A ubiquitous mobile genetic element changes the antagonistic weaponry of a human gut symbiont.

Autor: Sheahan ML; Duchossois Family Institute, University of Chicago, Chicago, IL, USA.; Department of Microbiology, University of Chicago, Chicago, IL, USA., Flores K; Duchossois Family Institute, University of Chicago, Chicago, IL, USA.; Department of Microbiology, University of Chicago, Chicago, IL, USA., Coyne MJ; Duchossois Family Institute, University of Chicago, Chicago, IL, USA.; Department of Microbiology, University of Chicago, Chicago, IL, USA.; Division of Infectious Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., García-Bayona L; Duchossois Family Institute, University of Chicago, Chicago, IL, USA.; Department of Microbiology, University of Chicago, Chicago, IL, USA.; Division of Infectious Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Chatzidaki-Livanis M; Division of Infectious Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Holst AQ; Division of Infectious Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; National Food Institute, Technical University of Denmark, Lyngby, Denmark., Smith RC; Duchossois Family Institute, University of Chicago, Chicago, IL, USA., Sundararajan A; Duchossois Family Institute, University of Chicago, Chicago, IL, USA., Barquera B; Department of Biological Sciences, Rensselaer Polytechnic Institute, Troy, NY, USA.; Department of Chemistry and Chemical Biology, Rensselaer Polytechnic Institute, Troy, NY, USA.; Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, USA., Comstock LE; Duchossois Family Institute, University of Chicago, Chicago, IL, USA.; Department of Microbiology, University of Chicago, Chicago, IL, USA.; Division of Infectious Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Publikováno v: Science (New York, N.Y.) [Science] 2024 Oct 25; Vol. 386 (6720), pp. 414-420. Date of Electronic Publication: 2024 Oct 24.

A cryptic plasmid is among the most numerous genetic elements in the human gut.

Autor: Fogarty EC; Committee on Microbiology, University of Chicago, Chicago, IL 60637, USA; Duchossois Family Institute, University of Chicago, Chicago, IL 60637, USA; Department of Medicine, University of Chicago, Chicago, IL 60637, USA. Electronic address: efogarty@uchicago.edu., Schechter MS; Committee on Microbiology, University of Chicago, Chicago, IL 60637, USA; Duchossois Family Institute, University of Chicago, Chicago, IL 60637, USA; Department of Medicine, University of Chicago, Chicago, IL 60637, USA., Lolans K; Department of Medicine, University of Chicago, Chicago, IL 60637, USA., Sheahan ML; Duchossois Family Institute, University of Chicago, Chicago, IL 60637, USA; Department of Microbiology, University of Chicago, Chicago, IL 60637, USA., Veseli I; Department of Medicine, University of Chicago, Chicago, IL 60637, USA; Graduate Program in Biophysical Sciences, University of Chicago, Chicago, IL 60637, USA., Moore RM; Center for Bioinformatics and Computational Biology, University of Delaware, Newark, DE, USA., Kiefl E; Department of Medicine, University of Chicago, Chicago, IL 60637, USA; Graduate Program in Biophysical Sciences, University of Chicago, Chicago, IL 60637, USA., Moody T; Department of Systems Biology, Columbia University, New York, NY 10032, USA., Rice PA; Committee on Microbiology, University of Chicago, Chicago, IL 60637, USA; Department of Biochemistry, University of Chicago, Chicago, IL 60637, USA., Yu MK; Toyota Technological Institute at Chicago, Chicago, IL 60637, USA., Mimee M; Committee on Microbiology, University of Chicago, Chicago, IL 60637, USA; Department of Microbiology, University of Chicago, Chicago, IL 60637, USA; Pritzker School of Molecular Engineering, The University of Chicago, Chicago, IL 60637, USA., Chang EB; Department of Medicine, University of Chicago, Chicago, IL 60637, USA., Ruscheweyh HJ; Department of Biology, Institute of Microbiology and Swiss Institute of Bioinformatics, ETH Zurich, Zurich 8093, Switzerland., Sunagawa S; Department of Biology, Institute of Microbiology and Swiss Institute of Bioinformatics, ETH Zurich, Zurich 8093, Switzerland., Mclellan SL; School of Freshwater Sciences, University of Wisconsin-Milwaukee, Milwaukee, WI 53204, USA., Willis AD; Department of Biostatistics, University of Washington, Seattle, WA 98195, USA., Comstock LE; Committee on Microbiology, University of Chicago, Chicago, IL 60637, USA; Duchossois Family Institute, University of Chicago, Chicago, IL 60637, USA; Department of Microbiology, University of Chicago, Chicago, IL 60637, USA. Electronic address: lecomstock@bsd.uchicago.edu., Eren AM; Department of Medicine, University of Chicago, Chicago, IL 60637, USA; Marine Biological Laboratory, Woods Hole, MA 02543, USA; Alfred Wegener Institute Helmholtz Centre for Polar and Marine Research, 27570 Bremerhaven, Germany; Institute for Chemistry and Biology of the Marine Environment, University of Oldenburg, 26129 Oldenburg, Germany; Max Planck Institute for Marine Microbiology, 28359 Bremen, Germany; Helmholtz Institute for Functional Marine Biodiversity, 26129 Oldenburg, Germany. Electronic address: meren@hifmb.de.

Publikováno v: Cell [Cell] 2024 Feb 29; Vol. 187 (5), pp. 1206-1222.e16.

A highly conserved and globally prevalent cryptic plasmid is among the most numerous mobile genetic elements in the human gut.

Autor: Fogarty EC; Committee on Microbiology, University of Chicago, Chicago, IL 60637, USA.; Duchossois Family Institute, University of Chicago, Chicago, IL 60637, USA.; Department of Medicine, University of Chicago, Chicago, IL 60637, USA., Schechter MS; Committee on Microbiology, University of Chicago, Chicago, IL 60637, USA.; Duchossois Family Institute, University of Chicago, Chicago, IL 60637, USA.; Department of Medicine, University of Chicago, Chicago, IL 60637, USA., Lolans K; Department of Medicine, University of Chicago, Chicago, IL 60637, USA., Sheahan ML; Duchossois Family Institute, University of Chicago, Chicago, IL 60637, USA.; Department of Microbiology, University of Chicago, Chicago, IL, 60637, USA., Veseli I; Department of Medicine, University of Chicago, Chicago, IL 60637, USA.; Graduate Program in Biophysical Sciences, University of Chicago, Chicago, IL 60637, USA., Moore R; Center for Bioinformatics and Computational Biology, University of Delaware, Newark, DE, USA., Kiefl E; Department of Medicine, University of Chicago, Chicago, IL 60637, USA.; Graduate Program in Biophysical Sciences, University of Chicago, Chicago, IL 60637, USA., Moody T; Department of Systems Biology, Columbia University, New York, NY, 10032 USA., Rice PA; Committee on Microbiology, University of Chicago, Chicago, IL 60637, USA.; Department of Biochemistry, University of Chicago, Chicago, IL, 60637, USA., Yu MK; Toyota Technological Institute at Chicago., Mimee M; Committee on Microbiology, University of Chicago, Chicago, IL 60637, USA.; Department of Microbiology, University of Chicago, Chicago, IL, 60637, USA.; Pritzker School of Molecular Engineering, The University of Chicago, Chicago, IL 60637, USA., Chang EB; Department of Medicine, University of Chicago, Chicago, IL 60637, USA., Mclellan SL; School of Freshwater Sciences, University of Wisconsin-Milwaukee, Milwaukee, WI, 53204, USA., Willis AD; Department of Biostatistics, University of Washington, Seattle, WA, 98195, USA., Comstock LE; Duchossois Family Institute, University of Chicago, Chicago, IL 60637, USA.; Department of Microbiology, University of Chicago, Chicago, IL, 60637, USA., Eren AM; Marine Biological Laboratory, Woods Hole, MA, 02543, USA.; Alfred Wegener Institute, Helmholtz Centre for Polar and Marine Research, 27570 Bremerhaven, Germany.; Institute for Chemistry and Biology of the Marine Environment, University of Oldenburg, 26129 Oldenburg, Germany.; Helmholtz Institute for Functional Marine Biodiversity, 26129 Oldenburg, Germany.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Mar 25. Date of Electronic Publication: 2023 Mar 25.