Jul 26.

Cryo-EM reveals new species-specific proteins and symmetry elements in the Legionella pneumophila Dot/Icm T4SS.

Autor: Sheedlo MJ; Department of Pharmacology, University of Minnesota, Minneapolis, United States.; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, United States., Durie CL; Life Sciences Institute, University of Michigan, Ann Arbor, United States., Chung JM; Life Sciences Institute, University of Michigan, Ann Arbor, United States.; Department of Biotechnology, The Catholic University of Korea, Gyeonggi, Republic of Korea., Chang L; Life Sciences Institute, University of Michigan, Ann Arbor, United States., Roberts J; Life Sciences Institute, University of Michigan, Ann Arbor, United States., Swanson M; Department of Microbiology and Immunology, University Of Michigan, Ann Arbor, United States., Lacy DB; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, United States.; The Veterans Affairs Tennessee Valley Healthcare System, Nasvhille, United States., Ohi MD; Life Sciences Institute, University of Michigan, Ann Arbor, United States.; Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, United States.

Publikováno v: ELife [Elife] 2021 Sep 14; Vol. 10. Date of Electronic Publication: 2021 Sep 14.

Structural analysis of the Legionella pneumophila Dot/Icm type IV secretion system core complex.

Autor: Durie CL; Life Sciences Institute, University of Michigan, Ann Arbor, United States., Sheedlo MJ; Department of Pathology, Microbiology, and Immunology, Department of Pathology, Vanderbilt University Medical Center, Nashville, United States., Chung JM; Life Sciences Institute, University of Michigan, Ann Arbor, United States., Byrne BG; Department of Microbiology and Immunology, University of Michigan, Ann Arbor, United States., Su M; Life Sciences Institute, University of Michigan, Ann Arbor, United States., Knight T; Department of Microbiology and Immunology, University of Michigan, Ann Arbor, United States., Swanson M; Department of Microbiology and Immunology, University of Michigan, Ann Arbor, United States., Lacy DB; Department of Pathology, Microbiology, and Immunology, Department of Pathology, Vanderbilt University Medical Center, Nashville, United States.; The Veterans Affairs Tennessee Valley Healthcare System, Nashville, United States.; Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, United States., Ohi MD; Life Sciences Institute, University of Michigan, Ann Arbor, United States.

Publikováno v: ELife [Elife] 2020 Sep 02; Vol. 9. Date of Electronic Publication: 2020 Sep 02.

Clostridioides difficile infection damages colonic stem cells via TcdB, impairing epithelial repair and recovery from disease.

Autor: Mileto SJ; Infection and Immunity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.; Department of Microbiology, Monash University, Clayton, VIC 3800, Australia., Jardé T; Development and Stem Cells Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.; Department of Anatomy and Developmental Biology, Monash University, Clayton, VIC 3800, Australia.; Centre for Cancer Research, Hudson Institute of Medical Research, Clayton, VIC 3168, Australia., Childress KO; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232., Jensen JL; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232., Rogers AP; Infection and Immunity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.; Department of Microbiology, Monash University, Clayton, VIC 3800, Australia., Kerr G; Development and Stem Cells Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.; Department of Anatomy and Developmental Biology, Monash University, Clayton, VIC 3800, Australia., Hutton ML; Infection and Immunity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.; Department of Microbiology, Monash University, Clayton, VIC 3800, Australia., Sheedlo MJ; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232., Bloch SC; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232., Shupe JA; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232., Horvay K; Development and Stem Cells Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.; Department of Anatomy and Developmental Biology, Monash University, Clayton, VIC 3800, Australia., Flores T; Development and Stem Cells Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.; Department of Anatomy and Developmental Biology, Monash University, Clayton, VIC 3800, Australia., Engel R; Development and Stem Cells Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.; Department of Anatomy and Developmental Biology, Monash University, Clayton, VIC 3800, Australia.; Cabrini Monash University Department of Surgery, Cabrini Hospital, Melbourne, VIC 3144, Australia., Wilkins S; Cabrini Monash University Department of Surgery, Cabrini Hospital, Melbourne, VIC 3144, Australia.; Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, VIC 3004, Australia., McMurrick PJ; Cabrini Monash University Department of Surgery, Cabrini Hospital, Melbourne, VIC 3144, Australia., Lacy DB; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232; borden.lacy@vanderbilt.edu helen.abud@monash.edu dena.lyras@monash.edu.; The Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN 37232., Abud HE; Development and Stem Cells Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia; borden.lacy@vanderbilt.edu helen.abud@monash.edu dena.lyras@monash.edu.; Department of Anatomy and Developmental Biology, Monash University, Clayton, VIC 3800, Australia.; Cabrini Monash University Department of Surgery, Cabrini Hospital, Melbourne, VIC 3144, Australia.; Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, VIC 3004, Australia., Lyras D; Infection and Immunity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia; borden.lacy@vanderbilt.edu helen.abud@monash.edu dena.lyras@monash.edu.; Department of Microbiology, Monash University, Clayton, VIC 3800, Australia.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Apr 07; Vol. 117 (14), pp. 8064-8073. Date of Electronic Publication: 2020 Mar 20.

Structural insights into the transition of Clostridioides difficile binary toxin from prepore to pore.

Autor: Anderson DM; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.; The Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN, USA., Sheedlo MJ; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.; The Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN, USA., Jensen JL; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA., Lacy DB; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA. borden.lacy@vanderbilt.edu.; The Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN, USA. borden.lacy@vanderbilt.edu.

Publikováno v: Nature microbiology [Nat Microbiol] 2020 Jan; Vol. 5 (1), pp. 102-107. Date of Electronic Publication: 2019 Nov 11.