Zobrazeno 1 - 10
of 53
pro vyhledávání: '"She-Hung Chan"'
Publikováno v:
Current Issues in Molecular Biology, Vol 44, Iss 11, Pp 5550-5561 (2022)
Adenomyosis is a uterine pathology characterized by a deep invasion of endometrial glands and stroma, disrupting the endometrial–myometrial interface (EMI). Interleukin-18 (IL-18) system is a dominant cytokine involved in the menstrual cycle of hum
Externí odkaz:
https://doaj.org/article/186d5e3d59d74ca9a8007dc595230ad6
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 20, p 11239 (2021)
Acute myeloid leukemia (AML) is one of the most common forms of leukemia. Despite advances in the management of such malignancies and the progress of novel therapies, unmet medical needs still exist in AML because of several factors, including poor r
Externí odkaz:
https://doaj.org/article/4d86401008fa472d9d96c68440780ae4
Autor:
Jo-Fan Chang, Jui-Ling Hsu, Yi-Hua Sheng, Wohn-Jenn Leu, Chia-Chun Yu, She-Hung Chan, Mei-Ling Chan, Lih-Ching Hsu, Shih-Ping Liu, Jih-Hwa Guh
Publikováno v:
Frontiers in Oncology, Vol 8 (2019)
Human castration-resistant prostate cancer (CRPC) is a significant target of clinical research. The use of DNA-damaging agents has a long history in cancer chemotherapy but is limited by their toxicities. The combination with a safer drug can be a st
Externí odkaz:
https://doaj.org/article/3a701bd102534e719249fe95c6948b24
Autor:
She-Hung Chan, Wohn-Jenn Leu, Sharada Prasanna Swain, Jui-Ling Hsu, Duen-Ren Hou, Jih-Hwa Guh
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 7, p 2470 (2020)
Various derivatives that mimic ceramide structures by introducing a triazole to connect the aminodiol moiety and long alkyl chain have been synthesized and screened for their anti-leukemia activity. SPS8 stood out among the derivatives, showing cytot
Externí odkaz:
https://doaj.org/article/f6009da4ffc449f5b2b029e7af7d9211
Autor:
Wohn-Jenn Leu, Hsun-Shuo Chang, She-Hung Chan, Jui-Ling Hsu, Chia-Chun Yu, Lih-Ching Hsu, Ih-Sheng Chen, Jih-Hwa Guh
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e87323 (2014)
In the past decade, there has been a profound increase in the number of studies revealing that cardenolide glycosides display inhibitory activity on the growth of human cancer cells. The use of potential cardenolide glycosides may be a worthwhile app
Externí odkaz:
https://doaj.org/article/48bc6de0cab044a5b752cb618d06a070
Autor:
Wohn-Jenn Leu, Konstantin V. Kudryavtsev, Jih-Hwa Guh, Özdemir Dogan, Mei-Ling Chan, Chia-Chun Yu, She-Hung Chan, Lih-Ching Hsu, Polina M. Ivantcova, Stefan Bräse, Shih-Ping Liu, Jui-Ling Hsu
Publikováno v:
Oncotarget
OncoTarget, 8 (57), 96668-96683
OncoTarget, 8 (57), 96668-96683
// Mei-Ling Chan 1 , Chia-Chun Yu 1 , Jui-Ling Hsu 1 , Wohn-Jenn Leu 1 , She-Hung Chan 1 , Lih-Ching Hsu 1 , Shih-Ping Liu 2, 3 , Polina M. Ivantcova 4 , Ozdemir Dogan 5 , Stefan Brase 6, 7 , Konstantin V. Kudryavtsev 4, 8 and Jih-Hwa Guh 1 1 School
Autor:
Hsaio Lin Hwa, Pin Chieh Chi, Da Peng Yang, Chien Ming Hsieh, Cheng-Chung Fang, Ju Yu Chen, Huei-Wen Chen, She Hung Chan, Kai Wen Cheng, Pai Shan Chen, Te-I Weng
Publikováno v:
Rapid Communications in Mass Spectrometry. 34
Rationale The presence of α-pyrrolidinovalerophenone (α-PVP) and its metabolites in urine is evidence of the administration of α-PVP. A toxicological challenge is that the metabolites of α-PVP exhibit amphoteric properties, which make them unsuit
Autor:
She Hung Chan, Yves S.Y. Hsieh, Yu Pu Juang, Jiun-Jie Shie, Pi-Hui Liang, Jih-Hwa Guh, You Yu Lin, Chun Kai Chang
Publikováno v:
Bioorganic chemistry. 99
A series ofN-acyl glucosamine-bearingtriterpenoidsaponins has been synthesized with cytotoxic activities evaluated against HL-60, PC-3, HCT-116, and CT-26 tumor cells. Saponins incorporated anoleanolic acid (OA) triterpenoidal core exhibited the high
Publikováno v:
European Journal of Medicinal Chemistry. 143:1942-1958
A series of N-acyl, N-alkoxycarbonyl, and N-alkylcarbamoyl derivatives of 2′-deoxy-glucosyl bearing oleanolic saponins were synthesized and evaluated against HL-60, PC-3, and HT29 tumor cancer cells. The SAR studies revealed that the activity incre
Autor:
Shih-Ping Liu, Lih-Ching Hsu, Duen Ren Hou, Wohn Jenn Leu, Yen Lin Chou, Mei Ling Chan, Jih-Hwa Guh, Jui-Ling Hsu, Wei-Ling Chang, Chia Chun Yu, Sharada Prasanna Swain, She Hung Chan
Publikováno v:
Oncotarget
// Wohn-Jenn Leu 1, * , Sharada Prasanna Swain 2, * , She-Hung Chan 1 , Jui-Ling Hsu 1 , Shih-Ping Liu 3 , Mei-Ling Chan 1 , Chia-Chun Yu 1 , Lih-Ching Hsu 1 , Yen-Lin Chou 2 , Wei-Ling Chang 1 , Duen-Ren Hou 2 , Jih-Hwa Guh 1 1 School of Pharmacy, N