Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Shayne A. Bellingham"'
Autor:
Lesley Cheng, Camelia Quek, Xia Li, Shayne A. Bellingham, Laura J. Ellett, Mitch Shambrook, Saima Zafar, Inga Zerr, Victoria A. Lawson, Andrew F. Hill
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Cheng et al. present differentially expressed extracellular vesicle miRNAs in human clinical samples from patients who suffer from sporadic Creutzfeldt-Jakob disease. This study identifies biomarkers that can be used to detect prion-related diseases,
Externí odkaz:
https://doaj.org/article/39c8cfc317f54c2eb8c47b3a23e018f6
Publikováno v:
Journal of Extracellular Vesicles, Vol 4, Iss 0, Pp 1-10 (2015)
Small non-coding RNAs have been significantly recognized as the key modulators in many biological processes, and are emerging as promising biomarkers for several diseases. These RNA species are transcribed in cells and can be packaged in extracellula
Externí odkaz:
https://doaj.org/article/c866859169e241ff801eacecd831c994
Autor:
Claudia Santosa, Stefanie Rasche, Adel Barakat, Shayne A. Bellingham, Michael Ho, Jiangli Tan, Andrew F. Hill, Colin L. Masters, Catriona McLean, Geneviève Evin
Publikováno v:
Neurobiology of Disease, Vol 43, Iss 1, Pp 176-183 (2011)
BACE initiates the amyloidogenic processing of the amyloid precursor protein (APP) that results in the production of Aβ peptides associated with Alzheimer's disease (AD). Previous studies have indicated that BACE is elevated in the frontal cortex of
Externí odkaz:
https://doaj.org/article/e88bd75093f2400b817d0a4e5cc468ec
Autor:
Greg Pratt, Bastien Llamas, Ruth M. Arkell, Shayne A. Bellingham, Cliff J Meldrum, Ravi Savarirayan, Lynette Russell, Alex Brown, Saul Newman, Carola G. Vinuesa, Hugh Dawkins, Shivashankar H. Nagaraj, Warren Kaplan, John Skinner, Ashley Farlow, Wendy E. Hoy, Simon Easteal, Hardip R. Patel, Graham J. Mann, Tom Calma, Kylie Gwynne, Misty R. Jenkins, Lyndon Ormond-Parker, Marcel E. Dinger, Jack Nunn, Rebekah McWhirter, Boe Rambaldini, Matthew Silcocks, Gareth Baynam, Matthew C. Cook, Michael S. Dobbie, Devashi Paliwal, Simon H Jiang, Stephen Leslie, Brendan J. McMorran, Neil Orr, Azure Hermes, Megan Davis, Yassine Souilmi, Renzo F. Balboa, Glenn Pearson
Publikováno v:
Am J Hum Genet
Expanded carrier screening (ECS) for recessive monogenic diseases requires prior knowledge of genomic variation, including DNA variants that cause disease. The composition of pathogenic variants differs greatly among human populations, but historical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b38fea929d04463f457071370eee539
https://doi.org/10.1016/j.ajhg.2020.06.005
https://doi.org/10.1016/j.ajhg.2020.06.005
Exosomes are small extracellular vesicles released by cells and play important roles in intercellular communication and pathogen transfer. Exosomes have been implicated in several neurodegenerative diseases, including prion disease and Alzheimer dise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60a4ff48d633d4fffd4d76e230b84e33
Autor:
Lesley Cheng, Andrew F. Hill, Shayne A. Bellingham, Robyn A. Sharples, Benjamin J. Scicluna, Mitch Shambrook, Chol-Hee Jung, Camelia Quek
Publikováno v:
RNA Biology
Small non-coding RNAs (ncRNA), including microRNAs (miRNA), enclosed in exosomes are being utilised for biomarker discovery in disease. Two common exosome isolation methods involve differential ultracentrifugation or differential ultracentrifugation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0201daa45f7961001eaaeba7f83268e1
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-17 (2019)
Scientific Reports
Scientific Reports
MicroRNAs (miRNAs) are a class of small non-coding RNAs that regulate gene or protein expression by targeting mRNAs and triggering either translational repression or mRNA degradation. Distinct expression levels of miRNAs, including miR-29b, have been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb0824071873641fadb42e7ed087b5ef
http://link.springer.com/article/10.1038/s41598-019-53868-x
http://link.springer.com/article/10.1038/s41598-019-53868-x
Publikováno v:
Frontiers in Genetics, Vol 4 (2013)
Diagnostic tools for neurodegenerative diseases such as Alzheimer's disease (AD) currently involve subjective neuropsychological testing and specialised brain imaging techniques. While definitive diagnosis requires a pathological brain evaluation at
Externí odkaz:
https://doaj.org/article/75ae7516aef14e589f52776d123381b4
Autor:
Mitch Shambrook, Laura J Ellett, Xia Li, Saima Zafar, Lesley Cheng, Andrew F. Hill, Inga Zerr, Shayne A. Bellingham, Camelia Quek, Victoria A. Lawson
Publikováno v:
Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Communications biology 4(1), 411 (2021). doi:10.1038/s42003-021-01868-x
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Communications biology 4(1), 411 (2021). doi:10.1038/s42003-021-01868-x
Prion diseases are distinguished by long pre-clinical incubation periods during which prions actively propagate in the brain and cause neurodegeneration. In the pre-clinical stage, we hypothesize that upon prion infection, transcriptional changes occ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::965ec9c52039203d11f1dcba9bcf08a5
https://pubmed.ncbi.nlm.nih.gov/33767334
https://pubmed.ncbi.nlm.nih.gov/33767334
Publikováno v:
Frontiers in Physiology, Vol 3 (2012)
Exosomes are small membranous vesicles secreted by a number of cell types including neurons and can be isolated from conditioned cell media or bodily fluids such as urine and plasma. Exosome biogenesis involves the inward budding of endosomes to form
Externí odkaz:
https://doaj.org/article/502e2b2be13f4a38aa660531c7ed2c3d