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Assessment of Macro- and Microheterogeneity of Monoclonal Antibodies Using Capillary Zone Electrophoresis Hyphenated with Mass Spectrometry

Autor: Gstöttner, Christoph, Haselberg, Rob, Wuhrer, Manfred, Somsen, Govert W., Domínguez-Vega, Elena, Neusüß, Christian, Jooß, Kevin

Publikováno v: Capillary Electrophoresis-Mass Spectrometry ISBN: 9781071624920
Capillary Electrophoresis-Mass Spectrometry: Methods and Protocols, 125-142
STARTPAGE=125;ENDPAGE=142;TITLE=Capillary Electrophoresis-Mass Spectrometry
Gstöttner, C, Haselberg, R, Wuhrer, M, Somsen, G W & Domínguez-Vega, E 2022, Assessment of Macro-and Microheterogeneity of Monoclonal Antibodies Using Capillary Zone Electrophoresis Hyphenated with Mass Spectrometry . in C Neusüß & K Jooß (eds), Capillary Electrophoresis-Mass Spectrometry : Methods and Protocols . Methods in Molecular Biology, vol. 2531, Humana Press Inc, pp. 125-142 . https://doi.org/10.1007/978-1-0716-2493-7_9

This chapter focuses on the application of capillary zone electrophoresis hyphenated with mass spectrometry (CZE-MS) for the characterization of monoclonal antibodies (mAbs). mAbs are complex molecules comprising different glycoforms and many other p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b4092d5537759e320d350dc2ca8088b
https://doi.org/10.1007/978-1-0716-2493-7_9

CE-MS for metabolomics: advancing performance and detection sensitivity

Autor: Zhang, W.

Publikováno v: None

The major and ultimate aim of metabolomics is to obtain an answer to a specific biological or clinical question. For that, many strategies have been applied in this field, including NMR and MS-based approaches. CE-MS is one of the techniques in this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::0ae90d5438a7a0e6e58195da7d452753
https://hdl.handle.net/1887/87241

Utility of sheathless capillary electrophoresis-mass spectrometry for metabolic profiling of limited sample amounts

Autor: Rawi Ramautar, Wei Zhang, Thomas Hankemeier, Faisa Guled

Publikováno v: Journal of Chromatography B, 1105, 10-14

Metabolomics studies using a small amount of cells may save time and money, while in some cases (e.g., profiling pathogenic cells in an early-stage tissue), only a small number of cells are accessible for analysis. The analysis of small amounts of bi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26b9fb0a551771337a8377fcf4760a82
https://hdl.handle.net/1887/70472

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