Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Shayne N. Hassler"'
Autor:
Bianca N. Mason, Shayne N. Hassler, Kathryn DeFea, Scott Boitano, Josef Vagner, Theodore J. Price, Greg Dussor
Publikováno v:
The Journal of Headache and Pain, Vol 24, Iss 1, Pp 1-12 (2023)
Abstract Background Migraine is a severely debilitating disorder that affects millions of people worldwide. Studies have indicated that activation of protease-activated receptor-2 (PAR2) in the dura mater causes headache responses in preclinical mode
Externí odkaz:
https://doaj.org/article/e59629c7f6954a7284df0a868cea63a5
Autor:
Benjamin D. Rivera, Nakleh Mseeh, Moeno Kume, Ayesha Ahmad, Breya P. Ludwig, Josef Vagner, Changyu Jiang, Marvin T. Nieman, Ru-Rong Ji, Scott Boitano, Gregory Dussor, Pradipta R. Ray, Shayne N. Hassler, Thomas Van de Ven, Alexander Chamessian, Juliet Mwirigi, Theodore J. Price
Publikováno v:
J Pain
The protease activated receptor (PAR) family is a group of G-protein coupled receptors (GPCRs) activated by proteolytic cleavage of the extracellular domain. PARs are expressed in a variety of cell types with crucial roles in homeostasis, immune resp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb5f29a66d4459199b03dec06c750b7a
https://europepmc.org/articles/PMC8197731/
https://europepmc.org/articles/PMC8197731/
Autor:
Shayne N, Hassler, Moeno, Kume, Juliet M, Mwirigi, Ayesha, Ahmad, Stephanie, Shiers, Andi, Wangzhou, Pradipta R, Ray, Serge N, Belugin, Dhananjay K, Naik, Michael D, Burton, Josef, Vagner, Scott, Boitano, Armen N, Akopian, Gregory, Dussor, Theodore J, Price
Publikováno v:
JCI Insight
Protease-activated receptor 2 (PAR2) has long been implicated in inflammatory and visceral pain, but the cellular basis of PAR2-evoked pain has not been delineated. Although PAR2-evoked pain has been attributed to sensory neuron expression, RNA-seque
The cellular basis of protease activated receptor type 2 (PAR2) evoked mechanical and affective pain
Autor:
Serge N. Belugin, Armen N. Akopian, Andi Wangzhou, Pradipta R. Ray, Juliet Mwirigi, Michael D. Burton, Moeno Kume, Theodore J. Price, Josef Vagner, Ayesha Ahmad, Stephanie Shiers, Shayne N. Hassler, Gregory Dussor, Dhananjay K. Naik, Scott Boitano
Protease-activated receptor type-2 (PAR2) has long been implicated in inflammatory and visceral pain, but the cellular basis of PAR2-evoked pain has not been delineated. While many studies have attributed PAR2-evoked pain to sensory neuron expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc85f2e60b917e73803e356f16a88fd2
https://doi.org/10.1101/2020.01.31.928663
https://doi.org/10.1101/2020.01.31.928663
Autor:
Scott Boitano, Gregory Dussor, Shayne N. Hassler, Carolina C. Burgos-Vega, Josef Vagner, Theodore J. Price, Fatima B Ahmad
Publikováno v:
Cephalalgia : an international journal of headache. 39(1)
Background Pain is the most debilitating symptom of migraine. The cause of migraine pain likely requires activation of meningeal nociceptors. Mast cell degranulation, with subsequent meningeal nociceptor activation, has been implicated in migraine pa
Autor:
Theodore J. Price, Halley R. Washburn, Guoan Zhang, Sean I. Sheffler-Collins, Nan L. Xia, Thomas A. Neubert, Dipti V. Tillu, Kenji Hanamura, Matthew B. Dalva, Nathan T Henderson, Daniel S. Spellman, Shayne N. Hassler
Publikováno v:
PLoS Biology
PLoS Biology, Vol 15, Iss 7, p e2002457 (2017)
PLoS Biology, Vol 15, Iss 7, p e2002457 (2017)
Extracellular phosphorylation of proteins was suggested in the late 1800s when it was demonstrated that casein contains phosphate. More recently, extracellular kinases that phosphorylate extracellular serine, threonine, and tyrosine residues of numer
Publikováno v:
Journal of Neurochemistry. 131:413-417
Chronic neuropathic pain is a common consequence of spinal cord injury (SCI), develops over time and negatively impacts quality of life, often leading to substance abuse and suicide. Recent evidence has demonstrated that reactive oxygen species (ROS)
Autor:
Shayne N. Hassler, Carolina C. Burgos-Vega, Theodore J. Price, Gregory Dussor, Tammie Quinn, Robert E. Sorge, Dipti V. Tillu, Scott Boitano, Josef Vagner
Publikováno v:
Pain. 156(5)
Protease-activated receptor type 2 (PAR2) is known to play an important role in inflammatory, visceral, and cancer-evoked pain based on studies using PAR2 knockout (PAR2(-/-)) mice. We have tested the hypothesis that specific activation of PAR2 is su
Publikováno v:
The Journal of Pain. 18:S11
(292) Protease activated receptor 2 (PAR2) is a mediator of nociception in a mouse model of migraine
Publikováno v:
The Journal of Pain. 17:S49