Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Shea Jj, O."'
2
Importance of the MKK6/p38 pathway for interleukin-12-induced STAT4 serine phosphorylation and transcriptional activity
Autor: Visconti R, Gadina M, Chiariello M, Eh, Chen, Lf, Stancato, J Silvio Gutkind, Shea Jj, O.
Publikováno v: Blood 96 (2000): 1844–1852.
info:cnr-pdr/source/autori:Visconti R; Gadina M; Chiariello M; Chen EH; Stancato LF; Gutkind JS; O'Shea JJ/titolo:Importance of the MKK6%2Fp38 pathway for interleukin-12-induced STAT4 serine phosphorylation and transcriptional activity/doi:/rivista:Blood/anno:2000/pagina_da:1844/pagina_a:1852/intervallo_pagine:1844–1852/volume:96
Europe PubMed Central
Interleukin-12 (IL-12) is a key immunoregulatory cytokine that promotes Th1 differentiation and cell-mediated immune responses. The transcription factor STAT4 (signal transducer and activator of transcription 4) is an important element in mediating I
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::5c070d4c1431a40ae0ffea50e7d2102a
http://www.cnr.it/prodotto/i/190483
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3
Induction of T cell differentiation and lymphomagenesis in the thymus of mice with severe combined immune deficiency (SCID)
Autor: Wj, Murphy, scott durum, Anver MR, Dk, Ferris, Dw, Mcvicar, Shea Jj, O., Sk, Ruscetti, Smith MR, Ha, Young, Dl, Longo
Publikováno v: Europe PubMed Central
Severe combined immune deficiency (SCID) mice have a defect in their recombinase system and cannot productively rearrange their immune receptor genes. Thus, SCID thymocytes are arrested at the immature "triple negative" phase, not expressing CD3, CD4
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a5fc47bacf8600b82cb5a416a4d2aebb
http://europepmc.org/abstract/med/7913108
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4
Regulation of JAK3 expression and activation in human B cells and B cell malignancies
Autor: Pj, Tortolani, Bk, Lal, Riva A, Ja, Johnston, Yq, Chen, Gh, Reaman, Beckwith M, Longo D, Jr, Ortaldo, Bhatia K, McGrath I, Kehrl J, Tuscano J, Daniel McVicar, Shea Jj, O.
Publikováno v: Europe PubMed Central
Members of the Janus family (JAK) of protein tyrosine kinases are critical enzymes in signaling pathways via hematopoietin receptors. We have cloned JAK3, which unlike other known family members (JAK1, JAK2, and TYK2) is preferentially expressed in h
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a7bef567635d3542d74af278680def90
http://europepmc.org/abstract/med/7594533
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5
IL-12 induces IFN regulating factor-1 (IRF-1) gene expression in human NK and T cells
Autor: Jérôme Galon, Sudarshan C, Ito S, Finbloom D, Shea Jj, O.
Publikováno v: Europe PubMed Central
IL-12 is a critical immunoregulatory cytokine that promotes cell-mediated immune responses and the differentiation of naive CD4+ cells to Th1 cells; however, relatively few IL-12 target genes have been identified. To better clarify the molecular basi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0274ed207539b2d94e57aab195bc97c6
http://europepmc.org/abstract/med/10358173
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6
Structural and functional basis for JAK3-deficient severe combined immunodeficiency
Autor: Candotti F, Sa, Oakes, Ja, Johnston, Giliani S, Rf, Schumacher, Mella P, Fiorini M, Ag, Ugazio, Badolato R, Ld, Notarangelo, Fabio Bozzi, Macchi P, Strina D, Vezzoni P, Rm, Blaese, Shea Jj, O., Villa A
Publikováno v: Europe PubMed Central
Mutations of the Janus family kinase JAK3 have been found to be responsible for autosomal recessive severe combined immunodeficiency (SCID) in humans. We report here the analysis of four new unrelated patients affected by JAK3-deficient SCID. The gen
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f1c0ab852281738f6a13205f2938ea91
http://europepmc.org/abstract/med/9354668
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7
Thrombopoietin induces tyrosine phosphorylation and activation of the Janus kinase, JAK2
Autor: Pj, Tortolani, Ja, Johnston, Cm, Bacon, Daniel McVicar, Shimosaka A, Linnekin D, Dl, Longo, Shea Jj, O.
Publikováno v: Europe PubMed Central
Thrombopoietin (TPO) is a recently characterized growth and differentiation factor for megakaryocytes and platelets that exerts its effects via the receptor, c-MpI. This receptor is a member of the hematopoietin receptor superfamily and is essential
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::82050c7dff914fc2a791b42affa5fd62
http://europepmc.org/abstract/med/7780132
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8
Involvement of SHP-2 in multiple aspects of IL-2 signaling: evidence for a positive regulatory role
Autor: Gadina M, Lm, Stancato, Chris Bacon, Ac, Larner, Shea Jj, O.
Publikováno v: Europe PubMed Central
Binding of IL-2 to its receptor activates several biochemical pathways, but precisely how these pathways are linked is incompletely understood. Here, we report that SHP-2, an SH2-domain containing tyrosine phosphatase, associates with different molec
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::08f9920de29e1c0847eb47ffa2b5103f
http://europepmc.org/abstract/med/9590209
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9
Molecular cloning of lsk, a carboxyl-terminal src kinase (csk) related gene, expressed in leukocytes
Autor: Daniel McVicar, Bk, Lal, Lloyd A, Kawamura M, Yq, Chen, Zhang X, Je, Staples, Jr, Ortaldo, Shea Jj, O.
Publikováno v: Europe PubMed Central
Regulation of the activity of src-family kinases is thought to occur, in part, through the phosphorylation of conserved carboxyl-terminal tyrosine residues. Although the src-family includes several molecules with tissue or cell-type restricted expres
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::17eeb30ba0564adf4d01623ec3226085
http://europepmc.org/abstract/med/7516063
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