Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Shayna Levine"'
Autor:
Arpita Kulshrestha, Gajendra K. Katara, Safaa A. Ibrahim, Valerie E. Riehl, Sylvia Schneiderman, Mahmood Bilal, Alexandria N. Young, Shayna Levine, Sara Fleetwood, James Dolan, Alice Gilman‐Sachs, Kenneth D. Beaman
Publikováno v:
Molecular Oncology, Vol 14, Iss 10, Pp 2436-2454 (2020)
Tumor acidity is the key metabolic feature promoting cancer progression and is modulated by pH regulators on a cancer cell's surface that pump out excess protons/lactic acid for cancer cell survival. Neutralizing tumor acidity improves the therapeuti
Externí odkaz:
https://doaj.org/article/a303e506c5224df1b905decf62dbe935
Autor:
Valerie Riehl, Sylvia Schneiderman, Shayna Levine, Alexandria N. Young, Safaa A. Ibrahim, James Dolan, Arpita Kulshrestha, Mahmood Bilal, Kenneth D. Beaman, Sara Fleetwood, Gajendra K. Katara, Alice Gilman-Sachs
Publikováno v:
Molecular Oncology
Molecular Oncology, Vol 14, Iss 10, Pp 2436-2454 (2020)
Molecular Oncology, Vol 14, Iss 10, Pp 2436-2454 (2020)
Tumor acidity is the key metabolic feature promoting cancer progression by eliciting immune‐suppression. V‐ATPases on a cancer cell's surface pump out excess protons and acidify the tumor microenvironment (TME). In vivo treatment of ovarian tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0923bfdecac6564a54c9ceac6bba8ae
https://doi.org/10.1002/1878-0261.12782
https://doi.org/10.1002/1878-0261.12782
Abstract B64: Targeting the pH regulators in the tumor microenvironment for ovarian cancer treatment
Autor:
Alexandria N. Young, Sylvia Schneiderman, Safaa A. Ibrahim, Gajendra K. Katara, Arpita Kulshrestha, Shayna Levine, Valerie Riehl, Alice Gilman-Sachs, Mahmood Bilal, Kenneth D. Beaman
Publikováno v:
Clinical Cancer Research. 26:B64-B64
The high mortality rate in ovarian cancer (OVCA) is currently the most pressing concern despite the research advancements. It is still not clear how to effectively treat OVCA patients to prevent a relapse or to treat the relapse tumors that display a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce29fe6f193dfdc730a5c1988a5c068f
https://doi.org/10.1158/1557-3265.ovca19-b64
https://doi.org/10.1158/1557-3265.ovca19-b64
Autor:
Kenneth D. Beaman, Gajendra K. Katara, Shayna Levine, Mahmood Bilal, Alexandria N. Young, Alice Gilman-Sachs, Safaa A. Ibrahim, Arpita Kulshrestha, Valerie Riehl
Publikováno v:
Cancer Research. 79:106-106
The cancer cell survival relies on the over-expression of pH regulators that pump out excess protons/lactic acid, in turn acidifying the tumor microenvironment (TME) which further promotes immune suppression and metastasis. Targeting the pH regulator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42d590c9c346782b592d208eb981b228
https://doi.org/10.1158/1538-7445.am2019-106
https://doi.org/10.1158/1538-7445.am2019-106
Autor:
Kenneth D. Beaman, Shayna Levine, Safaa A. Ibrahim, Manoranjan Sahoo, Gajendra K. Katara, Alice Gilman-Sachs, Arpita Kulshrestha
Publikováno v:
Cancer Research. 78:2913-2913
Tumor growth and metastasis involves complex crosstalk among cancer cells and immune infiltrates. The balance of pro- and antitumor infiltrating immune cells can impact the outcomes of tumor growth. Vacuolar-ATPase (V-ATPase) proton pump promotes can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2dfe4d7ad8f803a320e713b99652fc2f
https://doi.org/10.1158/1538-7445.am2018-2913
https://doi.org/10.1158/1538-7445.am2018-2913