Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Shayne D. Hastings"'
Publikováno v:
Frontiers in Systems Neuroscience, Vol 17 (2023)
There is a growing appreciation for the cerebellum beyond its role in motor function and accumulating evidence that the cerebellum and hippocampus interact across a range of brain states and behaviors. Acute and chronic manipulations, simultaneous re
Externí odkaz:
https://doaj.org/article/b6da171d9d554ec1af1b5fdfa8338e31
Publikováno v:
Hippocampus
M-type (KCNQ2/3) K(+) channels play dominant roles in regulation of active and passive neuronal discharge properties such as resting membrane potential, spike-frequency adaptation, and hyper-excitatory states. However, plasticity of M-channel express
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fc0d7439f186d1218948d75731e5668
https://doi.org/10.1002/hipo.23163
https://doi.org/10.1002/hipo.23163
Publikováno v:
J Nat Prod
The C-22,23-epoxy taccalonolides are microtubule stabilizers that bind covalently to β-tubulin with a high degree of specificity. We semisynthesized and performed biochemical and cellular evaluations on 20 taccalonolide analogues designed to improve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1f43008ffe0e746c29cfc00adf71b7b
https://europepmc.org/articles/PMC8656239/
https://europepmc.org/articles/PMC8656239/
Autor:
Shayne D. Hastings, Rafael J. Veraza, Deborah M. Holstein, Isamar Sanchez, Sang H Chun, Mark S. Shapiro, MaryAnn Hobbs, Robert Brenner, José E Cavazos, Shane Sprague, Chase M. Carver, Fabio A. Vigil, Eda Bozdemir, Vladislav Bugay, James D. Lechleiter
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 40:1256-1273
Nearly three million people in the USA suffer traumatic brain injury (TBI) yearly; however, there are no pre- or post-TBI treatment options available. KCNQ2-5 voltage-gated K+ channels underlie the neuronal “M current”, which plays a dominant rol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d470768f417518b0239f08f0545b7b0
https://doi.org/10.1177/0271678x19857818
https://doi.org/10.1177/0271678x19857818
Autor:
Susan L. Mooberry, Shayne D. Hastings, Madesh Muniswamy, Corena V Grant, Chase M. Carver, April L. Risinger, John A. Beutler, Karthik Ramachandran
Publikováno v:
Breast Cancer Res Treat
PURPOSE: Triple-negative breast cancers (TNBCs) represent a heterogeneous group of tumors. The lack of targeted therapies combined with the inherently aggressive nature of TNBCs results in a higher relapse rate and poorer overall survival. We evaluat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f98003ebb0dbb6c3bbf2bc39dd9969f
https://doi.org/10.1007/s10549-019-05324-7
https://doi.org/10.1007/s10549-019-05324-7
Autor:
Griffin B. Foultz, Shayne D. Hastings, Doug E. Frantz, Hadi D. Arman, Nicholas A Clanton, Julie A. Contreras, April L. Risinger, Samantha S. Yee
Publikováno v:
ACS Med Chem Lett
[Image: see text] Natural products have served as inspirational scaffolds for the design and synthesis of novel antineoplastic agents. Here we present our preliminary efforts on the synthesis and biological evaluation of a new class of electrophilic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d093b2792f8dd273224bc7f16915b7cf
https://pubmed.ncbi.nlm.nih.gov/33335677
https://pubmed.ncbi.nlm.nih.gov/33335677
Publikováno v:
Cancer Research. 80:P5-05
Immune checkpoint inhibitors targeting the PD1/PD-L1 and CTLA4 signaling axes have made a significant impact in the treatment of some solid tumors, particularly melanoma and non-small-cell lung carcinoma. While triple-negative breast cancers (TNBC) t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3cd747e2a3b73ee49be21e650d59fd93
https://doi.org/10.1158/1538-7445.sabcs19-p5-05-03
https://doi.org/10.1158/1538-7445.sabcs19-p5-05-03
Autor:
John A. Beutler, April L. Risinger, Chase M. Carver, Susan L. Mooberry, Corena V Grant, Shayne D. Hastings
Publikováno v:
Cancer Research. 79:2143-2143
Identification of new molecular liabilities of a subset of triple-negative breast cancers through the investigation of englerin A There remains a need to identify targeted therapies for triple-negative breast cancers (TNBCs) but a major challenge has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1271aa7b1a0f7d94529c92da49947b06
https://doi.org/10.1158/1538-7445.am2019-2143
https://doi.org/10.1158/1538-7445.am2019-2143
Publikováno v:
Biophysical Journal. 116:397a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::801ffff505fc9b94f1e0be255fb77389
https://doi.org/10.1016/j.bpj.2018.11.2144
https://doi.org/10.1016/j.bpj.2018.11.2144