Výsledky vyhledávání - "Shea Fern Lim"

Increasing Linker Chain Length and Intestinal Stability Enhances Lymphatic Transport and Lymph Node Exposure of Triglyceride Mimetic Prodrugs of a Model Immunomodulator Mycophenolic Acid

Autor: Sifei Han, Tim Quach, Luojuan Hu, Shea Fern Lim, Dan Zheng, Nathania J. Leong, Garima Sharma, Daniel Bonner, Jamie S. Simpson, Natalie L. Trevaskis, Christopher J.H. Porter

Publikováno v: Molecular Pharmaceutics. 20:2675-2685

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::06c742e85019a0b346d5ed0b17b54e0a
https://doi.org/10.1021/acs.molpharmaceut.3c00099

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The Impact of Conjugation Position and Linker Chemistry on the Lymphatic Transport of a Series of Glyceride and Phospholipid Mimetic Prodrugs

Autor: Jamie S. Simpson, Tim Quach, Christopher J.H. Porter, Gracia Gracia, Natalie L. Trevaskis, Shea Fern Lim, Luojuan Hu, Sifei Han

Publikováno v: Journal of Pharmaceutical Sciences. 110:489-499

Drug delivery to the lymphatic system is gaining increasing attention, particularly in fields such as immunotherapy where drug access to lymphocytes is central to activity. We have previously described a prodrug strategy that facilitates the lymphati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6b43b721e3deedcfa8b1d97b15c3478
https://doi.org/10.1016/j.xphs.2020.10.021

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Reactions of Thiiranium and Sulfonium Ions with Alkenes in the Gas Phase

Autor: Samuel C. Brydon, Shea Fern Lim, Jonathan M. White, Richard A. J. O'Hair, Philippe Maître, George N. Khairallah, Estelle Loire, Gabriel da Silva

Publikováno v: Journal of Organic Chemistry
Journal of Organic Chemistry, American Chemical Society, 2019, 84 (16), pp.10076-10087. ⟨10.1021/acs.joc.9b01264⟩

Ion–molecule reactions between thiiranium ion 11 (m/z 213) and cyclohexene and cis-cyclooctene resulted in the formation of addition products 17a and 17b (m/z 295 and m/z 323, respectively) via an ...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c90f0433bbd7ad7a8da293323d2f80f
https://pubmed.ncbi.nlm.nih.gov/31328517

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Enhancing the Oral Absorption of Kinase Inhibitors Using Lipophilic Salts and Lipid-Based Formulations

Autor: Leigh Ford, David M. Shackleford, Colin W. Pouton, Hassan Benameur, David T. Vodak, Sifei Han, Christopher J.H. Porter, Kristian J. Tangso, Hywel David Williams, Peter J. Scammells, Shea Fern Lim

Publikováno v: Molecular pharmaceutics. 15(12)

The absolute bioavailability of many small molecule kinase inhibitors (smKIs) is low. The reasons for low bioavailability are multifaceted and include constraints due to first pass metabolism and poor absorption. For smKIs where absorption limits ora

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56c08bef060563ffba6c8141420ce45f
https://pubmed.ncbi.nlm.nih.gov/30376336

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Transformation of Biopharmaceutical Classification System Class I and III Drugs Into Ionic Liquids and Lipophilic Salts for Enhanced Developability Using Lipid Formulations

Autor: John M. Baumann, Shea Fern Lim, Hywel David Williams, Annabel Igonin, Leigh Ford, Colin W. Pouton, Hannah Sullivan, Christopher J.H. Porter, Sifei Han, Hassan Benameur, David T. Vodak, Peter J. Scammells

Publikováno v: Journal of pharmaceutical sciences. 107(1)

Higher lipid solubility of lipophilic salt forms creates new product development opportunities for high-dose liquid-filled capsules. The purpose of this study is to determine if lipophilic salts of Biopharmaceutical Classification System (BCS) Class

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e28015b35d0b3901bb6121753be3524c
https://pubmed.ncbi.nlm.nih.gov/28549907

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Glyceride-Mimetic Prodrugs Incorporating Self-Immolative Spacers Promote Lymphatic Transport, Avoid First-Pass Metabolism, and Enhance Oral Bioavailability

Autor: Danielle Senyschyn, Christopher J.H. Porter, Natalie L. Trevaskis, Tim Quach, Jamie S. Simpson, Shea Fern Lim, Luojuan Hu, Preeti Yadav, Sifei Han

Publikováno v: Angewandte Chemie (International ed. in English). 55(44)

First-pass hepatic metabolism can significantly limit oral drug bioavailability. Drug transport from the intestine through the lymphatic system, rather than the portal vein, circumvents first-pass metabolism. However, the majority of drugs do not hav

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbeb32d91ae07eed800e16ba414d7420
https://pubmed.ncbi.nlm.nih.gov/27482655

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